Idiopathic Inflammatory Myopathy (IIM) is a rare group of inflammatory muscle diseases that affect the body’s muscles, causing weakness and difficulty in daily activities. The exact causes of IIM are not well understood, but it is believed to have a genetic component.

There are several genes associated with IIM, and research is still ongoing to learn more about the genetic basis of this condition. The OMIM database provides information about these genes and their associated inheritance patterns. Additional resources can be found in scientific articles and research studies available on PubMed.

The immune system is also thought to play a role in the development of IIM. Inflammatory myopathy occurs when the immune system mistakenly attacks the body’s own muscles, resulting in inflammation and damage. However, the exact mechanisms behind this immune response are not yet fully understood.

Diagnosing IIM can be challenging, as the symptoms can vary widely from person to person. The frequency of this condition is rare, making it difficult to study and gather information. ClinicalTrials.gov can provide information on ongoing studies and clinical trials related to IIM.

Support and advocacy groups can provide additional resources for patients and families affected by IIM. They can offer support and information about genetic testing, treatment options, and research advancements. The Myositis Center is one such organization that provides comprehensive care and support for those living with IIM.

In conclusion, idiopathic inflammatory myopathy is a rare group of inflammatory muscle diseases that can occur in individuals of any age. With ongoing research and study, we hope to learn more about the genetic and immune factors that contribute to the development and progression of IIM, as well as find more effective treatments for this challenging condition.

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Frequency

Idiopathic inflammatory myopathy is a rare group of diseases characterized by weakness and inflammation of the muscles. The exact frequency of this condition is difficult to determine as it is rare and studies on its prevalence are limited.

The Center for Genetic Testing and Research (CGTR) is a center dedicated to learning more about rare genetic conditions and provides resources for patients and healthcare providers. They gather scientific information from various sources such as OMIM, PubMed, and other articles to catalog genes associated with different diseases, including idiopathic inflammatory myopathy.

Inheritance of idiopathic inflammatory myopathy can be genetic, however, it can also occur sporadically without a family history. This adds to the difficulty in determining the exact frequency of the condition.

Additional resources for information on idiopathic inflammatory myopathy and other related diseases can be found from advocacy groups and support centers that provide support and information to patients and their families.

ClinicalTrials.gov is a valuable resource for ongoing research and clinical trials. It provides information on current studies related to idiopathic inflammatory myopathy and other similar conditions.

In summary, due to the rarity of idiopathic inflammatory myopathy and the difficulties associated with its genetic inheritance, determining its exact frequency is challenging. However, there are several resources available for learning more about the condition and ongoing research efforts.

Causes

The exact causes of idiopathic inflammatory myopathy (IIM) are still unknown. However, several factors have been associated with the development of this rare condition.

Genetic factors are believed to play a role in the development of IIM. Studies have shown that certain proteins involved in immune responses may be abnormal in individuals with IIM, suggesting a genetic component. However, the specific genes involved in IIM inheritance are still being researched.

Inflammatory myopathies can occur in individuals with a family history of the condition, indicating a potential genetic link. However, the frequency of inheritance among family members is relatively rare.

Other causes of IIM may include immune abnormalities, although the precise mechanisms are not fully understood. Additionally, environmental factors, such as infections or exposure to certain drugs, may trigger the development of IIM in certain individuals.

More resources and information on IIM causes can be found through various research and advocacy organizations, such as the Myositis Association and the Myositis Research Catalog. These resources provide information on genetic testing, clinical trials, and additional support for individuals with IIM and other related myopathies.

References:

• Genetic and Rare Diseases Information Center. (2021). Idiopathic Inflammatory Myopathy.
• OMIM – Online Mendelian Inheritance in Man. (2021). Inflammatory Myopathy with Abundant Macrophages 2; IMA2.
• PubMed. (2021). Idiopathic Inflammatory Myopathies.
• ClinicalTrials.gov. (2021). Idiopathic Inflammatory Myopathies.

Learn more about the genes associated with Idiopathic inflammatory myopathy

Idiopathic inflammatory myopathy is a difficult condition to diagnose and manage. There are several genes associated with this rare group of diseases. Genetic testing can provide additional information for the patient and help in developing a treatment plan.

Here are some resources where you can learn more about the genes associated with idiopathic inflammatory myopathy:

• OMIM (Online Mendelian Inheritance in Man) catalog: OMIM is a comprehensive catalog of human genes and genetic disorders. It provides detailed information on the genes associated with idiopathic inflammatory myopathy.
• ClinicalTrials.gov: ClinicalTrials.gov is a database of clinical studies being conducted around the world. It can provide information on ongoing research studies related to the genetic causes of idiopathic inflammatory myopathy.
• PubMed: PubMed is a database of scientific articles. It can be used to search for research papers and articles about the genetic basis of idiopathic inflammatory myopathy.

Inflammatory myopathies occur when the body’s immune system mistakenly attacks the muscles. The exact causes of idiopathic inflammatory myopathy are not fully understood, and genetic factors contribute to the development of the condition.

Genetic testing can help identify specific genes and proteins associated with idiopathic inflammatory myopathy, providing valuable information for patient management and potential targeted therapies.

Support and advocacy groups for patients with idiopathic inflammatory myopathy may also have more information on the genetic aspects of the condition, as well as references to scientific articles and studies.

Overall, learning more about the genetic factors contributing to idiopathic inflammatory myopathy can provide important insights into the condition’s inheritance patterns, frequency, and potential treatment options.

Inheritance

The inheritance pattern of idiopathic inflammatory myopathy (IIM) is not well understood. IIM refers to a group of rare diseases that cause inflammation and weakness in the muscles. There are several different types of IIM, each with its own set of characteristics and clinical features.

Some forms of IIM have been found to have a genetic component, suggesting that certain genes may play a role in the development of the condition. However, the exact genes involved and the inheritance patterns are not yet fully understood. It is believed that both genetic and environmental factors may contribute to the development of IIM.

Research studies have identified several genes that may be associated with IIM. These genes are involved in the immune system and are responsible for regulating inflammation in the body. Mutations in these genes may lead to an overactive immune response and the inflammatory symptoms seen in IIM patients.

Genetic testing can be done to identify mutations in these genes, but it is often difficult to determine the significance of these mutations in individual patients. Additionally, the frequency of these mutations in the general population is not well known, making it difficult to assess their role in the development of IIM.

For more information about the genetic causes of IIM, there are resources available such as the Online Mendelian Inheritance in Man (OMIM) catalog. This catalog provides information on genes and genetic conditions, including IIM. Other articles and studies on IIM can also be found on websites such as ClinicalTrials.gov.

It is important for patients with IIM and their families to have access to genetic testing and counseling to learn more about the inheritance patterns and genetic risks associated with this condition. In some cases, additional support and advocacy groups may be available to provide information and resources for patients and their families.

Resources	Links
ClinicalTrials.gov	https://www.clinicaltrials.gov
Online Mendelian Inheritance in Man (OMIM)	https://omim.org

Other Names for This Condition

Idiopathic inflammatory myopathy is a rare group of diseases characterized by weakness and inflammation of the body’s muscles. It is also known by several other names:

• Idiopathic myositis
• Inflammatory myopathy
• Myositis
• Idiopathic myopathy

These names are used interchangeably and refer to the same condition, which is characterized by inflammation in the muscles, causing weakness and associated symptoms.

It is important to note that while the exact causes of idiopathic inflammatory myopathy are unknown, research suggests that it may have a genetic component. Genetic studies have identified several genes and proteins that may be involved in the development of this condition. However, the inheritance pattern and frequency of these genetic factors are still being studied.

Information on genetic testing and inheritance patterns for idiopathic inflammatory myopathy can be found in scientific articles, as well as resources such as OMIM (Online Mendelian Inheritance in Man) and the Genetic and Rare Diseases Information Center. These resources provide additional information about the genetic aspects of this condition.

In addition to genetic research, studies are also being conducted to understand the immune and inflammatory processes that occur in idiopathic inflammatory myopathy. Clinical trials.gov is a valuable resource for information on ongoing clinical trials investigating new treatments for this condition.

Support and advocacy groups, such as the Myositis Association, provide resources and information for patients and families affected by idiopathic inflammatory myopathy. These groups offer support, educational materials, and connections to clinical trials and treatment options.

References and articles about idiopathic inflammatory myopathy can be found in scientific journals, as well as databases like PubMed. These sources provide in-depth information about the clinical features, diagnosis, and management of this condition.

Additional Information Resources

When it comes to rare diseases like idiopathic inflammatory myopathy (IIM), it can be difficult to find comprehensive and reliable information. However, there are several resources available to support patients, families, and healthcare professionals in learning more about this condition. The following resources are particularly helpful:

• National Institutes of Health (NIH) – The NIH is a scientific research organization that supports the development of studies and clinical trials for various diseases. You can find more information about IIM and related myopathies on their website.
• ClinicalTrials.gov – This online database provides information about clinical trials in progress. You can search for ongoing studies related to IIM by using keywords like “idiopathic inflammatory myopathy” or “myositis”.
• Online Mendelian Inheritance in Man (OMIM) – OMIM is a comprehensive catalog of human genes and genetic disorders. It provides detailed information about the genes associated with IIM, inheritance patterns, and more.
• PubMed – PubMed is a database of scientific articles. You can find a wealth of information about IIM, including studies, case reports, and reviews, by searching for keywords like “idiopathic inflammatory myopathy” or “myositis”.
• Patient support groups and advocacy organizations – Connecting with others who have IIM or other related diseases can provide valuable support and information. These groups can also help you find local resources and access to specialists who are knowledgeable about IIM.
• Genetic testing centers – If you suspect that your IIM may have a genetic component, seeking genetic testing can provide additional information about the underlying causes. Genetic testing centers can help determine if there are specific gene mutations or variations associated with your condition.

Remember that everyone’s experience with IIM may be different, and it’s important to consult with your healthcare provider for personalized advice and guidance.

Genetic Testing Information

Genetic testing plays an important role in the diagnosis and management of idiopathic inflammatory myopathy (IIM). It provides valuable information about the genetic causes of this condition, helping both patients and healthcare providers understand the underlying mechanisms and develop appropriate treatment plans.

IIM is a group of rare diseases characterized by inflammation and weakness in the body’s muscles. While the exact cause of IIM is unknown, genetic factors are thought to play a role in the development of the condition. By identifying specific genes associated with IIM, genetic testing can help determine the inheritance patterns and provide insights into disease progression, response to treatment, and prognosis.

There are several genes that have been identified in association with IIM, including the HLA genes and several other genes related to the body’s immune system. Genetic testing can help identify mutations or variations in these genes, which can aid in the diagnosis and management of the condition.

Genetic testing can be challenging for IIM patients, as the frequency of genetic mutations can be low and the genetic causes of the condition are still not fully understood. However, advancements in genetic research and technology are making it increasingly possible to identify these genetic factors.

There are resources available to support patients and healthcare providers in accessing genetic testing for IIM. OMIM (Online Mendelian Inheritance in Man) provides a comprehensive catalog of genes and genetic disorders, including IIM. The Myositis Information Center and advocacy groups such as Myositis Support and Understanding offer additional information and support for patients and their families.

ClinicalTrials.gov is also a useful resource for information on ongoing genetic studies and clinical trials related to IIM. These studies can provide valuable insights into the genetic causes of IIM and may offer opportunities for patients to participate in research and access cutting-edge treatments.

It is important for patients and healthcare providers to stay informed about the latest research and advancements in genetic testing for IIM. Scientific articles and publications, as well as references from PubMed, can provide up-to-date information on genetics and IIM.

In conclusion, genetic testing plays a crucial role in the diagnosis, management, and understanding of idiopathic inflammatory myopathy. By identifying genetic factors associated with IIM, it can help determine the inheritance patterns, provide insights into disease progression, and guide treatment decisions. However, due to the rarity of the condition and the complexity of genetic factors, accessing genetic testing and interpreting the results can be challenging. Patients and healthcare providers can rely on various resources and organizations for support and information on genetic testing for IIM.

Genetic and Rare Diseases Information Center

The Genetic and Rare Diseases Information Center (GARD) is a valuable resource for patients, families, healthcare providers, and researchers interested in learning more about idiopathic inflammatory myopathy (IIM) and other rare genetic conditions. GARD is an authoritative and comprehensive source of information that provides easy access to a wide range of resources on rare diseases.

GARD offers information on the genetic causes, clinical features, inheritance patterns, and frequency of rare diseases, including IIM. GARD maintains a catalog of genes associated with IIM and updates this information as new scientific discoveries are made. Patients and their families can use this database to learn more about the genes that can cause IIM and understand how these genes may be inherited within families.

GARD also provides information on the clinical aspects of IIM, including symptoms, diagnosis, and treatment options. Patients can find articles from PubMed and additional reputable sources to learn more about the latest scientific research on IIM. GARD also offers information on ongoing clinical trials for IIM patients through ClinicalTrials.gov, allowing patients to stay updated on the latest treatment options and research opportunities.

In addition to providing information, GARD advocates for rare disease patients and their families by connecting them with support groups and advocacy organizations that specialize in IIM and related conditions. These organizations can provide valuable support, resources, and assistance to patients and their families as they navigate the challenges of living with a rare and often difficult to diagnose condition like IIM.

Overall, the Genetic and Rare Diseases Information Center (GARD) is a comprehensive and reliable resource for individuals and families affected by idiopathic inflammatory myopathy. It offers a wealth of information on the genetic and clinical aspects of the condition, as well as additional resources for support, research, and advocacy. GARD is dedicated to improving the lives of rare disease patients by providing accurate and up-to-date information on IIM and other rare diseases.

Patient Support and Advocacy Resources

If you or someone you know has been diagnosed with idiopathic inflammatory myopathies (IIM), finding the right support and advocacy resources can make a significant difference in managing the condition. These resources can provide valuable information, guidance, and emotional support to patients and their families. Here are some organizations and websites that offer patient support and advocacy for those with IIM:

• Myositis Support and Understanding (MSU): MSU is a nonprofit organization dedicated to providing support, education, and advocacy for individuals affected by myositis. They offer a variety of resources, including an online support group, educational materials, and a patient registry.
• Myositis Association (TMA): TMA is another organization that provides support and resources for individuals with myopathies, including those with IIM. They offer information on diagnosis and treatment options, as well as opportunities to participate in research studies and clinical trials.
• The Genetic and Rare Diseases Information Center (GARD): GARD provides information about rare genetic diseases, including idiopathic inflammatory myopathies. They offer resources on symptoms, causes, inheritance patterns, and available treatments. They also have a database of scientific articles, clinical trials, and other references related to IIM.

It is important to note that the exact causes of idiopathic inflammatory myopathies are still not fully understood. However, research suggests that they may be immune-mediated conditions, where the immune system mistakenly attacks the body’s own muscle tissues. Scientists believe that a combination of genetic and environmental factors may play a role in developing IIM.

Genetic testing can also provide additional information about the association between certain genes and the development of idiopathic inflammatory myopathies. OMIM (Online Mendelian Inheritance in Man) is a valuable resource for learning about the inheritance patterns and genetic mutations associated with different forms of IIM.

In addition to these resources, clinicaltrials.gov is a website that provides information about ongoing clinical trials for idiopathic inflammatory myopathies. This can be a helpful tool for finding potential treatments and opportunities to participate in research studies.

Overall, patient support and advocacy groups can offer a wealth of information and support for individuals with idiopathic inflammatory myopathies and their families. By connecting with these resources, patients can learn more about their condition, find emotional support, and participate in research studies that may contribute to advancements in the understanding and treatment of these rare myopathies.

Research Studies from ClinicalTrials.gov

Inflammatory myopathy refers to a group of rare genetic diseases characterized by weakness and inflammation of the muscles. The exact causes of these myopathies are not fully understood, however, research studies from ClinicalTrials.gov provide valuable scientific information to learn more about the genetic and immune factors associated with this condition.

ClinicalTrials.gov is a comprehensive catalog of research studies conducted worldwide. It serves as a valuable resource for patients, advocacy groups, and healthcare professionals to find information about ongoing studies, testing new treatments, and supporting the development of new therapies.

Research studies listed on ClinicalTrials.gov often focus on the identification of genetic and immune-related factors that contribute to the inflammatory myopathy. The genes and proteins involved in the development of this condition play a crucial role in understanding the inheritance patterns, frequency, and clinical manifestations of different myopathies.

By exploring the research studies listed on ClinicalTrials.gov, scientists and clinicians can gain insight into the genetic basis of the myopathy, identify additional genes and proteins associated with the condition, and develop targeted therapies for patients.

This scientific information can be used by advocacy groups and healthcare professionals to support patients and their families by providing accurate and up-to-date information about the genetic causes of the myopathy, available clinical trials and resources for additional support.

Some of the research studies registered on ClinicalTrials.gov may involve testing new treatments or interventions for patients with inflammatory myopathy. These studies aim to evaluate the effectiveness and safety of novel therapies in improving muscle strength and function, reducing inflammation, and enhancing the overall quality of life for patients.

In conclusion, ClinicalTrials.gov provides a valuable platform for researchers, patients, and advocacy groups to access scientific information about the genetic and immune factors associated with inflammatory myopathy. By utilizing the resources and information available on ClinicalTrials.gov, we have the opportunity to advance our understanding of this rare condition and develop improved therapies for patients.

Catalog of Genes and Diseases from OMIM

The Online Mendelian Inheritance in Man (OMIM) is a comprehensive catalogue of genes and genetic diseases. It provides valuable information on various medical conditions, including idiopathic inflammatory myopathy.

Idiopathic inflammatory myopathy is a group of rare diseases that affect the body’s immune system, causing inflammation and damage to muscles. The exact cause of these diseases is unknown, hence the term “idiopathic”. However, genetic studies have shown that several genes and proteins are associated with idiopathic inflammatory myopathy.

OMIM provides information on the genetic causes of idiopathic inflammatory myopathy and other related myopathies. It also offers resources for patient advocacy groups, clinical trials, and research centers developing treatments for these diseases.

OMIM’s catalog includes information on the inheritance patterns, clinical features, and additional references for each genetic condition. It also provides frequency data and links to scientific articles and research papers on the topic.

Genetic testing is often necessary to diagnose idiopathic inflammatory myopathy and identify the specific gene mutations associated with the condition. OMIM can help healthcare providers and patients learn more about the genetic testing process and interpret the results.

In summary, OMIM is a valuable resource for understanding the genetic causes of idiopathic inflammatory myopathy and other myopathies. It provides information, advocacy support, and access to clinical trials for patients and their families.

• OMIM catalog of genes and diseases
• Information on idiopathic inflammatory myopathy
• Genetic studies and inheritance patterns
• Clinical trials and research centers
• Patient advocacy and support
• Frequency and rarity of myopathies
• Links to scientific articles and publications
• Genetic testing and interpretation

For more information on idiopathic inflammatory myopathy and related genetic diseases, please visit the OMIM website or refer to the references listed on clinicaltrialsgov and PubMed.

Scientific Articles on PubMed

This section provides information about scientific articles related to idiopathic inflammatory myopathy (IIM) found on PubMed. PubMed is a well-known and widely used resource for accessing medical and scientific literature. It is a centralized database that catalogues articles from various academic journals and research centers.

IIM is a rare condition characterized by inflammation and weakness in the patient’s muscles. It can affect people of all ages, including children. The exact cause of IIM is currently unknown, and hence it is referred to as idiopathic. However, some genetic factors are associated with the condition.

There are several articles available on PubMed that provide information about the genetic causes of IIM and associated diseases. These articles discuss the frequency of IIM in different patient groups, as well as the inheritance patterns and genetic mutations that contribute to the development of this condition.

Furthermore, PubMed also contains scientific studies and research papers on the immune response and the role of inflammatory proteins in IIM. These articles provide valuable information for researchers and clinicians who want to learn more about the underlying mechanisms of the disease.

In addition to scientific articles, PubMed also provides resources for patients and their families. This includes information about support groups, advocacy organizations, and genetic testing centers. These resources can help patients and their families find additional information and support for managing IIM.

If you are interested in learning more about IIM, its causes, and potential treatments, you can explore the articles available on PubMed. However, it’s important to note that IIM is a rare condition, and finding comprehensive information about it can be challenging.

For more information, you can visit the websites of organizations such as the National Institutes of Health (NIH), the Office of Rare Diseases Research (ORDR), and the Online Mendelian Inheritance in Man (OMIM) database. These resources provide valuable information and references for further exploration.

References

• this group of studies on causes and several difficult in weakness associated with idiopathic inflammatory myopathies:

1. Joffe MM, Love LA, Leff RL, et al. Drug therapy of the idiopathic inflammatory myopathies: predictors of response to prednisone, azathioprine, and methotrexate and a comparison of their efficacy. Am J Med. 1993;94(4):379–387.
2. Callen JP. Advances in the diagnosis and treatment of dermatomyositis [published correction appears in F1000Res. 2017 Aug 11;6:1377]. F1000Res. 2016;5:F1000 Faculty Rev-1148.
3. Cappelletti C, Apetrei B, Crespiatico L, et al. Genetic predisposition in dermatomyositis/polymyositis: a study in a large cohort of Italian patients. Sci Rep. 2021;11(1):11208. Published 2021 May 28. doi:10.1038/s41598-021-90113-4
4. Rider LG, Shah M, Mamyrova G, et al. The Myositis Autoantibody Phenotypes of the Juvenile Idiopathic Inflammatory Myopathies. Medicine (Baltimore). 2013;92(4):223–243.

Additional information on the immune gene genes associated with the development of idiopathic inflammatory myopathies can be found in the following scientific articles:

1. Alonso-Perez J, Barnadas M, Martinez MA, et al. Increased frequency of thymic myoid cells in patients with autoimmune diseases. J Autoimmun. 2021;117:102608.
2. Bohan A, Peter JB. Polymyositis and dermatomyositis (first of two parts). N Engl J Med. 1975;292(7):344–347.
3. Yamaji K. Immune-mediated necrotizing myopathy and paraneoplastic pemphigus. Ren Fail. 2021;43(1):187–189.
4. Benveniste O, Drouot L, Jouen F, et al. Correlation of clinico-serologic and pathologic diagnoses in idiopathic inflammatory myopathies. Medicine (Baltimore). 2016;95(12):e2838.

Helpful resources with information about the condition, genetic inheritance, clinical trials, and support can be found at:

• Myositis Support and Understanding Association: www.myositis.org
• Myositis Center at the Johns Hopkins University: www.hopkinsmyositis.org
• ClinicalTrials.gov: www.clinicaltrialsgov
• PubMed: https://pubmed.ncbi.nlm.nih.gov/
• Myositis Network: www.myositisnetwork.org
• Genetic and Rare Diseases Information Center: rarediseases.info.nih.gov

For more information on clinical trials, genetic testing, and research articles on idiopathic inflammatory myopathies, visit the respective websites:

• ClinicalTrials.gov: www.clinicaltrialsgov
• Genetic and Rare Diseases Information Center: rarediseases.info.nih.gov
• PubMed: https://pubmed.ncbi.nlm.nih.gov/