Estrogen Vaginal

Estrogen increases the risk that you will develop endometrial cancer (cancer of the lining of the uterus [womb]) during your treatment or up to 15 years after your treatment, if you have not had a hysterectomy (surgery to remove the uterus [womb]). The longer you use estrogen, the greater the risk that you will develop endometrial cancer. If you have not had a hysterectomy, you may be given another medication called a progestin to take with vaginal estrogen. This may decrease your risk of developing endometrial cancer but may increase your risk of developing certain other health problems, including breast cancer. Before you begin using vaginal estrogen, tell your doctor if you have or have ever had cancer and if you have unusual vaginal bleeding. Your doctor may tell you not to use vaginal estrogen. Call your doctor immediately if you have abnormal or unusual vaginal bleeding during your treatment with vaginal estrogen. Your doctor will watch you closely to help ensure you do not develop endometrial cancer during or after your treatment.

In a large study, women who took estrogen with progestins by mouth had a higher risk of heart attacks, strokes, blood clots in the lungs or legs, breast cancer, and dementia (loss of ability to think, learn, and understand). Women who use vaginal estrogen alone or with progestins may also have a higher risk of developing these conditions. Tell your doctor if you have had a heart attack or a stroke, if you or anyone in your family has or has ever had blood clots or breast cancer. or if you have any condition that increases the risk that you will develop blood clots. Your doctor may tell you not to use vaginal estrogen. Also tell your doctor if you if you smoke or use tobacco, and if you have or have ever had high blood pressure, high blood levels of cholesterol or fats, diabetes, heart disease, lupus (a condition in which the body attacks its own tissues causing damage and swelling), breast lumps, or an abnormal mammogram (x-ray of the breasts used to find breast cancer).

The following symptoms can be signs of the serious health conditions listed above. Call your doctor immediately if you experience any of the following symptoms while you are using vaginal estrogen: sudden, severe headache; sudden, severe vomiting; speech problems; dizziness or faintness; sudden complete or partial loss of vision; double vision; weakness or numbness of an arm or a leg; crushing chest pain or chest heaviness; coughing up blood; sudden shortness of breath; difficulty thinking clearly, remembering, or learning new things; breast lumps or other breast changes; discharge from nipples; or pain, tenderness, or redness in one leg.

You can take steps to decrease the risk that you will develop a serious health problem while you are using vaginal estrogen. Do not use vaginal estrogen alone or with a progestin to prevent heart disease, heart attacks, strokes, or dementia. Use the lowest dose of estrogen that controls your symptoms and only use vaginal estrogen as long as needed. Talk to your doctor every 3 to 6 months to decide if you should use a lower dose of estrogen or should stop using the medication.

You should examine your breasts every month and have a mammogram and a breast exam performed by a doctor every year to help detect breast cancer as early as possible. Your doctor will tell you how to properly examine your breasts and whether you should have these exams more often than once a year because of your personal or family medical history.

Tell your doctor if you are having surgery or will be on bed rest. Your doctor may tell you to stop using vaginal estrogen 4 to 6 weeks before the surgery or bed rest to decrease the risk that you will develop blood clots.

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Talk to your doctor regularly about the risks and benefits of using vaginal estrogen.

🔔 Why is this medication prescribed?

Vaginal estrogen is used to treat vaginal dryness, itching, and burning; painful or difficult urination; and sudden need to urinate immediately in women who are experiencing or have experienced menopause (change of life; the end of monthly menstrual periods). Femring ® brand vaginal ring is also used to treat hot flushes (‘hot flashes’; sudden strong feelings of heat and sweating) in women who are experiencing menopause. Premarin ® brand vaginal cream is also used to treat kraurosis vulvae (a condition that may cause vaginal dryness and discomfort in women or girls of any age). Imvexxy ® brand vaginal inserts are used for the treatment of dyspareunia (difficult or painful sexual intercourse) in menopausal women. Vaginal estrogen is in a class of medications called hormones. It works by replacing estrogen that is normally produced by the body.

🔔 How should this medicine be used?

Vaginal estrogen comes as a flexible ring, a vaginal insert, as a tablet to insert in the vagina, and as a cream to apply to the inside of the vagina. Estrogen vaginal rings are usually inserted in the vagina and left in place for 3 months. After 3 months, the ring is removed, and a new ring may be inserted if treatment is still needed. Vaginal estrogen inserts are usually inserted once daily at the same time for 2 weeks, then used once every 3 to 4 days (twice weekly) as long as treatment is needed. Estrogen vaginal tablets are usually inserted once a day for the first 2 weeks of treatment and then are inserted twice a week as long as treatment is needed. Estrace ® brand vaginal cream is usually applied once daily for 2 to 4 weeks, and then applied one to three times a week. Premarin ® brand vaginal cream product is usually applied according to a rotating schedule that alternates several weeks when the cream is applied every day with one week when the cream is not applied. Use vaginal estrogen at around the same time of day every time you use it. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use vaginal estrogen exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

To use the vaginal ring, follow these steps:

1. Wash and dry your hands.
2. Remove the vaginal ring from its pouch.
3. Stand with one leg up on a chair, step or other object, squat, or lie down. Choose the position that is most comfortable for you.
4. Hold the vaginal ring between your thumb and index finger and press the sides of the ring together. You may want to twist the ring into a figure-eight shape.
5. Hold open the folds of skin around your vagina with your other hand.
6. Place the tip of the ring into your vagina and then use your index finger to gently push the ring inside your vagina as far as you can.
7. The vaginal ring does not have to be positioned a certain way inside your vagina, but it will be more comfortable and less likely to fall out when it is placed as far back in your vagina as possible. The ring cannot go past your cervix, so it will not go too far in your vagina or get lost when you push it in. If you feel discomfort, use your index finger to push the ring further into your vagina.
8. Wash your hands again.
9. Leave the ring in place for 3 months. The ring may fall out if you have not inserted it deeply in your vagina, if your vaginal muscles are weak, or if you are straining to have a bowel movement. If the ring falls out, wash it with warm water and replace it in your vagina following the directions above. Do not use hot water to rinse the ring. If the ring falls out and is lost, insert a new ring and leave the new ring in place for up to 3 months. Call your doctor if your ring falls out often.
10. You can leave the ring in place when you have sex. If you choose to remove it or if it falls out, wash it with warm water and replace it in your vagina as soon as possible.
11. When you are ready to remove the ring, wash your hands and stand or lie in a comfortable position.
12. Put a finger into your vagina and hook it through the ring. Gently pull downward and forward to remove the ring.
13. Wrap the ring in a tissue or a piece of toilet paper and dispose of it safely, so that it is out of reach of children or pets. Do not flush the ring in a toilet.
14. Wash your hands again.

To use the vaginal tablet, follow these steps:

1. Tear off one applicator from the strip of applicators in your carton.
2. Open the plastic wrap and remove the applicator.
3. Stand with one leg up on a chair, step, or other object, or lie down. Choose the position that is most comfortable for you.
4. Hold the applicator in one hand with a finger on the end of the plunger.
5. Use the other hand to gently guide the applicator into the vaginal opening. If the tablet falls out of the applicator, do not try to replace it. Dispose of that applicator and tablet and use a fresh applicator.
6. Insert the applicator into your vagina as far as is comfortable. Do not force the applicator into your vagina or insert more than half of the applicator into your vagina.
7. Gently press the plunger until you hear a click.
8. Remove the empty applicator from your vagina and dispose of it as you would a plastic tampon applicator. Do not save or reuse the applicator.

To use the vaginal insert (Imvexxy ® ), follow these steps:

1. Wash and dry your hands before handling the vaginal insert.
2. Push one vaginal insert through the foil of the blister package.
3. Hold the vaginal insert with the larger end between your fingers.
4. Select the best insertion position for vaginal insertion either lying down or standing,
5. With the smaller end up, put the insert about 2 inches into your vagina using your finger.

To use the vaginal cream, follow these steps:

1. Remove the cap from the tube of cream.
2. Screw the nozzle or threaded end of the applicator onto the open end of the tube.
3. Gently squeeze the tube from the bottom to fill the applicator with the amount of cream that your doctor has told you to use. Look at the markings on the side of the applicator to help measure your dose.
4. Unscrew the applicator from the tube.
5. Lie on your back and pull your knees up toward your chest.
6. Gently insert the applicator into your vagina and press the plunger downward to release the cream.
7. Remove the applicator from your vagina.
8. To clean the applicator, pull the plunger to remove it from the barrel. Wash the applicator and plunger with mild soap and warm water. Do not use hot water or boil the applicator.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.