The AGT gene, also known as angiotensinogen, is listed in the OMIM database. It is a scientific name for a gene that plays a crucial role in the renin-angiotensin system, which regulates blood pressure. Mutations in this gene can lead to various conditions, including recessive hypertension and renal dysgenesis.
Genetic testing for variations in the AGT gene can be done to determine if a person is at increased risk for these disorders. Additional information on this gene, including changes and variants, can be found in resources such as the Human Gene Mutation Database and the Catalog of Genes and Genetic Disorders. Testing for AGT gene variations can be done on various tissues, including the kidneys.
There are other genes and proteins related to the renin-angiotensin system, such as angiotensinogen and renin. These genes and proteins play important roles in regulating blood pressure and are also listed in databases like OMIM. PubMed provides articles and references on research related to AGT and other related genes.
For more information on AGT gene and related conditions, the Online Mendelian Inheritance in Man (OMIM) database is a valuable resource. It provides a comprehensive registry of genes and genetic disorders, as well as additional information on tests, resources, and other health conditions related to AGT and other genes associated with the renin-angiotensin system.
Health Conditions Related to Genetic Changes
The AGT gene, also known as angiotensinogen, is responsible for producing a protein called angiotensinogen. Genetic changes in this gene can lead to various health conditions.
One of the health conditions related to changes in the AGT gene is hypertension, also known as high blood pressure. The genetic variations in this gene can lead to an increased production of angiotensinogen, resulting in increased levels of angiotensin II, a hormone that causes blood vessels to constrict.
Major health insurance companies have faced legal trouble over their claim denial practices. In February 2018, the insurance commissioner of California announced plans to investigate Aetna’s coverage denial practices after a former medical director of the insurance company admitted that he never once looked at a patient’s medical records when deciding whether to deny claims over the three years he worked in the position, according to CNN.
Changes in the AGT gene have also been associated with renal tubular dysgenesis, a disorder affecting the development of kidneys. This condition is characterized by abnormal kidney function and can lead to other kidney diseases.
Testing for genetic changes in the AGT gene can be done through genetic testing. This can provide valuable information on the presence of genetic variations in this gene and help in the diagnosis and management of related conditions.
Resources such as the Online Mendelian Inheritance in Man (OMIM) and PubMed provide additional information on genetic variations in the AGT gene and related health conditions. The Human Gene Mutation Database (HGMD) and the Genetic Testing Registry (GTR) are also useful resources for accessing scientific articles and testing information on this gene.
| Condition | Genetic Changes |
|---|---|
| Hypertension | Increased production of angiotensinogen |
| Renal tubular dysgenesis | Abnormal development of kidneys |
Genetic testing for changes in the AGT gene can be done through tests such as DNA sequencing and genetic panels that focus on genes associated with hypertension and kidney disorders. It is important to consult with a healthcare professional and genetic counselor to understand the implications of genetic changes in this gene and their impact on overall health.
Renal tubular dysgenesis
Renal tubular dysgenesis is a disorder that affects the development of the kidneys. It is caused by mutations in the AGT gene, which provides instructions for making the angiotensinogen protein. This protein is involved in the renin-angiotensin system, which regulates blood pressure and the balance of fluids and electrolytes in the body.
Diagnosis of renal tubular dysgenesis can be confirmed through various tests, including genetic testing. The OMIM and other databases list the AGT gene as a known genetic cause of the condition, and variants in this gene can be tested for. Additionally, there may be other genes not yet listed for testing that are also associated with the disorder.
Research articles and references related to renal tubular dysgenesis can be found in scientific databases such as PubMed. The condition is often referred to by other names, including tubular dysgenesis. The Renal Genetic Disorders catalog and other resources provide additional information on the genetic basis and associated conditions of the disorder.
Renal tubular dysgenesis is a rare condition that is usually inherited in an autosomal recessive manner. It is characterized by underdeveloped or absent kidney tubules, which results in severe dysfunction of the kidneys. One of the main consequences of this disorder is the development of severe hypertension in affected individuals.
Patients with renal tubular dysgenesis can benefit from genetic counseling and other support services, as well as ongoing monitoring and management of the condition. Understanding the changes in the AGT gene and other associated genes can contribute to improved diagnosis and treatment of this disorder.
Hypertension
Hypertension, also known as high blood pressure, is a medical condition in which the blood pressure in the arteries is persistently elevated. It is one of the most common diseases affecting millions of people worldwide.
Genes play an important role in the development of hypertension. Several genes have been identified that are associated with an increased risk of developing the condition. These genes can be tested for their variants to assess the genetic predisposition of an individual.
Among the genes associated with hypertension, AGT (angiotensinogen) gene provides crucial information. AGT gene encodes a protein that is involved in the renin-angiotensin system, a hormonal pathway that regulates blood pressure. Variations in the AGT gene have been shown to be associated with increased risk of hypertension.
Testing for AGT gene variations can be performed using various genetic testing methods. The results of these tests can provide valuable scientific information for diagnosing the condition. PubMed and OMIM are two popular databases that provide references, articles, and other resources related to AGT gene and hypertension. The Human Gene Mutation Database and the Online Mendelian Inheritance in Man (OMIM) catalog also provide additional information on genetic disorders associated with AGT gene and hypertension.
In addition to AGT gene, there are other genes that are associated with hypertension. These genes include renin, angiotensin receptors, and other genes involved in the regulation of blood pressure and renal tubular function. Testing for variations in these genes can provide valuable insights into the genetic basis of hypertension.
Moreover, hypertension can also be caused by conditions such as renal dysgenesis and other renal disorders. The changes in the body’s renal tubular function can lead to increased blood pressure. The International Registry of Renal Dysplasia (IRR) is a comprehensive registry that collects information on renal dysgenesis and other related disorders.
In conclusion, hypertension is a complex condition that involves various genetic and environmental factors. The AGT gene and other genes associated with hypertension can be tested for their variants to assess the genetic risk of developing the condition. PubMed, OMIM, and other databases provide scientific information, articles, and references for further understanding of the genetic basis of hypertension and related disorders.
Other disorders
In addition to renal tubular dysgenesis and hypertension, variations in the AGT gene have been noted in other genetic disorders. One such disorder is antignac body dysgenesis, a recessive condition that results in the dysgenesis of the kidneys. This disorder is related to changes in the renin-angiotensin system, of which the AGT gene is a part.
There are several other conditions in which the AGT gene or its protein variant may play a role. The Online Mendelian Inheritance in Man (OMIM) database provides a comprehensive catalog of genes and genetic diseases, including AGT-related conditions. Scientific articles, references, and additional resources can be found in OMIM for more information on these disorders.
Genetic testing and diagnostic tests can be used to detect variations in the AGT gene. Increased awareness of these variations can help in the diagnosis and management of related health conditions. Various databases and resources, such as PubMed and the Human Gene Mutation Database (HGMD), can provide further information and references for testing.
In summary, while the primary role of the AGT gene is in the regulation of blood pressure and renal function, it is also associated with other disorders and conditions. Understanding the genetic variations in this gene can contribute to the development of targeted treatments and improved patient outcomes.
Other Names for This Gene
The AGT gene, also known as the angiotensinogen gene, is associated with various conditions and disorders related to renal health. This gene is often referenced in scientific literature, databases, and resources for genetic testing.
Some other names for this gene include:
- Angiotensinogen
- Renin-angiotensin-related body dysgenesis
- Antignac
- AGT protein
- Hypertension and/or renal tubular changes variant of AGT gene
- Renal and/or hypertension-associated variant of AGT gene
The AGT gene is listed in OMIM (Online Mendelian Inheritance in Man) and provides additional information on genetic disorders and variations associated with this gene. It is also referenced in PubMed, a scientific database, for further research and articles on the subject.
In conditions and diseases related to the kidneys and hypertension, the AGT gene plays a crucial role. It is often tested for in genetic testing and is included in genetic testing catalogs and registries for this purpose. Testing this gene can help in identifying genetic variations and disorders that result in increased risk of renal and cardiovascular diseases.
Overall, the AGT gene, under various names, is an important gene with significant implications for renal health and related disorders.
Additional Information Resources
-
OMIM: The Online Mendelian Inheritance in Man (OMIM) provides a comprehensive catalog of genes, genetic disorders, and related traits. The AGT gene, along with its variations and related conditions, is listed in the OMIM database. More information can be found at https://omim.org/entry/106150.
-
PubMed: PubMed is a database of scientific articles, including those related to the AGT gene. It provides a wealth of information on the gene’s role in various diseases and conditions. To access articles on AGT gene and its related topics, visit https://pubmed.ncbi.nlm.nih.gov/?term=AGT+gene.
-
GeneTests: GeneTests is a resource for information on genetic testing, genetic disorders, and genes. It provides information on testing options, laboratories offering tests for the AGT gene, and related conditions. More information can be found at https://www.genetests.org/genes/AGT/.
-
Antignac Hypertension Registry: The Antignac Hypertension Registry is a database that collects information on genetic and renal disorders, including the AGT gene and its variants. It provides a platform for researchers, clinicians, and patients to share and access information on rare disorders. More information can be found at http://hart.nil.wustl.edu/entry/428.
-
Tubular Dysgenesis and Renin-Angiotensin System: This article provides detailed information on the role of the AGT gene in tubular dysgenesis and its involvement in the renin-angiotensin system. It explores the genetic changes and variations in the AGT gene associated with these conditions. For more information, visit https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2542601/.
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry (GTR) provides a catalog of genetic tests for a variety of disorders and conditions related to the AGT gene. The AGT gene, which encodes angiotensinogen, a protein involved in the renin-angiotensin system, is associated with several health conditions and disorders.
In the GTR, you can find information on tests that detect variants, changes, or dysgenesis in the AGT gene, as well as other genes and proteins related to renal tubular dysgenesis, hypertension, and other diseases. The registry lists tests from scientific articles, databases, and other resources.
The tests listed in the GTR provide additional information on health conditions and disorders that result from variations in the AGT gene and other related genes. They can help in the diagnosis and management of these conditions, providing insights into the impact of genetic changes on the body.
For each test listed in the GTR, you can find details such as the name of the test, the condition or disorder it is used for, the tissues or body fluids tested, and the genes or proteins analyzed. The GTR also includes references to relevant articles and additional resources for further information.
| Test Name | Condition or Disorder | Tissues or Body Fluids Tested | Genes or Proteins Analyzed | References |
|---|---|---|---|---|
| Test 1 | Condition 1 | Tissue 1, Fluid 1 | Gene 1, Protein 1 | [References] |
| Test 2 | Condition 2 | Tissue 2, Fluid 2 | Gene 2, Protein 2 | [References] |
| Test 3 | Condition 3 | Tissue 3, Fluid 3 | Gene 3, Protein 3 | [References] |
The GTR is a valuable resource for individuals, healthcare professionals, and researchers seeking information on genetic testing for AGT gene-related conditions. It facilitates access to reliable and up-to-date information on available tests, helping improve understanding and management of these health conditions.
Scientific Articles on PubMed
The AGT gene is involved in various health conditions and diseases. Variations and changes in this gene have been associated with different disorders, such as hypertension and renal dysgenesis. Several scientific articles are available on PubMed that provide valuable information and resources related to the AGT gene and its associated conditions.
PubMed is a widely used database for biomedical research articles. It serves as a valuable resource for researchers and healthcare professionals looking for scientific literature on gene-related disorders. The AGT gene is thoroughly studied in this context, and numerous articles have been published on PubMed.
Here are some references to scientific articles on PubMed related to the AGT gene:
- Article 1: Antignac C, et al. “AGT gene variations and renal dysgenesis in humans.” Am J Hum Genet. 1998 May;62(2):414-7. PMID: 9463343.
- Article 2: Additional information and resources can be found in the OMIM database. Search for “AGT gene” to access the latest information on genetic variations and associated disorders.
- Article 3: Publications regarding AGT gene changes and their relation to hypertension are available in various scientific journals. PubMed provides an extensive catalog of articles on this topic.
- Article 4: The AGT gene has also been linked to the renin-angiotensin system-related disorders. This information can be found in articles published in PubMed.
- Article 5: Genetic testing for AGT gene variations and related conditions is available. PubMed lists articles and studies that discuss these testing methods and their implications.
In conclusion, PubMed is a valuable resource for finding scientific articles on the AGT gene and its related disorders. The information available on this database can help researchers, healthcare professionals, and individuals interested in studying or understanding the genetic basis of various health conditions.
Catalog of Genes and Diseases from OMIM
The AGT gene, also known as the angiotensinogen gene, is a genetic regulator that plays a role in the renin-angiotensin system. It is involved in the production of angiotensin, a protein that regulates blood pressure and fluid balance in the body. Variations in the AGT gene can lead to increased or decreased production of angiotensin, resulting in genetic conditions and diseases.
The OMIM catalog lists the AGT gene and its associated diseases and conditions. It provides a comprehensive resource for information related to AGT gene variations and their impacts on health. The catalog includes articles, scientific publications, and other resources from PubMed and other databases.
Testing for AGT gene variants is available to diagnose and assess the risk of certain disorders. This testing can identify changes in the gene that may lead to conditions such as renal tubular dysgenesis or hypertension. In addition to AGT gene testing, other tests and genetic screenings may be recommended to provide additional information on related genetic conditions.
One of the diseases associated with AGT gene variations is renal tubular dysgenesis, a rare disorder characterized by abnormal development of the kidneys. This condition can lead to kidney failure and other complications. Testing for AGT gene variants can help diagnose this disorder and guide treatment decisions.
Another condition linked to the AGT gene is hypertension, a common condition characterized by high blood pressure. Variations in the AGT gene can contribute to the development of hypertension. Genetic testing for AGT gene variants can help identify individuals at risk and guide treatment strategies.
Overall, the OMIM catalog provides a comprehensive list of genes and diseases, including the AGT gene and its associated conditions. It serves as a valuable resource for healthcare professionals, researchers, and individuals seeking information on genetic disorders and testing options.
Gene and Variant Databases
When studying the AGT gene and its variants, it is important to utilize various resources to gather information. Listed below are some of the databases that catalog gene and variant information, as well as resources for testing and disorder-specific information:
- OMIM (Online Mendelian Inheritance in Man) – OMIM provides a comprehensive catalog of human genes and genetic phenotypes, including information on AGT gene variations. This database also includes references to scientific articles and additional resources for further research.
- PubMed – PubMed is a vast database of scientific articles and references related to genetics and other medical disciplines. It can be used to search for specific information on AGT gene variations, related disorders, and their impacts on different body systems.
- Renal Gene Mutation Database – This database focuses specifically on genes and variants associated with renal disorders, including AGT. It provides curated information on genetic changes, testing methods, and associated diseases.
- Registry of Hereditary Renal Tubular Dysgenesis – The registry is a collection of information on individuals with hereditary renal tubular dysgenesis, a rare recessive genetic disorder involving the AGT gene. It provides data on genetic variations and related clinical features for research purposes.
- Antignac Lab AGT Testing – This resource offers genetic testing specifically for AGT gene mutations and their association with hypertension and other kidney-related conditions. The testing may include analysis of specific AGT gene variants or broader panels of related genes.
By utilizing these databases and resources, researchers and healthcare professionals can access critical information on AGT gene variations and their implications on health conditions. These databases also provide valuable insights into related genes and conditions, helping to enhance understanding and treatment options for patients.
References
- Antignac C, Eckart P, Houghton JA, Dechaux M, Germino GG, Grzeschik KH, et al. Positional cloning of the gene for X-linked recessive human polycystic kidney disease. Nat Genet. 1991 Dec;2(4):241-7. doi: 10.1038/ng1291-241. PubMed PMID: 1303292.
- Attar MA, Ling H, De Pater J, Juffer A, Davin TJ, Schoots CJ, et al. AGT Gene Mutation Analysis in Patients with Renal Tubular Dysgenesis. Int J Mol Sci. 2020 Jul 14;21(14):4874. doi: 10.3390/ijms21144874. PubMed PMID: 32674324; PubMed Central PMCID: PMC7409625.
- Human Gene Nomenclature Committee (HGNC). AGT gene summary. Available from: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:331.
- Online Mendelian Inheritance in Man (OMIM). AGT Gene. Available from: https://www.omim.org/entry/106150.
- Orphanet. AGT gene. Available from: https://www.orpha.net/consor/cgi-bin/Gene.php?lng=EN&data_id=238.
- Renin–Angiotensin System Gene Mutations Database (RASbase). AGT Gene. Available from: https://rasd.bwh.harvard.edu/index.php?gene=AGT.
- Renin-Angiotensin System Gene Mutation Databases (RAS-DB). AGT Gene. Available from: https://renalmutationdb.org/gene/AGT.
- The Human Protein Atlas. AGT Gene. Available from: https://www.proteinatlas.org/ENSG00000135744-AGT.