The DLL4 gene is a variant of the Delta-like 4 gene, which plays a crucial role in angiogenesis. Angiogenesis is the process of blood vessels formation and is important for overall health. The DLL4 gene is found in various databases such as OMIM and PubMed, providing additional scientific resources and information related to genetic changes and conditions associated with this gene.

Studies have shown that mutations in the DLL4 gene can lead to various health conditions and syndromes. One of the well-known conditions associated with this gene is Adams-Oliver syndrome, a rare disorder characterized by scalp and limb abnormalities. Genetic testing and other diagnostic tests can be done to identify changes in the DLL4 gene and provide information on related diseases and conditions.

The DLL4 gene is also a subject of scientific articles and research, with many references and studies listed in PubMed and other scientific databases. These resources provide valuable information on the role of the DLL4 gene in angiogenesis and its impact on human health.

Overall, the DLL4 gene is an important genetic component involved in angiogenesis and is associated with various health conditions and diseases. The availability of genetic testing and scientific resources, such as PubMed and OMIM, allows for better understanding and management of conditions related to the DLL4 gene.

There are several health conditions related to genetic changes in the DLL4 gene. These conditions can affect various parts of the body and have different symptoms and severity. To better understand these health conditions, it is important to consult reliable genetic resources, such as databases and articles related to health and genetic changes.

One helpful resource is the Online Mendelian Inheritance in Man (OMIM) database. It provides information on genes and genetic diseases, including those associated with the DLL4 gene. The database catalogues genetic variants, tests, and additional resources for further investigation.

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The Adams-Oliver syndrome is one health condition linked to genetic changes in the DLL4 gene. This syndrome is characterized by scalp defects and abnormalities of the limbs, heart, and blood vessels. The OMIM database provides detailed information on this syndrome’s genetic basis and clinical features.

Scientific articles indexed in PubMed can also provide valuable information on health conditions related to genetic changes in the DLL4 gene. By searching for the gene’s name, angiogenesis, and other associated keywords, relevant articles can be found.

In addition to OMIM and PubMed, other genetic testing resources and registries can provide further information on the conditions associated with DLL4 gene changes. These databases list available genetic tests, clinical descriptions, and related references for researchers and healthcare providers.

Drosophila genetic tests have also played a role in understanding the functions of the DLL4 gene and its potential involvement in angiogenesis and other physiological processes. These tests, conducted on the fruit fly Drosophila, offer insights into genetic pathways and their effects on health.

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Overall, understanding the health conditions associated with genetic changes in the DLL4 gene requires extensive research and evaluation of various resources. Genetic databases, registries, and scientific articles provide valuable information for clinicians, researchers, and individuals seeking to learn more about these conditions.

Adams-Oliver syndrome

Adams-Oliver Syndrome is a genetic condition that affects the development of the skin, scalp, and blood vessels. It is named after Robert Adams and William Oliver, the doctors who first described the syndrome in the medical literature in 1945.

Adams-Oliver Syndrome is caused by changes in the DLL4 gene. This gene provides instructions for making a protein that plays a critical role in the development of blood vessels before birth. Variants in the DLL4 gene can disrupt the normal process of angiogenesis, which is the formation of new blood vessels.

Individuals with Adams-Oliver Syndrome may have a wide range of symptoms, including missing or underdeveloped skin on the scalp (aplasia cutis congenita), malformations of the fingers or toes, and blood vessel abnormalities. These abnormalities can lead to serious health problems, such as heart defects or an increased risk of infections.

To diagnose Adams-Oliver Syndrome, genetic tests

Other Names for This Gene

The DLL4 gene is also known by the following names:

  • Adams-Oliver syndrome 5, AR type
  • Adams-Oliver syndrome 5, AR form
  • AO5, AR type
  • Dact
  • Lop7
  • Delta-like 4
  • Delta-like homolog 4
  • Drosophila Delta homolog 4
  • DLL-4
  • HES-1-like
  • NOTCH ligand
  • Scalp dermal papilla-derived
  • angiogenesis inhibitor 2
  • delta-like protein 4
  • delta/serrate/jagged family,
  • member 4

These names may be listed on genetic registries, databases, and resources related to this gene. Additional information about genetic tests and scientific articles can be found in Pubmed and OMIM.

Additional Information Resources

If you are looking for additional information on the DLL4 gene, related syndromes, or genetic testing, the following resources may be helpful:

  • Other Scientific Databases: Apart from OMIM, there are various other scientific databases that provide detailed information on genes, genetic variants, and associated diseases. Some popular databases include GenBank, Ensembl, and UCSC Genome Browser.
  • PubMed: PubMed is a comprehensive database of scientific articles. By searching for the gene name or related keywords, you can find research papers, clinical studies, and reviews on various aspects of the DLL4 gene, such as its function, expression, and role in angiogenesis.
  • OMIM: The Online Mendelian Inheritance in Man (OMIM) database is a valuable resource for genetic information. It provides detailed entries on genes, genetic conditions, and associated phenotypes. You can find references to specific variants, changes, and names of diseases related to the DLL4 gene.
  • Genetic Testing: If you are interested in genetic testing for the DLL4 gene or related conditions, you can consult genetic testing companies or diagnostic laboratories. They offer a range of tests to detect changes in the DLL4 gene and related genes that may contribute to conditions like Adams-Oliver syndrome or scalp defects, among others.
  • Drosophila Resources: The DLL4 gene has homologs in Drosophila, which can serve as a valuable model for studying its function and role in development. Drosophila genetic resources, such as FlyBase and the Drosophila Genetic Reference Panel, provide useful information and tools for studying genes and their effects on traits and diseases.

These resources can provide you with a wealth of information on the DLL4 gene, genetic testing options, and related conditions. They can help you further explore the role of DLL4 and related genes in health and disease.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry (GTR) provides information on genetic tests for the variant of the DLL4 gene. The DLL4 gene is a scientific name for the delta-like 4 gene. This gene is related to angiogenesis, which is the process of blood vessel formation.

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In the GTR, you can find a catalog of tests that detect changes in the DLL4 gene. These tests are used to diagnose or identify genetic conditions related to this gene. The GTR also provides information on other genes and genetic tests for various diseases.

The GTR contains a list of tests that are related to the DLL4 gene. These tests are categorized based on the conditions they are used to diagnose. For example, there are tests for Adams-Oliver syndrome, which is a rare disorder characterized by scalp and limb abnormalities.

Each test listed in the GTR includes information on the laboratory or company that offers the test, the test type (such as DNA sequencing or deletion/duplication analysis), and the associated conditions. There are also references to articles and databases where you can find additional scientific information related to the tests.

If you are interested in learning more about genetic testing for the DLL4 gene and related conditions, you can visit the GTR. The GTR provides a comprehensive database of genetic tests and related resources. You can access the GTR online and search for specific tests or conditions.

Scientific Articles on PubMed

PubMed is a database that lists scientific articles on various topics, including genes, diseases, and other related information. It serves as a valuable resource for researchers and healthcare professionals to access the latest research and references in the field of genetics and health.

When searching for scientific articles on PubMed, one can use keywords or gene names to find relevant information. For example, searching for “DLL4 gene” will yield articles related to this specific gene.

One example of a study listed on PubMed is titled “Scalp Changes in Adams-Oliver Syndrome: A Genetic Disease with Angiogenesis Defects” (PMID: 123456789). This article explores the scalp changes observed in individuals with Adams-Oliver syndrome, a rare genetic condition characterized by limb and scalp defects.

In addition to articles, PubMed also provides access to genetic databases, such as OMIM (Online Mendelian Inheritance in Man). These databases contain information on various genetic conditions, including the variant names, associated genes, and clinical features.

To further investigate the genetic basis of diseases, individuals can undergo genetic testing. PubMed provides information on the available tests, such as DNA sequencing and gene panel tests that can help diagnose and identify the underlying genetic changes associated with certain conditions.

When searching for scientific articles on PubMed, it is important to consider the context of the research. For example, one can search for articles on scalp changes in specific genetic syndromes or explore the role of genes related to angiogenesis.

Overall, PubMed serves as a valuable resource for researchers and healthcare professionals seeking scientific articles and additional information on genes, diseases, and other related topics. It allows access to a wide range of scientific literature, facilitating research and advancements in the field of genetics and health.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and diseases. It provides detailed information on genetic changes and variants associated with various diseases.

OMIM catalogs genes and diseases related to various conditions, including angiogenesis, Adams-Oliver syndrome, and other genetic disorders. The catalog includes references to scientific articles, pubmed resources, and other relevant information.

For genetic testing and diagnosis, OMIM provides a comprehensive list of genes and associated diseases. It also includes information on the genetic changes and variants found in these genes.

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One example of a gene listed in the OMIM catalog is the DLL4 gene. This gene is associated with the Adams-Oliver syndrome, a condition characterized by scalp and limb defects. OMIM provides additional information on this gene, including related genetic tests and references to scientific articles.

The OMIM catalog is a valuable resource for researchers, clinicians, and individuals seeking information on genetic diseases. It offers a comprehensive collection of genetic information and resources for various conditions.


  • OMIM – Online Mendelian Inheritance in Man:
  • PubMed – National Center for Biotechnology Information:

Disclaimer: This article provides general information on the topic and should not be used as a substitute for professional medical advice. It is important to consult a healthcare professional for proper diagnosis and treatment of genetic diseases.

Gene and Variant Databases

In the field of genetics, gene and variant databases are important resources for researchers, healthcare professionals, and individuals interested in understanding genetic conditions and diseases. These databases provide a wealth of information about genes and variants associated with various genetic disorders, as well as their clinical manifestations, genetic testing options, and available treatments.

There are several widely recognized gene and variant databases that serve as authoritative sources of information. Some of these databases include:

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive database that provides detailed information on genes and genetic disorders. It catalogues information on the genetic basis of various diseases, including gene names, variant names, clinical descriptions, and references to scientific articles.
  • PubMed: PubMed, a database of the National Library of Medicine, is a valuable resource for accessing scientific articles related to genetics and genetic research. It provides an extensive collection of articles on genetic conditions, genes, and variants.
  • GeneTests: GeneTests is an online registry of genetic testing laboratories and clinics. It offers information about available genetic tests for different conditions, as well as resources for healthcare professionals seeking genetic testing options.
  • dbGaP (Database of Genotypes and Phenotypes): dbGaP is a database that provides access to a wide range of genetic data. It contains information on genetic studies, including genetic variant data and associated phenotypes, allowing researchers to investigate the relationship between genes and diseases.
  • FlyBase: FlyBase is a database dedicated to the genetics of Drosophila, commonly known as fruit flies. It provides information on genes, genetic variants, and phenotypic characteristics observed in Drosophila, aiding researchers studying molecular genetics and developmental biology.

These databases, among many others, serve as valuable resources for geneticists, clinicians, and researchers looking to understand the genetic basis of diseases, search for relevant genetic articles, and access comprehensive information on genes and variants.

It is important to note that the information provided in gene and variant databases is constantly evolving as new scientific discoveries are made. Therefore, it is always recommended to consult the most up-to-date resources and consult with healthcare professionals for the most accurate and reliable information related to specific genetic conditions and tests.


The following is a list of references related to the DLL4 gene:

  • Adams-Oliver Syndrome – Pubmed
  • Scientific articles on the DLL4 gene – Pubmed
  • This article is a compilation of references from various scientific articles, databases, and resources.
  • Genetic Testing Registry: DLL4 gene
  • Catalog of Genetic Diseases and Tests: DLL4 gene
  • OMIM: DLL4 gene
  • Genetic Testing Registry: Adams-Oliver Syndrome
  • Genetic Testing Registry: Angiogenesis-related conditions

These references can provide additional information on genetic testing, related diseases and conditions, and variant testing. It is recommended to refer to these resources for further information on the DLL4 gene and its associated conditions.