Risankizumab-rzaa Injection
Risankizumab-rzaa injection is used to treat moderate to severe plaque psoriasis (a skin disease in which red, scaly patches form on some areas of the body) in adults whose psoriasis is too severe to be treated by topical medications alone. It is also used to treat active psoriatic arthritis (condition that causes joint pain and swelling and scales on the skin) in adults. Risankizumab-rzaa injection is also used to treat Crohn’s disease (a condition in which the body attacks the lining of the digestive tract, causing pain, diarrhea, weight loss, and fever) in adults. Risankizumab-rzaa is in a class of medications called monoclonal antibodies. It works by stopping the action of certain cells in the body that cause the symptoms of psoriasis.
🔔 How should this medicine be used?
Risankizumab-rzaa comes as a solution (liquid) in a prefilled syringe, in a prefilled pen, as an on-body injector with a prefilled cartridge to inject subcutaneously (just under the skin), and as a solution to inject intravenously (into a vein). For the treatment of plaque psoriasis and psoriatic arthritis, it is usually given subcutaneously, using a prefilled syringe or prefilled pen as two injections for the first dose, followed by two injections 4 weeks after the first dose, and then two injections every 12 weeks. For the treatment of Crohn’s disease, risankizumab-rzaa is initially given intravenously over at least 60 minutes once every 4 weeks for the first 3 doses (at week 0, week 4, and week 8) by a doctor or nurse in a healthcare facility. After the first 3 doses, it is usually given subcutaneously using the on-body injector with a prefilled cartridge once every 8 weeks. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use risankizumab-rzaa injection exactly as directed. Do not inject more or less of it or inject it more often than prescribed by your doctor.
You may receive your first subcutaneous dose of risankizumab-rzaa injection in your doctor’s office. After your first dose, your doctor may allow you or a caregiver to perform the injections at home. Carefully read the manufacturer’s instructions for use that comes with the medication. These instructions describe how to inject a dose of risankizumab-rzaa injection. Be sure to ask your doctor or pharmacist if you have any questions about how to inject the medication.
You can inject risankizumab-rzaa injection anywhere on the front of your thighs (upper leg) or abdomen (stomach) except your navel and the area 2 inches (5 centimeters) around it. If someone else is giving you the injection using the syringe or pen, that person can also inject the medication into your upper, outer arms. Use a different site for each injection to reduce the chances of soreness or redness. Do not inject into an area where the skin is tender, bruised, red, or hard or where you have scars or stretch marks.
Do not shake a syringe, pen, on-body injector, or prefilled cartridge that contains risankizumab-rzaa.
Remove the carton containing the medication from the refrigerator and place it on a flat surface; do not remove the prefilled syringe, prefilled pen, or on-body injector with prefilled cartridge from the carton. Allow it to warm to room temperature (15 to 30 minutes for the prefilled syringe, 30 to 90 minutes for the prefilled pen, and 45 to 90 minutes for the prefilled automatic injection device) before you are ready to inject the medication. Do not remove the needle cover from the syringe or the needle cap from the prefilled pen until you are ready to inject the medication.
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Always look at risankizumab-rzaa solution before injecting it. Check that the expiration date has not passed and that the liquid is colorless to slightly yellow and clear. The liquid should not contain visible particles. Do not use a syringe, pen, or prefilled cartridge if it is cracked or broken, if it has been dropped, if it is expired, or if the liquid is cloudy or contains large or colored particles.
Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with risankizumab-rzaa injection. Read the information carefully and ask your doctor or pharmacist if you have any questions.
