Diroximel Fumarate
Diroximel fumarate is used to treat adults with various forms of multiple sclerosis (MS; a disease in which the nerves do not function properly and people may experience weakness, numbness, loss of muscle coordination, and problems with vision, speech, and bladder control) including:
- clinically isolated syndrome (CIS; nerve symptom episodes that last at least 24 hours),
- relapsing-remitting forms (course of disease where symptoms flare up from time to time), or
- secondary progressive forms (course of disease where relapses occur more often).
Diroximel fumarate is in a class of medications called Nrf2 activators. It works by decreasing inflammation and preventing nerve damage that may cause symptoms of multiple sclerosis.
🔔 How should this medicine be used?
Diroximel fumarate comes as a delayed-release (releases the medication in the intestine to prevent breakdown of the medication by stomach acids) capsule to take by mouth. It is usually taken twice daily. Take diroximel fumarate at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take diroximel fumarate exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Diroximel fumarate may be taken with or without food. However, do not take it with a high-fat, high-calorie meal or snack; the meal or snack must contain less than 700 calories and less than 30 grams of fat.
Do not drink alcoholic beverages at the same time you take diroximel fumarate.
Swallow the delayed-release capsules whole; do not split, chew, crush, or sprinkle them.
Preventable medical errors kill about 22,000 patients a year, according to research from the Yale School of Medicine. That’s much less than a previously reported number of 250,000 deaths a year where medical error is to blame.
You may take a non-enteric coated aspirin (325 mg or less) 30 minutes before taking diroximel fumarate to reduce the chance of flushing (facial redness) during your treatment.
Your doctor will probably start you on a low dose of diroximel fumarate and increase your dose after 7 days.
Diroximel fumarate may help to control multiple sclerosis, but will not cure it. Continue to take diroximel fumarate even if you feel well. Do not stop taking diroximel fumarate without talking to your doctor.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
