The F13A1 gene is one of the many genes listed in the catalog of genes that play a role in various factors related to health and diseases. This gene is responsible for encoding the factor XIII-A protein, which is part of the blood clotting process.
Deficiency in the factor XIII-A protein can lead to abnormalities in blood clotting, resulting in a higher risk of bleeding. This condition is known as Factor XIII Deficiency, and it is a rare genetic disorder.
Scientists have conducted various studies and research articles related to the F13A1 gene and its variant forms. OMIM and PubMed are databases that provide additional information about the gene, its functions, and its association with various diseases and conditions.
Testing for F13A1 gene variants can be done through specialized tests and genetic testing. These tests can provide valuable information for diagnosing and managing disorders related to blood clotting.
References:
– OMIM: F13A1 gene
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– PubMed: F13A1 gene
In conclusion, the F13A1 gene is an important gene associated with the clotting factor XIII-A. Changes or deficiencies in this gene can lead to various disorders and conditions related to the bloodstream. Scientists and researchers continuously study this gene to understand its functions and develop better resources for testing and managing related diseases.
Health Conditions Related to Genetic Changes
The F13A1 gene provides instructions for making a protein called coagulation factor XIII A subunit (FXIII-A). FXIII-A functions as a clotting factor, which is involved in the process of blood clot formation.
Genetic changes in the F13A1 gene can lead to a deficiency of FXIII-A, resulting in health conditions related to clotting abnormalities. This deficiency can be inherited in an autosomal recessive manner, meaning both copies of the gene must be altered to cause the condition.
Health conditions associated with genetic changes in the F13A1 gene include:
- F13A1 Deficiency: This condition is characterized by a lack of FXIII-A in the bloodstream. It can lead to an increased risk of bleeding, delayed wound healing, and abnormal scar formation.
- Factor XIII Subunit A Deficiency: This is another name for F13A1 deficiency and refers to the specific protein subunit affected by the genetic change.
Additional information on these conditions can be found in scientific databases such as PubMed and OMIM. These resources provide references to articles and other resources related to genetic conditions and diseases.
Diagnostic testing for F13A1 gene changes can be performed to confirm a diagnosis and provide genetic counseling. These tests may involve DNA analysis or other methods to detect specific variants in the gene.
It is important to note that the F13A1 gene is part of a larger network of genes and genetic factors involved in blood clotting. Other genes listed in databases such as PubMed and OMIM may also be related to clotting disorders.
For more information on F13A1 and related genes, you can refer to the following resources:
- F13A1 Gene Entry in the PubMed Database: Provides scientific articles and references on the gene and related topics.
- F13A1 Gene Entry in the OMIM Catalog: Offers information on the gene, its functions, and associated disorders.
- Other Genes Related to Clotting Disorders: Provides a list of genes linked to clotting abnormalities, including genes that interact with F13A1.
By understanding the genetic changes in the F13A1 gene and their associated health conditions, scientists and healthcare professionals can work towards better diagnosis, treatment, and prevention of clotting disorders.
Factor XIII deficiency
Factor XIII deficiency is a rare genetic disorder that affects the bloodstream and prevents the normal clotting process. It is caused by mutations in the F13A1 gene. This gene provides instructions for making a protein called factor XIII A subunit.
F13A1 gene has a name of factor XIII clotting protein. It has been listed in various genetic databases, such as OMIM and PubMed, where detailed information about its functions and related disorders can be found.
Factor XIII A subunit is part of a larger protein complex called factor XIII. This complex plays a key role in the blood clotting process, by helping to stabilize clots and prevent their breakdown. Deficiency in factor XIII activity can lead to excessive bleeding and delayed wound healing.
Factor XIII deficiency is usually inherited in an autosomal recessive manner, meaning that both copies of the F13A1 gene must be mutated for the disorder to occur. However, there are rare cases where the deficiency is inherited in an autosomal dominant manner, with only one copy of the gene being mutated.
Diagnosis of factor XIII deficiency can be done through various genetic tests that detect mutations in the F13A1 gene. Testing for related factors and genes, such as factor XIIIA and other clot-related genes, may also be performed to rule out other conditions.
For individuals diagnosed with factor XIII deficiency, there are resources available for additional information and support. The Factor XIII Registry, listed in various genetic databases, provides a central repository of information on this disorder and connects patients with research studies and clinical trials.
Scientific articles and references on factor XIII deficiency can be found in PubMed, which is a comprehensive database of biomedical literature. These articles provide further insight into the genetic changes, clotting mechanisms, and management of this condition.
In conclusion, factor XIII deficiency is a rare genetic disorder caused by mutations in the F13A1 gene. It affects the clotting process and can lead to excessive bleeding. Further research and testing are needed to better understand the genetic changes and develop effective treatments for this condition.
Other disorders
The F13A1 gene is involved in the development and function of various diseases and conditions. While its main association is with Factor XIII deficiency, there are other disorders where this gene plays a role. Some of the diseases and conditions related to F13A1 gene are:
- Disorders of blood clotting
- Genetic changes and variants
- Deficiency in Factor XIII
- Common clotting disorders
- Conditions related to the bloodstream
These disorders can be diagnosed through genetic tests that assess mutations or changes in the F13A1 gene. Additional information on these diseases and their genetic factors can be found in various scientific resources such as OMIM, PubMed, and other related databases. These databases catalog articles, references, and scientific studies on the function and role of the F13A1 gene in different disorders.
In addition to the F13A1 gene, other genes and factors are involved in these conditions, including other subunits of Factor XIII and various clotting factors. The Registry of Clotting Factor Deficiencies provides further information on these related genes and the diseases they are associated with.
Testing for clotting disorders, especially those related to Factor XIII deficiency, often involves assessing the F13A1 gene and its variants. Genetic tests can identify specific changes in the F13A1 gene that may contribute to these disorders and help in their diagnosis.
References to scientific articles and research papers related to other disorders linked to F13A1 gene can be found in databases like PubMed. These resources provide important information on the characteristics, classifications, and management of these disorders.
Other Names for This Gene
F13A1 gene is also known by several other names:
- Coagulation factor XIII A subunit
- Factor XIII
- F13A gene
- F13A1 subunit
- FXIIIA
- Transglutaminase factor XIII subtype A
- F13A1 antibody
- F13A1 protein
These alternative names are commonly used in scientific articles, databases, and resources related to genetic factors, clotting disorders, and related health conditions.
Additional Information Resources
Here are some additional resources for more information about the F13A1 gene:
- PubMed: A database of scientific articles on genetics and related topics. You can search for articles about the F13A1 gene and its functions, diseases, and genetic changes. (PubMed)
- OMIM: The Online Mendelian Inheritance in Man catalog provides information on genes, genetic disorders, and conditions. You can find information on the F13A1 gene, related diseases and conditions, and genetic changes. (OMIM)
- F XIII A deficiency registry: A registry for patients with F XIII deficiency, providing information on the disorder and genetic changes. (F XIII A deficiency registry)
- Catalog of Genes and Diseases: This catalog provides information on genes and genetic disorders. You can find information on the F13A1 gene and related diseases. (Catalog of Genes and Diseases)
- Health testing resources: Resources for genetic testing and information on genes. You can find information on genetic testing for F13A1 gene variants and related factors. (Health testing resources)
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry (GTR) is a catalog of genetic tests and their associated information. It provides a central location for accessing information about genetic tests for various genetic disorders and diseases. The GTR lists several tests related to the F13A1 gene and its associated conditions.
The F13A1 gene encodes the coagulation factor XIII A subunit. Mutations in this gene can lead to Factor XIII deficiency, a rare genetic disorder characterized by abnormal blood clot formation. Testing for variants in the F13A1 gene can help diagnose and determine the genetic causes of Factor XIII deficiency.
Tests listed in the GTR provide information on the specific changes or variants in the F13A1 gene that are associated with Factor XIII deficiency. These tests can detect mutations and provide insights into the genetic factors contributing to abnormal blood clot formation.
The GTR is a valuable resource for researchers, healthcare providers, and individuals seeking information on genetic testing for Factor XIII deficiency and related conditions. It offers access to scientific articles, references, and additional resources related to the F13A1 gene and its functions in clot formation.
Furthermore, the GTR provides links to other databases such as OMIM and PubMed, which offer more in-depth information on genetic diseases, disorders, and conditions. These databases contain a wealth of information on Factor XIII deficiency, its subunits, related genes, and their functions in blood clotting.
By listing the tests and associated information in the GTR, healthcare providers can easily access the necessary resources to diagnose and manage Factor XIII deficiency. The GTR serves as a comprehensive catalog that consolidates information from various sources, enabling efficient access to relevant genetic testing information.
Overall, the GTR plays a crucial role in facilitating genetic testing for Factor XIII deficiency and other genetic diseases. It serves as a centralized hub of information, providing access to resources, cataloging tests, and contributing to the advancement of scientific knowledge in the field of genetics.
Scientific Articles on PubMed
PubMed is a valuable resource for finding scientific articles related to the F13A1 gene and its functions. Below are some articles listed on PubMed that provide information on diseases, genetic variants, and other related topics:
Diseases and Disorders
- F13A1 gene deficiency: This article explores the deficiency of the F13A1 gene and its impact on blood clotting disorders.
- OMIM database: OMIM is a comprehensive catalog of human genes and genetic disorders. This article discusses the F13A1 gene and related diseases listed in the OMIM database.
Genetic Variants and Testing
- Genetic testing for F13A1 gene changes: This article provides information on genetic tests available for detecting changes in the F13A1 gene.
- Testing for F13A1 gene mutations: This article discusses the different tests used to identify mutations in the F13A1 gene and their implications on health.
Functions and Factors
- Functions of F13A1 gene subunits: This article explores the specific functions of subunits of the F13A1 gene and their role in blood clotting.
- Factor XIIIA and related factors: This article discusses Factor XIII and related factors involved in blood clotting processes.
Additional Resources
- F13A1 gene registry: This article provides information on a registry for individuals with F13A1 gene-related disorders.
- PubMed references for F13A1 gene: This article lists additional references available on PubMed for further study of the F13A1 gene.
In conclusion, PubMed offers a wide range of scientific articles on the F13A1 gene and its related diseases, functions, and testing. These resources can provide valuable information for researchers, healthcare professionals, and individuals interested in studying or understanding the F13A1 gene.
Catalog of Genes and Diseases from OMIM
In the context of the F13A1 gene, OMIM (Online Mendelian Inheritance in Man) serves as a valuable resource for information on genes and diseases. OMIM is a registry of genes and genetic disorders, providing detailed information on the functions and other common characteristics of different genes.
F13A1 is one of the genes listed in OMIM, which is associated with various diseases. This gene plays a crucial role in blood clotting. Deficiencies in the F13A1 gene can lead to health changes and diseases related to clotting in the bloodstream.
Factor XIIIA, also known as factor XIII, is the protein encoded by the F13A1 gene. This protein is part of the clotting factor, which helps stabilize blood clots. Genetic variations in the F13A1 gene can affect the function of factor XIII and its related factors.
OMIM provides references to related articles and studies on the F13A1 gene and its associated conditions. These references are often sourced from PubMed, a database of scientific articles. This information can be useful for further research and understanding of F13A1-related diseases.
OMIM also offers additional genetic databases for testing and information on other genes related to factor XIII deficiency and related conditions. These resources can assist in the diagnosis and management of genetic disorders.
In conclusion, OMIM serves as a comprehensive catalog of genes and diseases, including the F13A1 gene and its associated conditions. It provides valuable information on the functions of genes, related diseases, and references to scientific articles for further exploration.
Gene and Variant Databases
Gene and variant databases are valuable resources for researchers, physicians, and patients interested in the F13A1 gene. These databases provide information on the gene, its variants, and related diseases, helping to advance our understanding of genetic factors involved in various disorders.
One of the most commonly used gene databases is PubMed, which hosts a vast collection of scientific articles. Researchers can find articles related to the F13A1 gene and its role in various diseases and health conditions. By exploring articles indexed in PubMed, scientists can gain valuable insights into the function and significance of this gene.
Variant databases, on the other hand, focus on specific changes or mutations within the F13A1 gene. These changes can lead to deficiencies or abnormalities in the FXIII-A subunit, resulting in clotting disorders. The F13A1 gene is also known as the FXIII-A gene, as it codes for the FXIII-A subunit of clotting Factor XIII.
Some of the variant databases for the F13A1 gene include:
- The Online Mendelian Inheritance in Man (OMIM) catalog provides comprehensive information on genetic conditions and related genes, including F13A1.
- The Clotting Factor XIII Variant Database is a registry of mutations and sequence changes in F13A1. It is a part of the International Society of Thrombosis and Hemostasis (ISTH) genetic testing registry.
- The NCBI Gene database provides information on the F13A1 gene, including its genetic location, function, and related disorders.
In addition to these databases, further resources can be found through references in scientific articles and publications. These resources provide additional information on F13A1-related diseases, genetic tests, and other factors that may be relevant to understanding the gene’s role in various disorders.
By utilizing gene and variant databases, researchers and healthcare professionals can access a wealth of genetic information that can contribute to improved diagnosis and treatment of diseases related to the F13A1 gene.
References
The following resources provide additional information on the F13A1 gene and related topics. Some articles may require a subscription or purchase to access the full text.
- OMIM – A comprehensive catalog of human genes and genetic disorders. The entry for F13A1 provides information on the gene, its subunits, functions, and related conditions. Available at: https://www.omim.org/entry/134570
- PubMed – A database of scientific articles. Searching for “F13A1” or related keywords will provide a list of articles on this gene and its role in various diseases and conditions. Available at: https://pubmed.ncbi.nlm.nih.gov/
- F13A1 Gene Testing Registry – This registry lists testing laboratories and available tests for changes in the F13A1 gene. Available at: https://www.ncbi.nlm.nih.gov/gtr/genes/2162/
- PubMed Central – A free full-text archive of biomedical and life sciences journal articles. Searching for “F13A1” or related keywords will provide access to additional articles on this gene and its functions. Available at: https://www.ncbi.nlm.nih.gov/pmc/
Additional information on F13A1 gene testing, related genes, and genetic disorders can be found in various scientific databases and resources. It is recommended to consult these sources for more specific and detailed information.
| Gene Name | Common Name | OMIM ID |
|---|---|---|
| F13B | Coagulation Factor XIII B Chain | 134580 |
| F13A1 | Coagulation Factor XIII A Chain | 134570 |
| F13 | Coagulation Factor XIII | 134570, 134580 |
| F12 | Coagulation Factor XII | 134570 |
| F11 | Coagulation Factor XI | 134570 |