The KLLN gene, also known as the cowden-like gene, is a genetic variant associated with conditions such as Cowden syndrome and cowden-like syndrome. It plays a crucial role in regulating cell growth and division, and any changes in this gene can lead to various health problems, including cancer.

Information about the KLLN gene can be found in various genetic registries and databases. One such resource is the Online Mendelian Inheritance in Man (OMIM) catalog, which provides detailed information, scientific articles, and genetic testing references for genes and related diseases. The KLLN gene is listed in this catalog, along with other genes associated with similar conditions.

Testing for variations in the KLLN gene can be done through genetic testing, which is available in specialized laboratories and clinics. These tests can help diagnose conditions related to the KLLN gene and provide valuable information for managing and treating these conditions.

Research on the KLLN gene and associated conditions is ongoing, and new findings are regularly published in scientific journals. By exploring these articles, healthcare professionals and researchers can stay up-to-date on the latest discoveries and advancements in this field.

Overall, the KLLN gene plays a significant role in a group of conditions known as Cowden-like syndromes. Understanding the changes and tests related to this gene can provide valuable insight into the diagnosis and treatment of these conditions, as well as contribute to the development of targeted therapies and interventions.

Genetic changes, also known as variants, in the KLLN gene have been linked to several health conditions. These changes can be identified through genetic testing, providing important information for diagnosis and management.

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One of the most well-known conditions associated with changes in the KLLN gene is Cowden syndrome. This rare genetic disorder is characterized by an increased risk of developing certain types of cancer, such as breast, thyroid, and endometrial cancer. Individuals with Cowden syndrome often have multiple non-cancerous growths called hamartomas.

In addition to Cowden syndrome, genetic changes in the KLLN gene have also been linked to Cowden-like syndrome, which shares similar features with Cowden syndrome but does not meet the specific diagnostic criteria. It is important to note that both Cowden syndrome and Cowden-like syndrome are relatively rare conditions.

Scientific research has identified other health conditions related to changes in the KLLN gene. However, many of these conditions are not well-described in the medical literature and may not have established names or diagnostic criteria.

To learn more about the health conditions associated with changes in the KLLN gene, it is recommended to consult the Online Mendelian Inheritance in Man (OMIM) database and PubMed for related articles and scientific references.

Genetic testing for KLLN gene variants can be conducted through various testing groups, laboratories, and resources. These tests can provide valuable information for diagnosis, management, and genetic counseling.

It is important to note that a genetic change in the KLLN gene does not necessarily mean that the individual will develop any of the associated health conditions. Genetic changes can have variable effects, and the presence of a variant does not always result in disease.

For additional information and resources on genetic testing, diseases, and conditions related to KLLN gene changes, the National Institutes of Health’s Genetic and Rare Diseases Information Center (GARD) and the Catalog of Human Genes and Genetic Disorders (GeneCards) can provide useful information and references.

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Cowden Syndrome

Cowden syndrome is a genetic condition that increases the risk of developing certain types of cancer. It is caused by changes in the KLLN gene.

Individuals with Cowden syndrome have an increased risk of developing breast, thyroid, and endometrial cancer. Other features of the syndrome can include macrocephaly, multiple hamartomas, and mucocutaneous manifestations.

The KLLN gene, also known as PTEN, is a tumor suppressor gene. Changes in this gene can lead to the development of Cowden syndrome. Genetic testing can be done to identify changes in the KLLN gene and confirm a diagnosis of Cowden syndrome.

For more information on Cowden syndrome, references and articles can be found on the PubMed database. Other resources include the GeneReviews and OMIM databases, which provide additional information on genetic conditions related to Cowden syndrome.

Testing for changes in the KLLN gene can be done through various genetic testing labs and companies. It is recommended that individuals with a family history of Cowden syndrome or related conditions speak with a healthcare provider about their risk and the possibility of genetic testing.

In addition to changes in the KLLN gene, other genes and genetic changes have been associated with Cowden-like conditions. Scientific research and studies are ongoing to better understand the genetic factors that contribute to these conditions.

This article serves as a general overview of Cowden syndrome and should not be used as a substitute for professional medical advice. For specific information and guidance, individuals are encouraged to consult with healthcare professionals and experts in the field.

Other Names for This Gene

  • OMIM – KLLN
  • Genetic Region – Listed under the KLLN gene
  • For More Information – Related articles from OMIM, tests and articles from the Cowden Syndrome and Cowden-like Syndrome registry, and scientific resources on cancer
  • Related Genes – Genes that are known to be related to KLLN
  • Health Conditions and Diseases – Information on conditions and diseases associated with variants in the KLLN gene
  • Gene Testing Registry – Additional information on gene testing for KLLN
  • Known Changes – Known changes in the KLLN gene
  • References – References to scientific articles and databases that contain information on KLLN

Additional Information Resources

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive database that provides information on genetic disorders and conditions. The KLLN gene and associated diseases are listed in OMIM, and you can find more information about the gene, its variants, and related conditions on this database.
  • Cowden Syndrome Gene Variant Database: This database specifically focuses on genetic changes in the KLLN gene associated with Cowden syndrome and related conditions. It provides detailed information on different gene variants, their prevalence, and their impact on health.
  • Scientific Articles and References: Numerous scientific articles and research papers have been published on the KLLN gene, its functions, and its involvement in different diseases. PubMed is a well-known repository for scientific publications, where you can find a vast amount of information on the KLLN gene and related topics.
  • Genetic Testing and Health Registry: Genetic testing is available to identify changes in the KLLN gene and to assess their implications for health. Various laboratories and testing facilities offer KLLN gene testing, and the results can be registered in health registries to contribute to the scientific understanding of this gene and its associated conditions.
  • Genetic Conditions and Diseases Catalog: The KLLN gene is associated with a range of genetic conditions and diseases. The Genetic Conditions and Diseases Catalog provides a comprehensive list of these conditions, along with detailed information about their genetic causes, symptoms, and available treatments.
  • Other Genetic Resources: In addition to the resources mentioned above, there are several other databases and resources available that provide information on genes, genetic tests, and related conditions. These resources can be helpful in gaining a broader understanding of the KLLN gene and its significance in health and disease.
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Tests Listed in the Genetic Testing Registry

Genetic testing is an important tool in diagnosing and understanding various conditions and diseases. The KLLN gene is associated with several genetic conditions, including Cowden syndrome and Cowden-like syndrome. Below is a list of tests related to the KLLN gene that have been listed in the Genetic Testing Registry:

  • Cowden syndrome (OMIM 158350) – This test examines changes or variants in the KLLN gene that are associated with Cowden syndrome. Cowden syndrome is a genetic condition that increases the risk of developing certain types of cancer, including breast, thyroid, and uterine cancer.

  • Cowden-like syndrome (OMIM 615106) – This test looks for changes or variants in the KLLN gene that are associated with Cowden-like syndrome. Cowden-like syndrome is a similar condition to Cowden syndrome, but it does not meet all the diagnostic criteria for Cowden syndrome.

These tests provide valuable information about the genetic changes or variants in the KLLN gene that may contribute to the development of these conditions. The results of these tests can help healthcare providers make more accurate diagnoses and provide appropriate care and management strategies for individuals with these conditions.

In addition to the Genetic Testing Registry, there are other resources that provide information on genetic tests related to the KLLN gene. These include scientific articles in PubMed and the Online Mendelian Inheritance in Man (OMIM) database, as well as databases and catalogs from various genetic testing groups.

Scientific Articles on PubMed

  • Variant KLLN gene: This article discusses the variant KLLN gene and its association with certain health conditions and syndromes. It provides information on the changes in the gene and its impact on different diseases.
  • Catalog of genetic diseases: A comprehensive catalog of genetic diseases is presented, including conditions associated with KLLN gene variations. The catalog provides detailed information on each condition and its genetic basis.
  • Registry of KLLN gene: A registry is established to collect and organize information on KLLN gene variants. This registry serves as a valuable resource for researchers, healthcare professionals, and individuals seeking information about these variants.
  • Testing resources and guidelines: This article provides an overview of available testing resources and guidelines for testing KLLN gene variants. It discusses the importance of genetic testing and provides recommendations for individuals and healthcare providers.
  • Related genes and their role: The article explores the relationship between KLLN gene and other genes implicated in similar conditions. It highlights the importance of studying related genes to better understand the underlying mechanisms of these conditions.
  • OMIM database: The OMIM database is a valuable resource for researchers and clinicians seeking information on genetic disorders. It contains a detailed list of genes related to KLLN and provides references to relevant articles and studies.
  • Cowden-like syndrome: This article discusses Cowden-like syndrome, a condition related to KLLN gene variants. It provides an overview of the syndrome, its symptoms, and the role of KLLN gene in its development.
  • Additional testing and screening: The article highlights the importance of additional testing and screening for individuals with KLLN gene variants. It discusses the different tests and screening methods available and their implications for early detection and treatment of associated conditions.
  • Protein changes and their impact: This article focuses on the protein changes resulting from KLLN gene variants. It discusses the functional impact of these changes and their role in the development of various diseases and conditions.
  • Articles on PubMed: A comprehensive collection of articles on PubMed related to the KLLN gene and its associated conditions is provided. These articles provide detailed information on the latest research, studies, and discoveries in this field.

In conclusion, the scientific articles available on PubMed provide valuable information on the KLLN gene, its variants, related genes, associated diseases and conditions, genetic testing resources, and other important insights. Researchers and healthcare professionals can utilize these articles to enhance their understanding of the topic and provide better care to individuals with KLLN gene variants.

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Catalog of Genes and Diseases from OMIM

The Catalog of Genes and Diseases from OMIM is a comprehensive resource that provides information about various genetic conditions and diseases. It includes a wide range of genes and diseases, listed alphabetically, with each entry containing detailed information about the associated genetic changes, protein variants, and known health implications.

OMIM, or Online Mendelian Inheritance in Man, is a scientific database that collects and maintains information about genetic conditions and diseases. It serves as a valuable reference for researchers, healthcare professionals, and individuals interested in understanding the genetic basis of various health conditions.

The catalog includes genes and diseases from various sources, including OMIM articles, other scientific databases, PubMed references, and additional resources. It provides a comprehensive overview of the genetic changes and associated health conditions caused by these genes.

In the context of the KLLN gene, which is associated with Cowden-like syndrome, the catalog provides detailed information about the genetic changes, protein variants, and testing options available for this gene. It also lists the associated health conditions and references to scientific articles and studies related to the KLLN gene and Cowden-like syndrome.

The catalog organizes the genes and diseases into different groups, making it easier to navigate and find relevant information. It provides a valuable resource for researchers and healthcare professionals involved in the study and management of genetic conditions.

Overall, the Catalog of Genes and Diseases from OMIM is a comprehensive and reliable resource for understanding the genetic basis of various health conditions. It provides information on the genetic changes, protein variants, and associated health conditions for a wide range of genes. Researchers and healthcare professionals can utilize this catalog to enhance their understanding of genetic conditions and devise appropriate testing and management strategies.

Gene and Variant Databases

klln gene and variant databases provide valuable information and resources for understanding and testing various diseases and conditions related to the KLLN gene. These databases offer a wealth of information on the health impact of changes in this gene and related conditions, as well as references to additional articles and scientific publications.

The Cowden Syndrome and Cowden-like Syndrome Databases are two notable resources in this area. These databases document the names of genes known to cause Cowden syndrome, a genetic condition associated with an increased risk of a variety of cancers. They also catalog variants in these genes, providing crucial information for genetic testing and research.

Other databases, such as OMIM (Online Mendelian Inheritance in Man), offer comprehensive information on various diseases and conditions. OMIM provides detailed descriptions of genes, known protein changes, and associated conditions. This database serves as a useful reference for researchers and healthcare professionals.

In addition to these databases, there are also resources specific to testing for changes in the KLLN gene. These testing databases provide information on available tests, their reliability, and their relevance to specific diseases or conditions.

Overall, gene and variant databases play a crucial role in understanding the impact of genetic changes on health and disease. They provide a valuable resource for researchers, healthcare professionals, and individuals seeking information on genetic conditions.

References

  • Conditions related to the KLLN gene: Cowden syndrome, Cowden-like syndrome, and changes in cancer susceptibility genes listed in the OMIM database
  • Scientific articles on testing and changes in the KLLN gene: PubMed
  • Additional resources and information on health conditions and genetic testing: OMIM
  • Other genes known to change the susceptibility to Cowden-like conditions: Cowden syndrome region genes listed in the OMIM database
  • Information and resources from the Cowden Syndrome and Cowden-like Syndrome Registry