Guselkumab Injection

Guselkumab injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults whose psoriasis is too severe to be treated by topical medications alone. It is also used alone or in combination with other medications to treat psoriatic arthritis (a condition that causes joint pain and swelling and scales on the skin) in adults. Guselkumab injection is in a class of medications called monoclonal antibodies. It works by stopping the action of certain cells in the body that cause the symptoms of psoriasis.

🔔 How should this medicine be used?

Guselkumab injection comes as a solution (liquid) in a prefilled syringe and a prefilled automatic injection device to inject subcutaneously (under the skin). It is usually injected once every 4 weeks for the first two doses and then continued once every 8 weeks. Use guselkumab injection exactly as directed. Do not inject more or less of it or inject it more often than prescribed by your doctor.

You will receive your first dose of guselkumab injection in your doctor’s office. After that, your doctor may allow you to inject guselkumab yourself or have a caregiver give the injections. Ask your doctor or pharmacist to show you or the person who will be giving the injections how to inject guselkumab. Before you use guselkumab injection yourself the first time, read the written instructions that come with it.

Use each syringe or automatic injection device only once and inject all the solution in the syringe. Discard the used syringe or device even if there is still some medication left in it. Dispose of used syringes or devices in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.

Remove the prefilled syringe or automatic injection device from the refrigerator, place the syringe on a flat surface without removing the needle cover or device cap, and allow it warm to room temperature for 30 minutes before you are ready to inject the medication. Do not try to warm the medication by heating it in a microwave, placing it in hot water, leaving it in sunlight, or through any other method.

Do not shake a prefilled syringe or automatic injection device that contains guselkumab. Do not use guselkumab prefilled syringe if it is dropped; it has glass parts and should be handled carefully.

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Always look at guselkumab solution before injecting it. Check that the expiration date has not passed and that the liquid is clear and colorless to light yellow solution. The liquid may contain a few visible particles. Do not use the prefilled syringe or device if it is damaged, expired, frozen, or if the liquid is cloudy, discolored, or contains large particles.

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Inject guselkumab injection within 5 minutes of removing the needle cover or device cap. Do not replace the needle cover or device cap as this can damage the needle or cause injury. Do not use an automatic injection device that has been dropped after removal of the device cap.

You can inject guselkumab injection anywhere on the front of your thighs (upper leg), back of upper outer arms, or abdomen (stomach) except your navel and the area 2 inches (5 centimeters) around it. To reduce the chances of soreness or redness, use a different site for each injection. Do not inject into an area where the skin is tender, bruised, red, hard.