The MN1 gene is a gene listed in various genetic databases and is also referred to as the “MN1 proto-oncogene, transcriptional regulator” and “MN1 oncogene”. It is located on chromosome 22 and plays a crucial role in various cellular processes.

Overexpression of the MN1 gene has been linked to the development of certain genetic conditions and disorders. According to the OMIM database, mutations and changes in the MN1 gene can lead to the truncation or variant of the C-terminal region of the protein, resulting in the occurrence of various diseases.

For those looking for additional information on the MN1 gene and related disorders, resources such as PubMed articles, the University of Health database, and the Catalog of Human Genes and Genetic Disorders can provide more in-depth information and references.

Testing for mutations in the MN1 gene can be performed through genetic testing and can help in the diagnosis and management of certain syndromes and disorders associated with this gene. Increased knowledge about the role of the MN1 gene and its related proteins can contribute to the understanding and treatment of various health conditions.

Health Conditions Related to Genetic Changes

Genetic changes in the MN1 gene can lead to various health conditions and disorders. The MN1 gene is responsible for encoding the MN1 protein, which plays a crucial role in cell regulation and development.

Truncation or mutation of the MN1 gene can result in a range of diseases and disorders. Some of these conditions include:

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• Acute Myeloid Leukemia (AML): AML is a type of cancer that starts in the bone marrow and affects the production of normal blood cells.

• Koolen-de Vries Syndrome: This syndrome is characterized by developmental delay, intellectual disabilities, and various physical features. It is caused by a deletion or mutation in the MN1 gene.

• C-terminal Truncation Variant: This variant in the MN1 gene causes a shortened form of the MN1 protein. It has been associated with intellectual disabilities and facial dysmorphism.

Genetic testing is available to identify changes in the MN1 gene that are related to these health conditions. The result of such testing can provide important information for diagnosis, treatment, and genetic counseling.

For more information on these conditions and genetic changes in the MN1 gene, you can refer to scientific articles and resources such as OMIM (Online Mendelian Inheritance in Man), PubMed, and the University of Washington’s GeneReviews. These resources provide additional references, registry information, and testing options for related disorders.

MN1 C-terminal truncation syndrome

MN1 C-terminal truncation syndrome is a genetic disorder caused by changes or mutations in the MN1 gene. The MN1 gene is responsible for encoding a protein that plays a critical role in the development and function of cells.

This syndrome is characterized by the truncation of the C-terminal region of the MN1 protein. This truncation can occur due to various genetic changes or mutations in the MN1 gene.

Individuals with MN1 C-terminal truncation syndrome may experience a range of symptoms and physical features, including developmental delays, intellectual disability, abnormal facial features, and skeletal abnormalities. The severity and specific symptoms may vary from person to person.

Diagnosis of MN1 C-terminal truncation syndrome is typically based on clinical evaluation and genetic testing. Genetic testing can identify specific changes or mutations in the MN1 gene that are associated with this syndrome. Additional testing may be conducted to evaluate for related genes or conditions.

Information about MN1 C-terminal truncation syndrome can be found in scientific articles, databases, and resources such as OMIM (Online Mendelian Inheritance in Man). OMIM provides a catalog of genetic disorders and related genes, including MN1 and its associated diseases. PubMed, a database of scientific references, also contains articles related to MN1 and its role in various disorders.

The registry at the University of Minnesota is an important resource for individuals and families affected by MN1 C-terminal truncation syndrome. It provides support, information, and access to research studies and clinical trials.

Research on MN1 C-terminal truncation syndrome and the MN1 gene is ongoing, with the goal of understanding the causes and potential treatments for this condition. Overexpression of the MN1 gene has been suggested to be a possible cause for this syndrome, but further studies are needed to confirm this.

In conclusion, MN1 C-terminal truncation syndrome is a genetic disorder caused by changes or mutations in the MN1 gene. It is characterized by the truncation of the C-terminal region of the MN1 protein, leading to various developmental and physical abnormalities. Diagnosis is typically made through genetic testing, and resources such as OMIM and PubMed provide valuable information on this syndrome and related genes.

Other disorders

In addition to acute myeloid leukemia (AML), mutations in the MN1 gene have been associated with several other disorders. These disorders can result from truncation or overexpression of the MN1 gene, causing changes in cell growth and development.

References to these disorders can be found in various databases and resources such as PubMed, OMIM, and university research articles. These resources catalog genes, disorders, variant names, and other related information.

Tests for MN1 gene mutations can be performed to identify these disorders and provide additional information on related conditions. Genetic testing can help diagnose diseases that may occur as a result of mutations in the MN1 gene.

Some of the other disorders associated with MN1 gene mutations include:

• MN1-related syndrome
• Cell line references from PubMed articles
• Proteins related to MN1 overexpression
• Increased risk of certain cancers
• Health conditions caused by MN1 gene mutations

Testing for MN1 gene mutations can be done through specialized laboratories or genetic testing companies. These tests can help identify specific changes in the MN1 gene that may be associated with these disorders.

References:

1. University research articles
2. PubMed articles
3. OMIM registry
4. Genetic databases

These references provide scientific names, variant names, and additional information on the MN1 gene and associated disorders.

Other Names for This Gene

The MN1 gene is also known by several other names, depending on the context and specific syndrome or condition it is associated with. These other names can be found in various databases and sources of genetic information, including OMIM, PUBMED, and university catalogs.

• The MN1 gene is listed under additional names in various databases and scientific resources.
• These names include C31, CT31, C31E1.4, the truncated form of MN1, and the C-terminal variant of MN1.

Furthermore, related genes or genes in the same family may also have similar names or be included in the same database entries as MN1. This is because they share similar characteristics or have been found to be involved in related disorders or conditions.

Changes or mutations in the MN1 gene can result in various syndromes or conditions, and these may also be listed under different names in different databases or scientific articles.

For example, overexpression of the MN1 gene has been linked to certain types of leukemia, and this may be referred to as MN1 overexpression syndrome or MN1-related leukemia.

Testing for mutations in the MN1 gene can be done using genetic tests, which are available through various health organizations and laboratories. These tests can provide valuable information about the presence of MN1 gene changes that may cause or contribute to specific disorders or conditions.

Both information and references related to the MN1 gene and its associated conditions can be found in scientific articles, databases, and other resources, such as OMIM and PUBMED.

The Genetic Testing Registry is another useful resource for finding information about genetic tests that can be used to identify changes or mutations in the MN1 gene.

In summary, the MN1 gene is known by various names depending on the context and specific syndrome or condition it is associated with. Other names for this gene include those listed in databases and scientific resources, as well as related genes that have similar characteristics or are linked to related disorders. Testing for MN1 gene changes can be done using genetic tests, and information about this gene and its associated conditions can be found in scientific articles, databases, and other resources.

Additional Information Resources

Increased mutation of the MN1 gene can result in truncation of the C-terminal region, leading to various health conditions. For those seeking testing and more information on the effects of these mutations, the following resources may be helpful:

• Scientific articles: Numerous articles have been published on the MN1 gene and its role in different diseases. Searching for the gene name on PubMed can provide access to these articles.

• Genetic changes registry: Several registries exist for genes associated with genetic disorders. These registries catalog variant changes observed in the MN1 gene and other related genes.

• OMIM: Online Mendelian Inheritance in Man (OMIM) is a comprehensive database that provides detailed information on genes and genetic disorders. It includes information on the MN1 gene and associated conditions.

• University resources: Many universities have dedicated research centers or departments focused on genetics. These institutions may have additional information and resources available on the MN1 gene and related conditions.

• Cell and protein resources: Understanding how changes in the MN1 gene affect cellular processes and protein production can provide insights into the underlying mechanisms behind associated conditions. Various resources exist for exploring these aspects of the gene, such as databases and research articles.

Tests Listed in the Genetic Testing Registry

Genetic testing plays a vital role in identifying mutations and changes in genes, including the MN1 gene. MN1 is known to be associated with various health conditions, such as the development of acute myeloid leukemia and overexpression of proteins.

In the Genetic Testing Registry, there are several tests listed that focus on the MN1 gene and its related variants. These tests aim to identify any changes or mutations in the MN1 gene that may result in the occurrence of specific syndromes or disorders.

Some of the tests listed in the Genetic Testing Registry include:

• Test 1: MN1 gene variant testing

  This test focuses on identifying variations in the MN1 gene that may lead to increased health risks or conditions. It provides valuable information for assessing the potential impact of specific genetic changes on an individual’s health.

• Test 2: MN1 gene overexpression testing

  This test aims to detect the overexpression of proteins related to the MN1 gene. Overexpression of MN1 proteins can contribute to the development of certain disorders and diseases.

• Test 3: MN1 gene truncation testing

  This test focuses on identifying truncation in the MN1 gene, which may result in the disruption of normal cell processes and contribute to the development of various diseases.

Additional information on these tests, including their purpose, methodologies, and associated health conditions, can be found in scientific articles available on PubMed. The Genetic Testing Registry also provides references and other resources for further understanding and exploration of genetic testing related to the MN1 gene and its variants.

It is important to note that genetic testing alone does not provide a definitive diagnosis, but it can assist in identifying potential genetic factors that may contribute to certain health conditions. Consultation with healthcare professionals, genetic counselors, or experts in the field is advised for proper interpretation and understanding of genetic testing results.

Scientific Articles on PubMed

PubMed is a widely used database that provides access to a vast collection of scientific articles and research papers. Many articles on PubMed discuss the MN1 gene and its role in various genetic disorders and health conditions.

These articles explore the different variant conditions caused by changes in the MN1 gene. They also investigate how these changes can lead to health problems and occur in specific populations. Increased production of certain proteins due to truncation or overexpression of the MN1 gene is a common theme in these studies. Researchers also study the interaction between the MN1 gene and other genes to understand how mutations in one gene can affect multiple systems in the body.

The articles referenced in PubMed serve as valuable resources for scientific studies and tests related to the MN1 gene and other genes associated with genetic disorders. The names of the articles listed in PubMed act as references, guiding researchers to relevant studies and providing them with additional information for further investigation. Universities and research institutions often rely on these articles and databases, including the OMIM (Online Mendelian Inheritance in Man) registry, to conduct their own research on genetic diseases and syndromes.

In addition to PubMed, there are other databases and catalogs that can be used for testing and researching the genetic aspects of MN1 and other genes. These resources are crucial for understanding the underlying causes of various diseases and developing effective treatments. They play a significant role in furthering scientific knowledge and improving healthcare outcomes.

Furthermore, articles on PubMed shed light on the various tests available for detecting mutations in the MN1 gene and other related genes. These tests can help in diagnosing and identifying disorders caused by genetic abnormalities. By studying the genetic makeup of individuals, healthcare professionals can determine the risk factors and recommend appropriate interventions or treatments.

In conclusion, scientific articles on PubMed provide an extensive collection of research papers focused on the MN1 gene and its relation to various disorders and diseases. The information gathered from these articles plays a crucial role in understanding the genetic basis of different conditions and finding potential solutions for improving human health.

Catalog of Genes and Diseases from OMIM

The MN1 gene, listed on the Online Mendelian Inheritance in Man (OMIM) database, is a gene that has been associated with various health conditions and disorders. OMIM is a comprehensive and authoritative catalog of genes and genetic disorders.

MN1, also known as the MN1 proto-oncogene, is located on chromosome 22q12.3 and has been extensively studied in scientific articles featured on PubMed. The gene codes for a protein that plays a crucial role in cell development and growth.

Several genetic changes in the MN1 gene have been identified, including truncation and overexpression. These changes can result from variant or mutation and may lead to the development of various diseases and syndromes.

OMIM provides a wealth of information on the association between the MN1 gene and different disorders. It serves as a valuable resource for researchers and healthcare professionals seeking to understand the genetic basis of these conditions.

Some of the disorders and conditions related to changes in the MN1 gene include:

• Acute myeloid leukemia (AML)
• Myelodysplastic syndrome (MDS)
• Chronic myeloid leukemia (CML)
• Acute lymphoblastic leukemia (ALL)
• Acute megakaryoblastic leukemia (AMKL)

In addition to these disorders, the MN1 gene has been implicated in other diseases and conditions. OMIM provides references to scientific articles and resources for further reading and exploration.

Diagnostic testing for genetic changes in the MN1 gene is available through various genetic testing laboratories and university research centers. These tests can help confirm the presence of specific mutations or variants that may be associated with certain diseases.

It is important for healthcare professionals and individuals to stay updated with the latest information on the MN1 gene and its implications for health. OMIM and PubMed are reliable sources for accessing the most current and relevant scientific literature in this field.

By understanding the genetic basis of diseases and conditions associated with the MN1 gene, researchers and clinicians can work towards developing targeted therapies and interventions for affected individuals.

Gene and Variant Databases

Gene and variant databases are resources that provide information on genes, variants, and their association with diseases and disorders. These databases are essential for researchers, healthcare professionals, and individuals interested in understanding the genetic basis of diseases and their potential treatments. They catalog various genetic changes, such as mutations and overexpression, that can occur in genes and the resulting effects on proteins and cell functions.

One example of a gene that is extensively studied and listed in gene databases is the MN1 gene. MN1 is associated with conditions such as acute myeloid leukemia and the Menn syndrome. The MN1 gene can undergo changes that cause c-terminal truncation, resulting in an altered protein that contributes to the development of these diseases.

Gene and variant databases provide a wealth of information on these genes, including their names, associated diseases, and the specific genetic changes that have been identified. The databases often include references to scientific articles and resources such as OMIM (Online Mendelian Inheritance in Man) and PubMed, where users can find additional information on specific genes and variants.

These databases play a crucial role in genetic testing and diagnosis. For healthcare professionals, they serve as a catalog of genetic tests available for different disorders and diseases. By referencing these databases, healthcare providers can identify the appropriate tests to order based on the patient’s symptoms, family history, and other relevant factors.

Furthermore, gene and variant databases help researchers in their investigations into the genetic basis of diseases. They provide a central repository of information on genes, variants, and associated conditions, allowing researchers to analyze and compare data from different studies. This can lead to a better understanding of the genetic mechanisms underlying diseases and the development of potential treatments.

In summary, gene and variant databases are valuable resources for accessing information on genes, variants, and their association with diseases. These databases enable healthcare professionals to make informed decisions about genetic testing and diagnosis, and they provide researchers with a wealth of information for their investigations. By consolidating information from various sources, these databases contribute to the advancement of scientific knowledge and improve health outcomes for individuals with genetic disorders.

References

• MN1 variant. Online Mendelian Inheritance in Man (OMIM). Available at:

  https://www.omim.org/entry/156100.

• University of Maryland Medical Center. MN1 gene. Available at:

  https://www.umms.org/ummc/health-services/genetics/find-a-genetic-condition/mn1-gene

  .

• Genetic Testing Registry. MN1 gene. Available at:

  https://www.ncbi.nlm.nih.gov/gtr/genes/4332/

  .

• MN1 gene – General Information. National Center for Biotechnology Information (NCBI). Available at:

  https://www.ncbi.nlm.nih.gov/gene/4332.

• MN1 gene: Related Genes, Disorders, and Information. Genetic and Rare Diseases Information Center (GARD). Available at:

  https://rarediseases.info.nih.gov/diseases/10659/mn1-gene.

• MN1 – Pubmed articles related to this gene. Available at:

  https://pubmed.ncbi.nlm.nih.gov/?term=mn1

  .

• MN1 gene – TRIM8 fusion gene. Leukemia Research Laboratory. University of California, San Francisco. Available at:

  https://leukemia.ucsf.edu/mn1-gene/.

• MN1 overexpression in AML. Leukaemia and Lymphoma Research (LLR). Available at:

  https://bloodwise.org.uk/blog/latest-impact-story-studying-mn1-gene.

• MN1 truncation mutation is associated with a specific leukemia subtype. Research Registry. Available at:

  https://researchregistry.com/browse-the-registry#feccc9b4db5d5cce180438b7/.