Bevacizumab Injection

Bevacizumab injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to bevacizumab injection and work the same way as bevacizumab injection in the body. Therefore, the term bevacizumab injection products will be used to represent these medications in this discussion.

🔔 Why is this medication prescribed?

Bevacizumab injection products are used in combination with other chemotherapy medications to treat certain types of colon and rectal cancer (cancer that begins in the large intestine), non-small cell lung cancer (NSCLC), glioblastoma (a certain type of cancerous brain tumor), renal cell cancer (RCC, a type of cancer that begins in the kidney), cervical cancer (cancer that begins in the opening of the uterus [womb]), and ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), or peritoneal (layer of tissue that lines the abdomen) cancer. Bevacizumab (Avastin) is also used in combination with atezolizumab (Tecentriq) to treat hepatocellular carcinoma (HCC) that has spread or cannot be removed by surgery in people who have not previously received chemotherapy. Bevacizumab injection products are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumors. This may slow the growth and spread of tumors.

🔔 How should this medicine be used?

Bevacizumab injection products come as a solution (liquid) to administer slowly into a vein. Bevacizumab injection products are administered by a doctor or nurse in a medical office, infusion center, or hospital. Bevacizumab injection products are usually given once every 2 or 3 weeks. Your dosing schedule will depend on the condition that you have, the other medications you are using, and how well your body responds to treatment.

It should take 90 minutes for you to receive your first dose of a bevacizumab injection product. A doctor or nurse will watch you closely to see how your body reacts to bevacizumab. If you do not have any serious problems when you receive your first dose of a bevacizumab injection product, it will usually take 30 to 60 minutes for you to receive each of your remaining doses of the medication.

Bevacizumab injection products may cause serious reactions during infusion of the medication. If you experience any of the following symptoms, tell your doctor immediately: difficulty breathing or shortness of breath, chills, shaking, sweating, headaches, chest pain, dizziness, feeling faint, flushing, itching, rash, or hives. Your doctor may need to slow down your infusion, or delay or stop your treatment if you experience these or other side effects.

🔔 Other uses for this medicine

Bevacizumab injection (Avastin) is also sometimes used to treat wet age-related macular degeneration (AMD; an ongoing disease of the eye that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities) and diabetic macular edema (an eye disease caused by diabetes that can lead to vision loss). Talk to your doctor about the risks of using bevacizumab to treat your condition.

Patients, too, are unhappy with the care they receive during those brief interactions with their doctors. Healthcare communications company West Corporation reported that 25% of patients don’t feel that their provider cares about them as an individual and nearly 20% aren’t convinced their doctor is focused on improving their health – even though 93% of doctors strongly agree that patient satisfaction is important.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

🔔 What special precautions should I follow?

Before receiving a bevacizumab injection product,

• tell your doctor and pharmacist if you are allergic to bevacizumab, bevacizumab-adcd, bevacizumab-awwb, bevacizumab-bvzr, bevacizumab-maly, any other medications, or any of the ingredients in bevacizumab injection products.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you have ever been treated with radiation therapy to the left side of your chest or pelvis; and if you have or have ever had bleeding problems, diabetes, high blood pressure, heart failure, angina (chest pain that comes at rest with no obvious cause), heart attack, stroke or transient ischemic attacks (TIA), or blood clots in your lungs or legs. Also, tell your doctor if you have recently coughed up blood.
• you should know that bevacizumab injection products may cause infertility in women (difficulty becoming pregnant); however, you should not assume that you cannot get pregnant. Tell your doctor if you are pregnant or plan to become pregnant. You should use birth control to prevent pregnancy during your treatment with a bevacizumab injection product and for at least 6 months after your final dose. If you become pregnant while using a bevacizumab injection product, call your doctor. Bevacizumab may harm the fetus and increase the risk of a pregnancy loss.
• tell your doctor if you are breastfeeding. You should not breastfeed during your treatment with a bevacizumab injection product and for at least 6 months after your final dose.
• you should know that this medication may cause ovarian failure. Talk to your doctor about the risk of infertility in women caused by bevacizumab.
• tell your doctor if you have recently had surgery or if you plan to have surgery, including dental surgery. If you are scheduled to have surgery, your doctor will stop your treatment with an bevacizumab injection product at least 28 days before the surgery. If you have recently had surgery, you should not receive an bevacizumab injection product until at least 28 days have passed and until the area has completely healed.