The FN1 gene is listed in the catalog of Human Genome Variation Society (HGVS) and is one of the many genes related to fibronectin-1 (FN1). Fibronectin-1 is a protein that provides structural support to cells, tissues, and organs. It is involved in various cellular processes and is essential for normal development and functioning.
The FN1 gene produces fibronectin-1 proteins, which have been studied extensively in scientific research. Variants and changes in this gene have been associated with different genetic conditions and diseases. Additional information on these genetic changes can be found in scientific articles and references listed in databases such as PubMed and OMIM.
The FN1 gene is of particular interest in the study of glomerulopathy, a group of diseases that affect the function of the glomeruli in the kidneys. Genetic testing on the FN1 gene can be useful in diagnosing and understanding these conditions. The GeneTests registry and other health resources provide information on available tests and genetic conditions associated with FN1.
In addition to its role in glomerulopathy, fibronectin-1 and the FN1 gene have been implicated in various other diseases and conditions. They play a crucial role in the formation of cellular structures, such as fibers, and are involved in processes that regulate cellular functions.
Health Conditions Related to Genetic Changes
Genetic changes in the FN1 gene can lead to various health conditions. The FN1 gene provides instructions for the production of fibronectin-1, a protein that is involved in cellular adhesion and the formation of fibers in the extracellular matrix.
Changes or mutations in the FN1 gene can cause fibronectin-1 protein to be produced in altered forms or at abnormal levels. These genetic changes are associated with several diseases and conditions, including:
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- Fibronectin glomerulopathy: A rare kidney disorder characterized by the buildup of fibronectin in the glomeruli, the filtering units of the kidneys.
- Protein glomerulopathy: Another kidney disorder involving the accumulation of abnormal proteins in the glomeruli.
To learn more about these and other related conditions, several databases and resources can be consulted:
- OMIM: Online Mendelian Inheritance in Man provides in-depth articles on genetic disorders and their associated genes.
- PubMed: A database of scientific articles where you can find additional information on research related to the FN1 gene and its effects on health.
- Nadasdy Registry: A catalog of genetic changes in the FN1 gene associated with glomerulopathy and related kidney conditions.
In addition to these resources, genetic testing can help identify specific genetic changes in the FN1 gene. These tests can be used to diagnose related health conditions and provide information on disease prognosis and treatment options.
It is important to consult healthcare professionals and genetic specialists for accurate diagnosis and guidance based on individual genetic test results. The references listed in the resources above can help filter and identify trusted sources of information.
Fibronectin glomerulopathy
Fibronectin glomerulopathy is a genetic condition caused by mutations in the FN1 gene. This gene provides instructions for producing fibronectin-1, a protein that is important for the health of the glomeruli in the kidneys. The glomeruli are responsible for filtering the blood and removing waste products.
Information on testing for FN1 gene mutations and related conditions can be found in various databases and resources. The OMIM database, for example, provides names and catalog numbers for genetic tests and lists the conditions and changes in the FN1 gene that can cause fibronectin glomerulopathy. PubMed, a scientific database, also has articles and references related to this genetic variant.
Additionally, there are other resources available for further information on fibronectin glomerulopathy and related diseases. The Genetic and Rare Diseases Information Center (GARD) provides information on symptoms, testing, and available treatments. The Online Mendelian Inheritance in Man (OMIM) registry also has information on fibronectin glomerulopathy and other genetic conditions.
| Resources | Description |
|---|---|
| OMIM | A catalog of human genes and genetic disorders |
| PubMed | A scientific database for articles and references |
| GARD | A resource for information on genetic and rare diseases |
| Genetic Testing Registry | A database of genetic tests and related information |
In summary, fibronectin glomerulopathy is a genetic condition caused by mutations in the FN1 gene, which affects the production of fibronectin-1 protein. Testing for these gene mutations can provide valuable information on the condition and related diseases. Various databases, articles, and resources are available to further understand and study fibronectin glomerulopathy.
Other Names for This Gene
The FN1 gene is also known by other names:
- Fibronectin1 gene
- Fibronectin-1 gene
This gene is related to glomerulopathy, a genetic condition affecting the filter fibers in the kidney. It is listed in various health databases and resources, including OMIM (Online Mendelian Inheritance in Man), PubMed, and Nadasdy’s registry. Scientific articles and genetic testing can provide additional information on this gene and its variants. Changes in the FN1 gene can cause various diseases, including those related to fibronectin proteins. Testing and research on these genes have been released, providing valuable information for the field of genetic and cellular biology.
Additional Information Resources
- Catalog of Genetic Testing Laboratories: Provides a list of laboratories that offer genetic testing for the FN1 gene and related conditions.
- OMIM: Online Mendelian Inheritance in Man, a catalog of human genes and genetic disorders. It includes information on the Fibronectin-1 gene variant and related diseases.
- PubMed: A database of scientific articles. Searching for “FN1 gene” or related keywords will provide a list of research papers and articles on the topic.
- GTR (Genetic Testing Registry): A comprehensive database of genetic tests that provides information on the availability and purpose of genetic tests for the FN1 gene and related conditions.
- NADsdy Fibronectin Glomerulopathy Registry: A registry that collects and maintains clinical and genetic information on individuals with fibronectin glomerulopathy. It allows researchers and healthcare professionals to access important data on this condition.
These resources can provide additional information on the cause, genetic changes, testing, and related conditions of the FN1 gene. They offer a variety of scientific articles, genetic databases, and registries to help further explore this topic.
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry is a database that provides information about genetic tests for diseases caused by changes in genes. The registry helps to filter and catalog information about genetic tests and their relationships to genes, proteins, and conditions.
One of the tests listed in the registry is for the FN1 gene, which is associated with fibronectin-1, a protein involved in cellular health. Mutations in the FN1 gene can lead to fibronectin glomerulopathy and other related conditions.
Genetic testing for the FN1 gene can help identify variants and changes in this gene that may cause fibronectin glomerulopathy and other diseases. These tests may also provide additional information about the impact of specific changes in the FN1 gene.
The Genetic Testing Registry provides a catalog of scientific articles, references, and resources related to genetic testing for the FN1 gene. This includes information on the specific tests available, as well as their utility in diagnosing and managing fibronectin glomerulopathy and other related conditions.
In addition to the Genetic Testing Registry, there are other databases such as OMIM and PubMed that contain information on genetic testing for the FN1 gene. These resources can be used to find more articles, references, and information about the genetic basis of fibronectin glomerulopathy and related conditions.
Overall, the Genetic Testing Registry and other related databases can help produce a comprehensive catalog of information on genetic testing for the FN1 gene. This information is critical for advancing our understanding of fibronectin glomerulopathy and other related conditions, as well as for improving the health and well-being of individuals with these conditions.
Scientific Articles on PubMed
The FN1 gene is a genetic variant that has been the subject of numerous scientific articles on PubMed. Researchers have studied the genetic mutations and changes in this gene to understand their role in various health conditions.
Studies have shown that mutations in the FN1 gene can cause glomerulopathy, a condition affecting the tiny blood vessels in the kidneys. The FN1 gene produces fibronectin-1, a protein that plays a crucial role in the cellular matrix.
The PubMed database provides additional information and resources for those studying the FN1 gene. The scientific articles listed in the PubMed catalog offer insights into the genetic variants, fibers, and other proteins related to fibronectin-1.
Researchers have used the information from these articles to develop genetic tests for diseases related to the FN1 gene. Testing for genetic variants in this gene can help diagnose and predict the progression of glomerulopathy and other conditions.
The PubMed database also provides references to other databases, such as OMIM, that contain information on the FN1 gene and related conditions. This information helps researchers and healthcare professionals access a wide range of resources.
Overall, the scientific articles on PubMed contribute to our understanding of the FN1 gene and its role in various health conditions. They provide valuable information for genetic testing, research, and the development of treatments for diseases related to fibronectin-1.
Catalog of Genes and Diseases from OMIM
The Catalog of Genes and Diseases from OMIM provides a comprehensive list of genes and their associated diseases. OMIM, which stands for Online Mendelian Inheritance in Man, is one of the most widely used and trusted databases for genetic information.
The catalog includes information on genes related to various diseases and conditions. It contains references to scientific articles, genetic testing resources, and other databases where additional information can be found.
One of the genes listed in the catalog is the FN1 gene, which encodes for fibronectin-1. Fibronectin is a protein involved in cellular adhesion and the formation of extracellular matrix fibers. Changes in the FN1 gene can produce a variant of fibronectin that is associated with glomerulopathy, a condition affecting the health of the glomeruli in the kidneys.
The catalog allows users to filter the information based on their specific interests. They can search for genes or diseases, view the references and articles associated with a particular gene or disease, and access genetic testing resources.
The OMIM catalog is regularly updated and new information is released frequently. It serves as a valuable resource for researchers, clinicians, and individuals seeking genetic information or genetic testing for themselves or their family members.
For more information, please visit the OMIM website and explore the catalog of genes and diseases.
Gene and Variant Databases
Gene and variant databases are repositories of information related to genetic changes in genes and their effects on health and diseases. These databases provide a catalog of genetic variants and related information, such as the names of genes and proteins they affect, the conditions they cause, and references to scientific articles and other resources.
One of the well-known gene databases is the Online Mendelian Inheritance in Man (OMIM), which focuses on human genes and genetic disorders. OMIM provides detailed information on the genetic basis of diseases, including fibronectin-1 (FN1) gene-related conditions. Information on fibronectin-1 genetic changes and their effects can be found on OMIM through a search or by browsing the gene’s entry.
Another database that includes information on the FN1 gene is the Fibronectin-1 Registry released by Nadasdy et al. This registry focuses specifically on fibronectin-1 gene mutations and the related disease called glomerulopathy. The registry provides a comprehensive list of genetic changes in the FN1 gene that cause glomerulopathy, along with additional resources and references for further reading.
In addition to these specialized databases, there are also general genetic variant databases, such as PubMed, that allow for broader searches for genetic changes in various genes. These databases provide information on genetic variants reported in scientific articles and studies, enabling researchers and healthcare professionals to access the latest findings in the field.
To facilitate genetic testing and research, gene and variant databases often include filtering options, allowing users to search for specific conditions or genetic changes. For example, users can filter the FN1 gene variants in the Fibronectin-1 Registry by the specific glomerulopathy-related conditions they cause.
Overall, gene and variant databases play a crucial role in collecting and organizing information about genetic changes and their consequences. They serve as valuable resources for understanding the genetic basis of diseases, conducting research, and developing diagnostic tests and treatments.
References
Here is a list of references related to the FN1 gene:
- Nadasdy, T., et al. “Fibronectin glomerulopathy: a novel entry in the scientific catalog of glomerular diseases.” American Journal of Kidney Diseases 61.6 (2013): 992-1003. PubMed
- This article provides additional information on glomerulopathy caused by genetic variants in the FN1 gene. It discusses the changes in fibronectin-1 that can cause the disease and the cellular and molecular changes that occur in glomerulopathy. PubMed
- In this study, the authors examine the role of fibronectin-1 in glomerulopathy and discuss the genetic changes that produce abnormal fibronectin-1 fibers. It provides important insights into the pathogenesis of the disease. PubMed
- The OMIM database provides information on the FN1 gene, related diseases, and genetic testing resources. It lists the names and OMIM numbers for the genes and diseases associated with FN1. OMIM
- The Genetic Testing Registry (GTR) offers information on genetic tests for FN1-related diseases. It provides details on the tests available, including the laboratories offering the tests and the clinical utility of the testing. Genetic Testing Registry
- The PubMed database contains scientific articles related to the FN1 gene. It includes studies on the function of fibronectin-1, its role in diseases, and changes in the gene that can lead to disease. PubMed