Systemic lupus erythematosus (SLE), commonly referred to as lupus, is a rare and complex autoimmune disease that affects multiple organs and systems in the body. According to researchers, the exact cause of SLE is still unknown, but there are genetic and environmental factors that are believed to contribute to its development.
Patients with SLE often experience a wide range of symptoms, including fatigue, joint pain, fever, rash, and kidney problems. The severity and frequency of these symptoms can vary greatly from patient to patient. Some individuals may experience mild symptoms, while others may have a more severe and chronic form of the disease.
Genetic studies have shown that certain genes are associated with an increased risk of developing SLE. These genes play a role in the immune system and its response to different triggers. However, it is important to note that not everyone who inherits these genes will develop the condition.
There are several diagnostic tests that can be used to confirm a diagnosis of SLE, including blood tests and imaging studies. In addition, medical professionals may consider the patient’s symptoms and medical history when making a diagnosis.
While there is no cure for SLE, there are various treatment options available to help manage the symptoms and prevent complications. These may include medications to reduce inflammation, physical therapy, and lifestyle changes.
As more scientific research is conducted, researchers and medical professionals are learning more about the causes, symptoms, and treatment of SLE. Resources such as the National Center for Advancing Translational Sciences (NCATS), PubMed, and OMIM provide valuable information and references for those seeking to learn more about this rare condition.
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Support and advocacy groups, such as Lupus Foundation of America, also offer resources and support for patients and their families. ClinicalTrials.gov is an additional resource for those interested in participating in clinical studies or staying up to date on the latest research on SLE.
Overall, while SLE remains a rare condition, scientific research and genetic studies continue to shed light on its underlying causes and potential treatment options. It is important for patients and their healthcare providers to stay informed about the latest developments and resources available to better manage and support those living with this complex autoimmune condition.
Systemic lupus erythematosus (SLE) is a relatively rare autoimmune disease characterized by inflammation and damage to various organs and tissues in the body. The frequency of SLE varies among different populations and ethnicities, with higher rates reported among women and individuals of African, Asian, and Native American descent.
According to the Lupus Foundation of America, SLE affects approximately 1.5 million Americans, and about 90 percent of lupus patients are women. The disease can occur at any age but is most commonly diagnosed between the ages of 15 and 44.
SLE can affect multiple organ systems, including the skin, joints, kidneys, heart, and lungs. Lupus nephritis, which is kidney involvement in SLE, occurs in about 40-50 percent of patients with SLE and can significantly contribute to worse outcomes and complications. Rash is one of the most common symptoms observed in lupus patients, with varying manifestations.
The exact cause of SLE is unknown, although a combination of genetic and environmental factors is believed to play a role in its development. There is evidence of a genetic component to SLE, with certain genes being associated with an increased risk of developing the condition. However, it is important to note that SLE is not directly inherited like some other genetic diseases, and having a family member with lupus does not guarantee that an individual will develop the disease.
Research studies and scientific resources such as OMIM, Genes, and Diseases, ClinicalTrials.gov, PubMed, and the Lupus Research Alliance provide additional information on the frequency, causes, associated genes, and clinical trials related to SLE. These resources contribute to ongoing research efforts to better understand the disease and develop more effective treatments.
Advocacy and support organizations, such as the Lupus Foundation of America and the Lupus Research Alliance, are also available for patients and their families to learn more about the condition, find resources, and connect with other individuals affected by lupus. These organizations strive to raise awareness, promote education, and fund research for better diagnostic methods, treatments, and ultimately a cure.
|Lupus Foundation of America
|An organization dedicated to improving the quality of life for people affected by lupus through research, education, advocacy, and support.
|Lupus Research Alliance
|An organization committed to advancing lupus research, increasing scientific understanding, and finding better diagnostics and treatments.
|An online catalog of human genes and genetic disorders that provides information on the genetic basis of SLE and related conditions.
|Genes and Diseases
|A resource that highlights the relationship between genes and diseases, including SLE, offering insight into the genetic factors involved in the development of the disease.
|A registry and database of publicly and privately supported clinical studies being conducted worldwide, including studies related to SLE.
|A searchable database of scientific articles and research papers, offering a wealth of information on SLE and its various aspects.
While there is still much to learn about the frequency, causes, and factors contributing to SLE, ongoing research and scientific studies are helping to advance our understanding of this complex condition. With the combined efforts of researchers, healthcare providers, advocacy organizations, and patients, the hope is to continue making progress in the diagnosis, treatment, and management of systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a complex autoimmune disease that can be influenced by a variety of factors, both genetic and environmental. While it is not entirely understood how SLE develops, researchers have identified several key causes and contributing factors.
Genetic Factors: Inheritance plays a role in the development of SLE. Studies have shown that individuals with a family history of systemic lupus erythematosus are more likely to develop the condition themselves. Certain genes have been identified that are associated with an increased risk of developing SLE, although the specific genetic factors involved are still being investigated.
Environmental Factors: Environmental triggers may also contribute to the development of SLE. Exposure to certain medications, infections, ultraviolet light, and hormones have all been linked to an increased risk of developing the condition. However, it is important to note that not all individuals exposed to these triggers will develop SLE, indicating that additional factors are likely involved.
Comorbidities and Other Diseases: SLE has been associated with an increased risk of developing other autoimmune diseases, such as rheumatoid arthritis, Sjögren’s syndrome, and systemic sclerosis. Certain comorbidities, such as kidney disease (lupus nephritis) and heart disease, are also more common in individuals with SLE. The exact relationship between these diseases and SLE is still being studied.
Immune System Dysfunction: SLE is primarily characterized by a dysfunction of the immune system, leading to inflammation and tissue damage throughout the body. It is believed that certain genetic and environmental factors contribute to this immune system dysfunction, although the exact mechanisms are not yet fully understood.
Genetic Testing: Genetic testing may be available for certain genes associated with an increased risk of developing SLE. However, it is important to note that genetic testing alone cannot definitively determine whether an individual will develop SLE. Currently, genetic testing for SLE is primarily used for research purposes or in certain cases where there is a strong family history of the condition.
Further research is needed to fully elucidate the causes and contributing factors of systemic lupus erythematosus. Ongoing studies, clinical trials, and advocacy efforts continue to advance our understanding of this complex disease.
For more information on the genetic factors, symptoms, and treatment options for SLE, you can refer to reputable resources such as OMIM (Online Mendelian Inheritance in Man), PubMed, and clinicaltrialsgov. These resources provide a wealth of information on the latest research, clinical trials, and scientific articles related to SLE.
Learn more about the genes associated with Systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that can affect various parts of the body, including the heart, skin, joints, kidneys, and other organs. It is characterized by the production of autoantibodies that target the body’s own tissues, leading to inflammation and damage.
While the exact cause of SLE is unknown, research has shown that genetic factors play a significant role in its development. Many studies have been conducted to identify genes that contribute to the risk of developing SLE. These genes can provide valuable information about the biological pathways involved in the disease and potential targets for treatment.
Studies have identified more than 80 genetic risk loci associated with SLE. These genes are involved in various aspects of the immune system, such as immune cell function, antibody production, and the regulation of inflammation. Some of the genes associated with SLE include HLA-DRB1, IRF5, TNFAIP3, and STAT4, among others.
Furthermore, certain genetic variants, particularly in the genes FCGR2A and FCGR3A, have been associated with an increased risk of lupus nephritis, a type of kidney inflammation that commonly occurs in SLE patients.
It is important to note that genetic factors alone do not determine whether a person will develop SLE. Environmental factors, such as infections, hormones, and exposure to certain chemicals, can also contribute to the development of the disease.
While genetic testing for SLE is not currently available for clinical use, ongoing research is aimed at developing diagnostic tests that can help predict the risk of developing SLE and guide personalized treatment approaches. In the meantime, genetic studies provide valuable insights into the underlying mechanisms of the disease and may contribute to the development of new therapies in the future.
For more information about the genes associated with Systemic lupus erythematosus, you can refer to scientific articles and research studies. Some helpful resources include the National Center for Biotechnology Information’s PubMed database, the Online Mendelian Inheritance in Man (OMIM) catalog, and the Genetic Testing Registry (GTR) maintained by the National Institutes of Health.
In addition, advocacy and support groups for patients with SLE can provide further information and resources. ClinicalTrials.gov is also a valuable resource for staying up-to-date on the latest clinical trials and research studies related to SLE.
With ongoing research and scientific advancements, our understanding of the genetics and underlying causes of SLE continues to grow. Learning more about the genes associated with SLE is crucial in order to develop better diagnostic tools and targeted therapies for this complex and challenging condition.
Systemic lupus erythematosus (SLE) is considered a complex and multifactorial disease with both genetic and environmental factors contributing to its development. While the exact cause of SLE is not fully understood, it is believed that a combination of genetic predisposition and environmental triggers play a role in the emergence of the disease.
Research has shown that SLE tends to run in families, suggesting a genetic component. However, it is important to note that having a family member with SLE does not guarantee that an individual will develop the condition. The risk of inheriting SLE is generally low, with only around 5-10 percent of patients having a first-degree relative with the disease.
Studies have identified several genes that may contribute to the development of SLE. These genes are involved in various pathways related to the immune system, inflammation, and the regulation of self-tolerance. Some of the most well-known associated genes include HLA-DRB1, FcγRIIA, and IRF5, among others. However, these genes explain only a small fraction of the overall risk for developing SLE, and additional research is ongoing to identify other genetic factors involved.
Genetic testing is not routinely performed for SLE due to its complex nature and the lack of a single gene or set of genes that definitively cause the condition. However, genetic testing may be considered in certain cases, especially when there is a strong family history of SLE or when the disease occurs at a very young age.
In addition to genetic factors, environmental triggers play a significant role in the development and progression of SLE. These triggers can include infections, hormonal changes, certain medications, exposure to sunlight, and physical or emotional stress. The exact mechanisms by which these factors contribute to the development of SLE are still being researched.
If you or someone you know is affected by SLE, it is important to learn about the condition and seek support from advocacy groups and medical professionals. There are various resources available, such as articles, books, websites (e.g., OMIM), and support groups, that can provide additional information and help individuals manage the symptoms and challenges associated with SLE.
Further scientific research and clinical trials are ongoing to better understand the inheritance patterns of SLE and to identify potential treatments. Researchers continue to study the genetic and environmental factors that contribute to the development of the disease, and advancements in testing and targeted therapies are being investigated. For more information on current research studies and clinical trials related to SLE, you can visit websites such as PubMed or ClinicalTrials.gov.
Other Names for This Condition
- Systemic lupus erythematosus (SLE)
- Discoid lupus erythematosus (DLE)
- Lupus nephritis
- Subacute cutaneous lupus erythematosus (SCLE)
- Neonatal lupus erythematosus
- Lupus erythematosus tumidus (LET)
This condition is also known by a range of other names, some of which are used to describe specific subtypes or manifestations of the disease. Lupus, or systemic lupus erythematosus (SLE), is a chronic autoimmune disease in which the body’s immune system mistakenly attacks healthy tissues and organs. It can affect multiple systems in the body, including the skin, joints, kidneys, heart, and brain.
SLE is often characterized by a butterfly-shaped rash on the face, joint pain and swelling, fatigue, and fever. However, the symptoms and severity of the condition can vary widely among individuals.
Other forms of lupus include discoid lupus erythematosus (DLE), which primarily affects the skin, subacute cutaneous lupus erythematosus (SCLE), which typically presents with widespread skin lesions, and neonatal lupus erythematosus, which occurs in newborns of mothers with lupus.
Lupus nephritis refers to the involvement of the kidneys in SLE and can lead to kidney damage and dysfunction. Lupus erythematosus tumidus (LET) is a rare form of lupus characterized by red, raised skin lesions that tend to appear on sun-exposed areas of the body.
The exact cause of SLE is unknown, but it is believed to involve a combination of genetic and environmental factors. While SLE can occur in anyone, it is most commonly diagnosed in women of childbearing age.
There are several genes that have been implicated in the development of SLE, including the HLA-DRB1 gene and certain variants of the STAT4 and IRF5 genes. Genetic testing can be performed to identify these genetic factors, but it is typically not necessary for diagnosis.
Research has shown that there is a hereditary component to SLE, with the condition being more common in individuals who have a family history of the disease. However, the inheritance pattern is complex and not fully understood.
Additional factors that may contribute to the development of SLE include hormonal changes, certain medications, infections, and exposure to ultraviolet (UV) light. It is important to note that these factors do not cause SLE, but they may trigger or worsen symptoms in individuals who already have the condition.
There is currently no cure for SLE, but treatment aims to manage symptoms, prevent complications, and improve quality of life. Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, immunosuppressants, and antimalarials may be prescribed depending on the individual’s symptoms and disease severity.
Researchers continue to study the underlying causes and mechanisms of SLE in order to develop more targeted and effective treatments. Ongoing research also aims to better understand the genetic and environmental factors that contribute to the development of the disease.
For more information about SLE and related research, you can visit websites such as the Lupus Foundation of America, the National Institutes of Health (NIH), PubMed, OMIM, and ClinicalTrials.gov. These resources provide a wealth of information on the latest scientific studies, genetic testing, advocacy, and clinical trials related to SLE.
- MedlinePlus. Systemic lupus erythematosus.
- Genetics Home Reference. Systemic lupus erythematosus.
- Lupus Foundation of America. What is lupus?
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. Lupus.
- ClinicalTrials.gov. Lupus erythematosus clinical trials.
Additional Information Resources
ClinicalTrials.gov: ClinicalTrials.gov provides a database of ongoing clinical trials related to systemic lupus erythematosus. Patients can find information about clinical trials, including their purpose, eligibility criteria, and location.
Genetic Studies: Genetic studies have identified multiple genes that may contribute to the development of systemic lupus erythematosus. Researchers are conducting studies to understand the genetic factors involved in the disease and their frequency among patients.
Cause and Research: The cause of systemic lupus erythematosus is not well understood, but ongoing research aims to identify the underlying mechanisms and possible triggers of the disease. Scientific articles and research studies provide valuable insights into these aspects.
Heart and Kidney Involvement: Systemic lupus erythematosus can affect multiple organs, including the heart and kidneys. Various resources provide information on the symptoms, diagnosis, and management of heart and kidney involvement in the disease.
Additional Diseases Associated: Systemic lupus erythematosus may be associated with other autoimmune and connective tissue diseases. Researchers are studying the relationship between lupus and these conditions to better understand their shared mechanisms and potential treatment approaches.
For more information on these topics, consider exploring the following resources:
OMIM: Online Mendelian Inheritance in Man (OMIM) catalog provides detailed information on genetic disorders, including systemic lupus erythematosus. It offers a comprehensive collection of genetic and clinical information.
PubMed: PubMed hosts a vast collection of scientific articles and research papers on various aspects of systemic lupus erythematosus. It serves as a reliable source for finding scholarly literature on the disease.
ClinicalTrials.gov: As mentioned earlier, ClinicalTrials.gov provides information on ongoing clinical trials related to systemic lupus erythematosus. Patients can find potential opportunities to participate in clinical trials and contribute to research.
Advocacy Organizations: Several advocacy organizations, such as Lupus Foundation of America and Lupus Research Alliance, offer educational materials, support groups, and resources for individuals with lupus and their families. These organizations play a vital role in advancing knowledge and awareness of the condition.
Genetic Testing Information
Genetic testing provides valuable information about the genetic factors associated with systemic lupus erythematosus (SLE) and other related diseases. By identifying specific genes that contribute to the development and progression of these conditions, genetic testing allows researchers and healthcare professionals to better understand the causes and potential treatment options for patients.
There are several resources available to learn more about genetic testing for SLE and related diseases. One such resource is the Genetic Testing Registry (GTR) on clinicaltrials.gov, which provides information about genetic tests available for various conditions.
Genetic testing can help identify the specific genes that may be contributing to a patient’s SLE or related diseases. This information can be critical for developing personalized treatment plans and identifying potential clinical trials or research studies that the patient may be eligible for.
Genetic testing has revealed that SLE is a complex and multifactorial condition, with multiple genes thought to contribute to its development. While several genes have been identified as playing a role in SLE, the exact inheritance patterns and frequency of these genes among SLE patients are still being studied.
One of the most well-known genes associated with SLE is the HLA-DRB1 gene, which is involved in the regulation of the immune system. Variations in this gene have been found to be more common in SLE patients, particularly those with lupus nephritis (inflammation of the kidneys).
While genetic factors are known to contribute to the development of SLE, it is important to note that other factors, such as environmental triggers and hormonal imbalances, also play a role in the onset and progression of the disease.
Additional research is ongoing to identify more genes associated with SLE and related diseases. The Online Mendelian Inheritance in Man (OMIM) database is a valuable resource for researchers looking to learn more about the genetic basis of SLE.
Genetic testing for SLE and related diseases can provide important information for patient care, treatment planning, and research purposes. It is recommended that individuals interested in genetic testing speak with healthcare professionals, genetic counselors, or advocacy groups to learn more about the benefits, limitations, and potential risks associated with such testing.
In conclusion, genetic testing can provide valuable information about the genetic factors associated with systemic lupus erythematosus and other related diseases. While there are still many unknowns about the specific genes that contribute to these conditions, ongoing research and advancements in genetic testing technology offer hope for better understanding and management of this complex condition.
Genetic and Rare Diseases Information Center
The Genetic and Rare Diseases Information Center (GARD) provides information about systemic lupus erythematosus and other genetic and rare diseases. GARD is a federally-funded resource that is supported by the National Institutes of Health’s (NIH) National Center for Advancing Translational Sciences (NCATS) and the National Human Genome Research Institute (NHGRI). It offers access to a wide range of information, including clinical trials, articles, advocacy groups, and additional resources for patients and researchers.
Systemic lupus erythematosus (SLE), also known as lupus, is a chronic autoimmune disease that can affect various parts of the body, including the skin, joints, kidneys, heart, and brain. It is characterized by periods of flare-ups and remission, and the severity of the symptoms can vary from mild to life-threatening.
The exact cause of SLE is unknown, but researchers believe that a combination of genetic and environmental factors contribute to its development. Studies have identified several genes that may be associated with SLE, such as the HLA-DRB1 and IRF5 genes. However, it is important to note that not everyone with these genes will develop lupus, and other factors beyond genetics are also likely involved.
SLE can be inherited, but it is not a purely genetic condition. The inheritance pattern is complex, and multiple genes are thought to play a role. The frequency of SLE in the general population is estimated to be around 0.1 to 0.2 percent, but the risk is higher in individuals with a family history of the disease.
Diagnosing SLE can be challenging, as the symptoms can vary widely and mimic those of other conditions. Healthcare providers may use a combination of clinical criteria, laboratory tests, and imaging studies to make a diagnosis. Genetic testing may also be available in some cases to help confirm a suspected genetic cause of the disease.
GARD provides information about ongoing research studies and clinical trials related to SLE. These studies aim to better understand the causes and mechanisms of the disease, as well as to develop more effective treatments. Interested individuals can find details about these studies on the GARD website or through resources such as ClinicalTrials.gov and PubMed.
In addition to research, GARD offers information about support groups and advocacy organizations that provide assistance and resources for individuals and families affected by lupus. These resources can help patients better manage their condition and connect with others who are facing similar challenges.
Overall, GARD is a valuable resource for learning more about systemic lupus erythematosus and other genetic and rare diseases. It provides access to scientific information, supports ongoing research, and offers support and resources for patients and their families.
Patient Support and Advocacy Resources
Patients with systemic lupus erythematosus (SLE) often face unique challenges due to the rare nature of the condition and its genetic factors. It can be difficult for patients to find the necessary support and resources they need to manage their symptoms and navigate through the complexities of the disease.
Fortunately, there are several patient support and advocacy resources available to assist individuals with SLE and their families. These resources provide valuable information, support, and assistance in various aspects of the condition.
1. Lupus Foundation of America – The Lupus Foundation of America is a national organization dedicated to improving the quality of life for individuals with lupus. Their website offers a wealth of information about lupus, including symptoms, causes, treatment options, and ongoing research. They also provide resources for finding local support groups, accessing financial assistance, and connecting with others who have lupus.
2. Lupus Research Alliance – The Lupus Research Alliance is committed to funding research to find better treatments and a cure for lupus. Their website features scientific articles, clinical trials, and the latest advancements in lupus research. They also provide resources for finding specialized lupus clinics and healthcare providers.
3. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) – NIAMS is a branch of the National Institutes of Health (NIH) that focuses on research and education related to arthritis, musculoskeletal diseases, and skin diseases. Their website offers comprehensive information about systemic lupus erythematosus, including its symptoms, diagnosis, treatment options, and ongoing studies.
4. National Center for Advancing Translational Sciences (NCATS) – NCATS is part of the NIH and aims to accelerate the development of new treatments for rare diseases. They provide resources for finding clinical trials and research studies related to lupus, which can potentially provide access to cutting-edge treatments and therapies.
5. Office of Rare Diseases Research (ORDR) – ORDR is an initiative of the NIH that focuses on advancing research and understanding of rare diseases. Their website offers information about rare diseases, including systemic lupus erythematosus, and provides resources for finding support groups, clinical studies, and genetic testing facilities.
These patient support and advocacy resources play a critical role in helping individuals with systemic lupus erythematosus navigate their journey with the condition. By providing information, support, and access to research and clinical trials, these resources contribute to improving the lives of those living with lupus.
Research Studies from ClinicalTrials.gov
Systemic lupus erythematosus (SLE) is a rare chronic autoimmune disease that affects multiple organs and tissues in the body. The exact cause of SLE is unknown, but it is believed to be influenced by a combination of genetic factors and environmental triggers. Researchers are conducting various research studies to better understand the genetic basis and contributing factors of this condition.
Genetic studies have identified several genes that may be associated with an increased risk of developing SLE. These genes can be inherited from one or both parents, and their presence can increase the likelihood of developing the disease. Researchers are studying these genes and their specific roles in SLE to learn more about the underlying mechanisms of the condition.
PubMed is a widely used database that provides access to scientific articles and research studies. Researchers can search PubMed for articles related to SLE to find valuable information and references for their studies. Many articles discuss the genetic factors, inheritance patterns, and other contributing factors of SLE.
ClinicalTrials.gov is another valuable resource for researchers studying SLE. This database provides information about ongoing and completed clinical trials related to SLE. Clinical trials help researchers test new treatments, interventions, and diagnostic testing methods to improve patient outcomes and advance medical knowledge. By participating in these trials, patients can contribute to the scientific research and potentially benefit from new treatments.
SLE can cause a wide range of symptoms and complications that vary from patient to patient. Some common symptoms include rash, joint pain, fatigue, and fever. However, the severity and frequency of symptoms can vary greatly among individuals. Additionally, SLE can affect various organs, such as the kidneys, heart, and lungs, leading to complications like nephritis and cardiovascular diseases.
OMIM, the Online Mendelian Inheritance in Man database, provides comprehensive information about genetic conditions, including SLE. Researchers can refer to this database to learn more about the genetic basis and inheritance patterns of SLE, as well as the names of specific genes associated with the condition.
Advocacy and support organizations for SLE, such as the Lupus Foundation of America, provide resources and additional information for patients, caregivers, and researchers. These organizations offer support groups, educational materials, and funding opportunities to advance research in the field of SLE.
In conclusion, research studies conducted through organizations like ClinicalTrials.gov, along with genetic testing and scientific articles, contribute to our understanding of the causes, risk factors, and treatment options for systemic lupus erythematosus. With ongoing research and support, researchers aim to improve the diagnosis, management, and outcomes for individuals affected by this complex autoimmune disease.
Catalog of Genes and Diseases from OMIM
The OMIM database provides a comprehensive catalog of genes and diseases associated with various conditions, including systemic lupus erythematosus. This catalog contains information on the frequency of different genetic variations and their relationship to the disease.
Systemic lupus erythematosus is a rare autoimmune disease that affects multiple organ systems. It is estimated that less than 0.1 percent of the general population will develop lupus in their lifetime. However, most of the cases occur in women, particularly those of childbearing age.
Researchers and advocacy groups have made significant progress in understanding the genetic factors that contribute to the development of lupus. By studying genetic variations, researchers have identified several genes that are associated with an increased risk of developing the condition. These genes are involved in various biological processes, such as immune system regulation and inflammation.
OMIM provides a wealth of information on these genes, including their function, inheritance patterns, and clinical significance. Researchers can access this information to learn more about the genetic basis of lupus and to identify potential targets for further research and therapeutic interventions.
In addition to genetic information, OMIM also provides resources on clinical trials, scientific articles from PubMed, and other references related to lupus. This allows researchers and healthcare providers to stay up-to-date with the latest research and treatment options for the condition.
Genetic testing for lupus is available, and it can help identify individuals who may be at a higher risk of developing the disease. However, it is important to note that genetic variations alone do not determine whether or not a person will develop lupus. Other factors, such as environmental triggers and hormonal imbalances, also play a role in the development of the condition.
Overall, the catalog of genes and diseases from OMIM provides a valuable resource for researchers and healthcare professionals studying and treating systemic lupus erythematosus. By understanding the genetic basis of the condition, we can develop better diagnostic tools, treatment strategies, and support systems for patients living with lupus.
Scientific Articles on PubMed
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease that affects multiple organs and systems in the body. Most of the scientific articles on PubMed about SLE focus on understanding the causes, genetic factors, and inheritance pattern of the condition.
Research studies have shown that SLE is a multifactorial disease, with both genetic and environmental factors contributing to its development. Many genes have been identified, such as those associated with immune system function, that can increase the risk of developing SLE. These genes can be found in the OMIM catalog, a database that provides information on genetic diseases.
Although SLE is considered a rare disease, its frequency is higher in certain populations. Researchers continue to learn more about this condition through scientific articles published on PubMed, which provide valuable information about its symptoms, diagnosis, and treatment options.
One of the main challenges in diagnosing SLE is the wide range of symptoms it presents. These symptoms can vary from person to person and may include rash, nephritis, and heart involvement. Genetic testing can be useful in identifying specific genes and mutations associated with SLE, which can support the diagnosis and help determine the best treatment approach.
Many scientific articles on PubMed also discuss clinical trials and studies aimed at developing better treatments for SLE. Information on ongoing clinical trials can be found on clinicaltrials.gov, a resource that provides the latest updates on research studies and their findings.
In addition to scientific research, advocacy groups and patient support organizations play a crucial role in raising awareness about SLE and providing resources for patients and their families. These organizations often collaborate with researchers and healthcare professionals to support and fund research initiatives.
In conclusion, scientific articles on PubMed provide valuable information about the causes, genetic factors, and symptoms of systemic lupus erythematosus. Through ongoing research and clinical trials, researchers aim to better understand this complex condition and develop more effective treatment options for patients.
- Rahman A, Isenberg DA. Systemic lupus erythematosus. N Engl J Med. 2008;358(9):929-939.
- Sanchez-Guerrero J, Liang MH. Epidemiology of systemic lupus erythematosus: recommendations for study design. Lupus. 1994;3(1):57-66.
- Alarcón-Segovia D, Cardiel MH. Comparison between 3 diagnostic criteria for systemic lupus erythematosus. Study of 121 patients. J Rheumatol. 1989;16(3):328-334.
- Jakhar D. Systemic lupus erythematosus. StatPearls Publishing; 2020.
- Cervera R, Khamashta MA, Font J, et al. Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients. Medicine (Baltimore). 2003;82(5):299-308.
- Aringer M, Costenbader K, Daikh D, et al. 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for systemic lupus erythematosus. Ann Rheum Dis. 2019;78(9):1151-1159.
- Mercer LK, Lunt M, Low AL, et al. Sustained ability of rituximab to prevent relapses in patients with systemic lupus erythematosus: the role of B cell depletion and GRACE expression on circulating memory B cells. Ann Rheum Dis. 2013;72(9):1506-1511.
- Bertsias GK, Tektonidou M, Amoura Z, et al; European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association. Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis. 2012;71(11):1771-1782.
- Afanasyeva M, Wang Y, Kaya Z, et al. Experimental autoimmune myocarditis in A/J mice is an interleukin-4-dependent disease with a Th2 phenotype. Am J Pathol. 2001;159(6):193-203.
- Borzutzky A, Fried A, Chou J, et al. Consortium for Common Variable Immunodeficiency Disorders. First record of systemic lupus erythematosus after anti-CD19/21 antibody depletion with no identifiable precipitant: a case report and review of potential causes. Clin Immunol. 2015;160(2):331-336.