Sirolimus (with albumin) Injection

Sirolimus (with albumin) injection is used to treat a certain type of epithelioid cell tumor (soft tissue cancer that can form in any part of the body) that has spread to nearby tissues or to other parts of the body or can not be removed by surgery. Sirolimus is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that tells the cancer cells to multiply. This may help slow the growth of tumors.

🔔 How should this medicine be used?

Sirolimus (with albumin) injection comes as a suspension (liquid) to be given by intravenous infusion (slow injection into a vein) over 30 minutes. It is usually given by a doctor or nurse in a doctor’s office or infusion center. Sirolimus (with albumin) injection is usually given on days 1 and 8 of a 21 day cycle.

Your doctor may need to interrupt your treatment, reduce your dose, or stop your treatment depending on your response to the medication and any side effects that you experience. Be sure to tell your doctor how you are feeling during your treatment.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

🔔 Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

🔔 What special precautions should I follow?

Before receiving sirolimus (with albumin) injection,

• tell your doctor and pharmacist if you are allergic to sirolimus (Fyarro, Rapamune), other rapamycin derivatives such as everolimus (Afinitor, Zortress) or temsirolimus (Torisel), any other medications, or any of the ingredients in sirolimus (with albumin) injection. Ask your pharmacist for a list of the ingredients.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: boceprevir, bromocriptine, carbamazepine, cimetidine, cisapride, clarithromycin, clotrimazole, cyclosporine, danazol, diltiazem, erythromycin, indinavir, itraconazole, ketoconazole, metoclopramide, nicardipine, phenobarbital, phenytoin, rifabutin, rifampin, rifapentine, ritonavir, telaprevir, telithromycin, troleandomycin, verapamil, or voriconazole. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with sirolimus (with albumin) injection, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
• tell your doctor what herbal products you are taking, especially St. John’s wort.
• tell your doctor if you have or have ever had diabetes, high cholesterol, high levels of potassium in your blood, or liver or kidney problems.
• you should know that sirolimus (with albumin) injection may interfere with sperm production in men. However, you should not assume that you cannot get someone else pregnant. Tell your doctor if you are pregnant or plan to become pregnant. Your doctor may perform a pregnancy test to be sure that you are not pregnant when you begin receiving sirolimus (with albumin) injection. Use a reliable method of birth control to prevent pregnancy during your treatment with sirolimus (with albumin) injection and for 3 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while receiving sirolimus (with albumin) injection, call your doctor. Sirolimus (with albumin) injection may harm the fetus.
• if you have diabetes, you should know that sirolimus (with albumin) injection may increase glucose levels. Your doctor may ask you to monitor your blood glucose more frequently during your treatment with (with albumin) injection.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving sirolimus (with albumin) injection.
• do not have any vaccinations without talking to your doctor.

🔔 What special dietary instructions should I follow?

Do not eat large amounts of grapefruit or drink grapefruit juice while receiving this medication.

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