Sofosbuvir, Velpatasvir, and Voxilaprevir

You may already be infected with hepatitis B (a virus that infects the liver and may cause severe liver damage), but not have any symptoms of the disease. In this case, taking the combination of sofosbuvir, velpatasvir, and voxilaprevir may increase the risk that your infection will become more serious or life-threatening and you will develop symptoms. Tell your doctor if you have or ever had a hepatitis B virus infection. Your doctor will order a blood test to see if you have or have ever had hepatitis B infection. Your doctor will also monitor you for signs of hepatitis B infection during and for several months after your treatment. If necessary, your doctor may give you medication to treat this infection before and during your treatment with the combination of sofosbuvir, velpatasvir, and voxilaprevir. If you experience any of the following symptoms during or after your treatment, call your doctor immediately: excessive tiredness, yellowing of the skin or eyes, loss of appetite, nausea or vomiting, pale stools, pain in upper right side of the stomach area, or dark urine.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests before, during, and after your treatment to check your body’s response to the combination of sofosbuvir, velpatasvir, and voxilaprevir.

Talk to your doctor about the risk(s) of taking sofosbuvir, velpatasvir, and voxilaprevir.

🔔 Why is this medication prescribed?

The combination of sofosbuvir, velpatasvir, and voxilaprevir is used to treat chronic (long-term) hepatitis C infection (swelling of the liver caused by a virus) in adults who have already received other HCV treatments. Sofosbuvir is a non-nucleoside NS5B polymerase inhibitor. It works by decreasing the amount of hepatitis C virus in the body. Velpatasvir is a hepatitis C virus (HCV) NS5A inhibitor. It works by stopping the virus that causes hepatitis C from spreading inside the body. Voxilaprevir is in a class of medications called HCV NS3/4A protease inhibitors. It works by decreasing the amount of HCV in the body.

🔔 How should this medicine be used?

The combination of sofosbuvir, velpatasvir, and voxilaprevir comes as a tablet to take by mouth. It is usually taken with food once daily for 12 weeks. Take sofosbuvir, velpatasvir, and voxilaprevir at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sofosbuvir, velpatasvir, and voxilaprevir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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Continue to take sofosbuvir, velpatasvir, and voxilaprevir even if you feel well. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking sofosbuvir, velpatasvir, and voxilaprevir without talking to your doctor.

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Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

🔔 Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.