What are the benefits of lion s mane mushrooms

Controlling blood sugar levels is key to managing diabetes. In one study , blood sugar levels in rats with diabetes were lower after they received lion’s mane mushroom extract for 4 weeks.

9 Health Benefits of Lion’s Mane Mushroom (Plus Side Effects)

Lion’s mane mushrooms are large, white, shaggy mushrooms that resemble a lion’s mane as they grow. They contain bioactive substances that have many beneficial effects on the body, especially the brain, heart, and gut.

Lion’s mane mushrooms, also known as hou tou gu or yamabushitake, have both culinary and medicinal uses in Asian countries like China, India, Japan, and Korea ( 1 ).

Here are nine health benefits of lion’s mane mushrooms and their extracts, along with dosages, preparation, and side effects.

The brain’s ability to grow and form new connections typically declines with age, which may explain why mental functioning worsens in many older adults ( 2 ).

Studies have found that lion’s mane mushrooms contain two special compounds that can stimulate the growth of brain cells: hericenones and erinacines ( 3 ).

Fears over not being able to afford health insurance or medical care are among the top reasons why Americans are delaying retirement. From 2000 to 2016, the number of Americans 65 and older working full-time or part-time rose by six% to include almost 9 million people, according to the Pew Research Center.

Additionally, animal studies have found that lion’s mane may help protect against Alzheimer’s disease, a degenerative brain disease that causes progressive memory loss.

In fact, lion’s mane mushroom and its extracts have been shown to reduce symptoms of memory loss in mice, as well as prevent neuronal damage caused by amyloid-beta plaques, which accumulate in the brain during Alzheimer’s disease ( 4 , 5 , 6 ).

A 2020 study of people with mild Alzheimer’s disease found that supplementation with 1 gram of lion’s mane mushroom daily for 49 weeks significantly improved cognitive test scores compared with a placebo ( 7 ).

The ability of lion’s mane mushroom to promote nerve growth and protect the brain from Alzheimer’s-related damage may explain some of its beneficial effects on brain health.

However, it’s important to note that most of the research has been conducted on animals or in test tubes. Therefore, more human studies are needed.

Summary

Lion’s mane mushrooms contain compounds that stimulate brain cell growth and protect them from damage caused by Alzheimer’s disease. However, more research involving humans is needed.

Up to one-third of people living in developed countries experience symptoms of anxiety and depression (8, 9).

While there are many causes of anxiety and depression, chronic inflammation could be a major contributing factor.

Animal research has found that lion’s mane mushroom extract has anti-inflammatory effects that can reduce symptoms of anxiety and depression in mice ( 10 ).

Other animal studies have found that lion’s mane extract can also help regenerate brain cells and improve the functioning of the hippocampus, a region of the brain that processes memories and emotional responses ( 11 , 12 ).

Researchers believe that improved hippocampus functioning may explain the reductions in anxious and depressive behaviors in mice receiving these extracts.

While these animal studies are promising, there is very little research involving humans.

One small 2010 study of menopausal women found that eating cookies containing lion’s mane mushrooms daily for 1 month helped reduce self-reported feelings of irritation and anxiety ( 13 , 14 ).

Summary

Studies suggest that lion’s mane mushrooms may help relieve mild symptoms of anxiety and depression, but more research involving humans is needed to better understand the correlation.

The nervous system consists of the brain, spinal cord, and other nerves that travel throughout the body. These components work together to send and transmit signals that control almost every bodily function.

Brain or spinal cord injuries can cause various adverse medical outcomes. They often cause paralysis or loss of mental functions and can take a long time to heal.

However, research has found that lion’s mane mushroom extract may help speed recovery from these types of injuries by stimulating the growth and repair of nerve cells ( 15 , 16 ). It may also help reduce the severity of brain damage after a stroke.

However, no studies have been conducted involving humans to determine if lion’s mane would have the same therapeutic effect on nervous system injuries as animal research has suggested.

Summary

Rat studies have found that lion’s mane extract can speed up recovery from nervous system injuries, but research involving humans is lacking.

Ulcers can form anywhere along the digestive tract, including the stomach, small intestine, and large intestine.

What are the benefits of lion’s mane mushrooms?

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Lion’s mane mushrooms (Hericium erinaceus) are white, globe-shaped fungi that have long, shaggy spines. People can eat them or take them in the form of supplements. Research suggests that they may offer a range of health benefits, including reduced inflammation and improved cognitive and heart health.

People in Asia use these mushrooms for both culinary and medicinal purposes. Health food stores sell lion’s mane extract in supplement form, and both the fungus and its extracts appear to be beneficial to health.

Here we discuss the potential benefits of lion’s mane mushrooms and consider the possible risks and side effects of their use.

Lion’s mane mushrooms may help with the following:

Inflammation and oxidation

Share on Pinterest Lion’s mane mushrooms may offer a number of health benefits.

Antioxidants may fight both inflammation and oxidation in the body.

Inflammation contributes to many medical conditions, including diabetes, heart disease, and autoimmune diseases.

A 2012 study evaluating the medicinal potential of 14 types of mushroom found that lion’s mane had the fourth highest antioxidant activity, which researchers described as “moderate to high.”

Immune function

Lion’s mane mushrooms may enhance the immune system, partly by reducing inflammation and preventing oxidation.

Research on mice suggests that lion’s mane mushrooms may boost the activity of the intestinal immune system.

The results of another study on mice indicate that a protein in lion’s mane mushrooms encourages the growth of beneficial gut bacteria that strengthen immunity.

Anxiety and depression

Extracts from lion’s mane mushrooms may be beneficial in the treatment of anxiety and depression.

In a 2015 study , mice that consumed lion’s mane mushroom extract displayed fewer depressive behaviors and had blood markers that indicated lower depression. The researchers suggest that this is due to the extract’s anti-inflammatory effects.

The findings of a 2018 animal study support this, with the authors concluding that these mushroom extracts may contain agents that are useful for treating depressive disorders.

In a small Japanese study, women with a variety of health complaints, including menopausal symptoms and poor sleep quality, ate cookies containing lion’s mane extracts or placebo cookies for 4 weeks. The participants who ate the extract reported lower levels of irritation and anxiety than those in the placebo group.

Cognitive health

It is possible that lion’s mane mushrooms might boost cognitive function, but the existing research is mainly on animals.

In one study , lion’s mane dietary supplements appeared to give mice better object recognition and recognition memory.

Other researchers have concluded that the mushrooms may have the potential to treat or prevent diseases that cause a decline in cognitive health, such as Parkinson’s disease and Alzheimer’s disease.

Heart health

Lion’s mane extract may improve heart health, but the research to date has primarily used animal subjects.

Research on rats showed that the mushroom extracts might have a cholesterol-lowering effect.

Cancer

The antioxidant properties of lion’s mane mushrooms may play a role in cancer prevention or treatment.

The results of an in vitro study indicate that lion’s mane extracts have therapeutic potential against human leukemia.

A study using animal models found that these mushroom extracts may also fight liver, colon, and gastric cancer cells.

These findings are promising, but it is not currently possible to confirm that the same effects will apply in people.

Diabetes

Controlling blood sugar levels is key to managing diabetes. In one study , blood sugar levels in rats with diabetes were lower after they received lion’s mane mushroom extract for 4 weeks.

One of the complications of diabetes is nerve damage resulting from prolonged periods of high blood sugar. A 2015 study on rats, in which they ingested lion’s mane extract for 6 weeks, showed positive results, including lower blood sugar levels, reduced feelings of nerve pain, and improved antioxidant activity.

Digestive health

Lion’s mane may help digestive health by fighting inflammation, which could be beneficial for people with inflammatory bowel disease (IBD). The mushroom may also boost immune function and encourage the growth of good bacteria in the gut.

In vitro studies report that lion’s mane mushrooms can result in antibacterial activity that may improve digestion. Research in mice supports these findings by showing that extracts of lion’s mane may protect against stomach ulcers.

Wound healing

Extracts from lion’s mane mushrooms may provide healing benefits for skin wounds.

A study on rats with neck wounds found that topical application of lion’s mane extract led to faster healing.

However, more extensive research is necessary for the medical community to recommend lion’s mane mushrooms for topical use on humans.

Nervous system recovery

Damage to the nervous system can have significant effects on health.

Some research suggests that extracts of lion’s mane mushrooms may encourage nerve cells to grow and repair more quickly.

One study showed that rats with nerve damage receiving a daily extract of lion’s mane mushrooms had quicker nerve regeneration than control animals.

Most studies on lion’s mane mushrooms have used animals, but it appears to be safe to eat the mushrooms in moderate quantities, as people do in many countries in Asia.

The safety and effectiveness of lion’s mane supplements are less apparent because dietary supplements do not have the same regulations as food and drug products.

However, in the animal studies, even high doses did not produce adverse effects in the rodents.

Share on Pinterest People can take lion’s mane mushroom as a supplement.

People wishing to incorporate lion’s mane mushrooms into their diet should cook them until the outer layer is crispy as the taste can be bitter otherwise.

Supplements are available in stores and online in the following forms:

The dosages of these supplements vary, and people should follow the instructions on the label carefully. It is also advisable to discuss the use of any new supplement with a doctor.

People who experience adverse reactions to lion’s mane mushrooms should stop using them and seek immediate medical attention.

Lion’s mane mushrooms and their extracts show promise in animal and in vitro studies. However, there is not yet enough evidence to support their use for the treatment or prevention of any health condition in humans.

It should be safe for most people to enjoy lion’s mane mushrooms for culinary purposes. However, people who wish to take lion’s mane supplements should speak to a doctor first.

Last medically reviewed on October 22, 2018

Nutrition / Diet
Complementary Medicine / Alternative Medicine

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Abdulla, M. A., Fard, A. A., Sabaratnam, V., Wong, K. H., Kuppusamy, U. R., Abdullah, N., & Ismail, S. (2011). Potential activity of aqueous extract of culinary-medicinal lion’s mane mushroom, Hericium erinaceus (Bull.: Fr.) Pers. (Aphyllophoromycetideae) in accelerating wound healing in rats [Abstract]. International Journal of Medicinal Mushrooms, 13(1), 33–39
https://www.ncbi.nlm.nih.gov/pubmed/22135902
Abdullah, N., Ismail, S. M., Aminudin, N., Shuib, A. S., & Lau, B. F. (2012). Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. Evidence-Based Complementary and Alternative Medicine, 2012
https://www.hindawi.com/journals/ecam/2012/464238/
Brandalise, F., Cesaroni, V., Gregori, A., Repetti, M., Romano, C., Orrù, G., . Rossi, P. (2017, January 1). Dietary supplementation of Hericium erinaceus increases mossy fiber-CA3 hippocampal neurotransmission and recognition memory in wild-type mice. Evidence-Based Complementary and Alternative Medicine, 2017
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5237458/
Chiu, C.-H., Chyau, C.-C., Chen, C.-C., Lee, L.-Y., Chen, W.-P., Liu, J.-L., . Mong, M.-C. (2018, February). Erinacine A-enriched Hericium erinaceus mycelium produces antidepressant-like effects through modulating BDNF/PI3K/Akt/GSK-3β signaling in mice. International Journal of Molecular Sciences, 19(2), 341
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5855563/
Choi, W.-S., Kim, Y.-S., Park, B.-S., Kim, J.-E., & Lee, S.-E. (2013, June 30). Hypolipidaemic effect of Hericium erinaceum grown in Artemisia capillaris on obese rats. Mycobiology, 41(2), 94–99
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3714447/
Diling, C., Chaoqun, Z., Jian, Y., Jian, L., Jiyan, S., Yizhen, X., & Guoxiao, L. (2017, June 12). Immunomodulatory activities of a fungal protein extracted from Hericium erinaceus through regulating the gut microbiota. Frontiers in Immunology, 8, 666
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5492111/
Kim, S. P., Kang, M. Y., Choi, Y. H., Kim, J. H., Nam, S. H., & Friedman, M. (2011, June 8). Mechanism of Hericium erinaceus (Yamabushitake) mushroom-induced apoptosis of U937 human monocytic leukemia cells [Abstract]. Food & Function, 2(6), 348–356
https://www.ncbi.nlm.nih.gov/pubmed/21779573
Lakshmanan, H., Raman, J., David, P., Wong, K. H., Naidu, M., & Sabaratnam, V. (2016, December 24). Haematological, biochemical and histopathological aspects of Hericium erinaceus ingestion in a rodent model: A sub-chronic toxicological assessment [Abstract]. Journal of Ethnopharmacology, 194, 1051–1059
https://www.ncbi.nlm.nih.gov/pubmed/27816657
Li, G., Yu, K., Li, F., Xu, K., Li, J., He, S., . Tan, G. (2014, April 28). Anticancer potential of Hericium erinaceus extracts against human gastrointestinal cancers [Abstract]. Journal of Ethnopharmacology, 153(2), 521–530
https://www.ncbi.nlm.nih.gov/pubmed/24631140
Liang. B., Guo, Z., Xie, F., & Zhai, A. (2013, October 3). Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complementary and Alternative Medicine, 2013(13), 253
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852124/#__ffn_sectitle
Liu, J. H., Li, L., Shang, X. D., Zhang, J. L., & Tan, Q. (2016, May 13). Anti-Helicobacter pylori activity of bioactive components isolated from Hericium erinaceus [Abstract]. Journal of Ethnopharmacology, 183, 54–58
https://www.ncbi.nlm.nih.gov/pubmed/26364939
Mori, K., Inatomi, S., Ouchi, K., Azumi, Y., & Tuchida, T. (2009, March). Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: A double&dash;blind placebo&dash;controlled clinical trial [Abstract]. Phytotherapy Research, 23(3), 367–372
https://www.ncbi.nlm.nih.gov/pubmed/18844328
Nagano, M., Shimizu, K., Kondo, R., Hayashi, C., Sato, D., Kitagawa, K., & Ohnuki, K. (2010, August). Reduction of depression and anxiety by 4 weeks Hericium erinaceus intake. Biomedical Research, 31(4), 231–237
https://www.jstage.jst.go.jp/article/biomedres/31/4/31_4_231/_pdf/-char/en
Samberkar, S., Gandhi, S., Naidu, M., Wong, K. H., Raman, J., & Sabaratnam, V. (2015). Lion’s mane, Hericium erinaceus and tiger milk, Lignosus rhinocerotis (higher basidiomycetes) medicinal mushrooms stimulate neurite outgrowth in dissociated cells of brain, spinal cord, and retina: An in vitro study [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1047–1054
https://www.ncbi.nlm.nih.gov/pubmed/26853959
Sheng, X., Yan, J., Meng, Y., Kang, Y., Han, Z., Tai, G., . Cheng, H. (2017, March 22). Immunomodulatory effects of Hericium erinaceus derived polysaccharides are mediated by intestinal immunology [Abstract]. Food & Function, 8(3), 1020–1027
https://www.ncbi.nlm.nih.gov/pubmed/28266682
Wang, M., Konishi, T., Gao, Y., Xu, D., & Gao, Q. (2015). Anti-gastric ulcer activity of polysaccharide fraction isolated from mycelium culture of lion’s mane medicinal mushroom, Hericium erinaceus (higher basidiomycetes) [Abstract]. International Journal of Medicinal Mushrooms, 17(11), 1055–1060
https://www.ncbi.nlm.nih.gov/pubmed/26853960
Wong, K.-H., Naidu, M., David, P., Abdulla, M. A., Abdullah, N., Kuppusamy, U. R., & Sabaratnam, V. (2011, August 11). Peripheral nerve regeneration following crush injury to rat peroneal nerve by aqueous extract of medicinal mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae). Evidence-Based Complementary and Alternative Medicine, 2011
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3176599/
Yao, W., Zhang, J. C., Dong, C., Zhuang, C., Hirota, S., Inanaga, K., & Hashimoto, K. (2015, September). Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration [Abstract]. Pharmacology, Biochemistry, and Behavior, 136, 7–12
https://www.ncbi.nlm.nih.gov/pubmed/26150007
Yi, Z., Shao-long, Y., Ai-hong, W., Zhi-chun, S., Ya-fen, Z., Ye-ting, X., & Yu-ling, H. (2015, April 16). Protective effect of ethanol extracts of Hericium erinaceus on alloxan-induced diabetic neuropathic pain in rats. Evidence-based Complementary and Alternative Medicine, 2015
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4415746/
Zhang, J., An, S., Hu, W., Teng, M., Wang, X., Qu, Y., . Wang, D. (2016, November 1). The neuroprotective properties of Hericium erinaceus in glutamate-damaged differentiated PC12 cells and an Alzheimer’s disease mouse model. International Journal of Molecular Sciences, 17(11), 1810
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133811/

What are the benefits of lion s mane mushrooms

9 Health Benefits of Lion’s Mane Mushroom (Plus Side Effects)

What are the benefits of lion’s mane mushrooms?