Semaglutide

Semaglutide may increase the risk that you will develop tumors of the thyroid gland, including medullary thyroid carcinoma (MTC; a type of thyroid cancer). Laboratory animals who were given semaglutide developed tumors, but it is not known if this medication increases the risk of tumors in humans. Tell your doctor if you or anyone in your family has or has ever had MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2; condition that causes tumors in more than one gland in the body). If so, your doctor will probably tell you not to take semaglutide. If you experience any of the following symptoms, call your doctor immediately: a lump or swelling in the neck, hoarseness, difficulty swallowing, or shortness of breath.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests to check your body’s response to semaglutide.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with semaglutide tablets and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer’s website to obtain the Medication Guide.

Talk to your doctor about the risks of taking semaglutide.

🔔 Why is this medication prescribed?

Semaglutide is used along with a diet and exercise program to control blood sugar levels in adults with type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood). Semaglutide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated). Semaglutide is in a class of medications called incretin mimetics. It works by helping the pancreas to release the right amount of insulin when blood sugar levels are high. Insulin helps move sugar from the blood into other body tissues where it is used for energy. Semaglutide also works by slowing the movement of food through the stomach.

Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

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🔔 How should this medicine be used?

Semaglutide comes as a tablet to take by mouth. It is usually taken on an empty stomach once a day when you wake up. Take semaglutide with a sip of water (no more than 4 ounces [120 mL]) at least 30 minutes before eating a meal or snack, drinking, or taking any other medications. The drug works best if you eat a meal or snack 30 minutes after you take the drug. Your doctor may gradually increase your dose, depending on your response to semaglutide. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take semaglutide exactly as directed. Do not take more or less of it or take it more often than directed by the package label or prescribed by your doctor.

Swallow the tablets whole; do not split, chew, or crush them.

Semaglutide controls diabetes but does not cure it. Continue to take semaglutide even if you feel well. Do not stop taking semaglutide without talking with your doctor.