Tasimelteon

Tasimelteon is used to treat non-24-hour sleep-wake disorder (non-24; a condition that occurs mainly in people who are blind in which the body’s natural clock is out of sync with the normal day-night cycle and causes a disrupted sleep schedule) in adults. It is also used to treat nighttime sleep problems in adults and children 3 years of age and older with Smith-Magenis Syndrome (SMS; a developmental disorder). Tasimelteon is in a class of medications called melatonin receptor agonists. It works similarly to melatonin, a natural substance in the brain that is needed for sleep.

🔔 How should this medicine be used?

Tasimelteon comes as a capsule and as an suspension to take by mouth. It is usually taken without food once a day, 1 hour before bedtime. Take tasimelteon at the same time every night. If you or your child are unable to take tasimelteon around the same time on a given night, skip that dose and take the next dose as scheduled. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tasimelteon exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open, crush, or chew them.

If you or your child are taking the suspension, follow these steps to prepare and measure the dose:

1. Remove the tasimelteon bottle, bottle adapter, and oral dosing syringe from the carton.
2. Shake the bottle up and down for at least 30 seconds to mix the medication evenly before each administration.
3. Press down on the child-resistant cap and twist it counterclockwise to open the bottle; do not discard the cap.
4. Before you open the tasimelteon bottle for the first time, remove the seal from bottle and insert the press-in bottle adapter into the bottle. Press on the bottle adapter until it is even with the top of the bottle; after the bottle adapter is in place, do not remove it. Then, replace the cap by turning clockwise and shake well again for 30 seconds.
5. Push the plunger of the oral dosing syringe completely down. Insert the oral dosing syringe into the opening of the press-in bottle adapter as far as it will go.
6. With the oral dosing syringe in the bottle adapter, carefully turn the bottle upside down. Pull the plunger back to withdraw the amount of suspension prescribed by the doctor. If you are not sure how to correctly measure the dose, ask your doctor or pharmacist. If you see more than a few air bubbles in the oral dosing syringe, fully push in the plunger so that the liquid flows back into the bottle until the air bubbles are mostly gone.
7. Leave the oral dosing syringe in the bottle adapter and turn the bottle upright. Carefully remove the oral dosing syringe from the bottle adapter. Replace the child-resistant cap securely.
8. Remove the dosing dispenser and slowly squirt the suspension directly into your mouth or your child’s mouth and toward the inside of their cheek. Slowly push the plunger all the way in to give the entire dose. Make sure the child has time to swallow the medication.
9. Remove the plunger from the barrel of the oral dosing syringe. Rinse the oral dosing syringe barrel and plunger with water and when dry, put the plunger back into the oral dosing syringe. Do not wash the oral dosing syringe in the dishwasher.
10. Do not discard the oral dosing syringe. Always use the oral dosing syringe that comes with tasimelteon to measure your child’s dose.
11. Refrigerate the suspension after each use.

You may become sleepy soon after you take tasimelteon. After you take tasimelteon, you should complete any necessary bedtime preparations and go to bed. Do not plan any other activities for this time.

Tasimelteon controls certain sleep disorders, but does not cure them. It may take several weeks or months before you feel the full benefit of tasimelteon. Continue to take tasimelteon even if you feel well. Do not stop taking tasimelteon without talking to your doctor.

Tasimelteon is not available in pharmacies. You can only get tasimelteon through the mail from a specialty pharmacy. Ask your doctor if you have any questions about receiving your medication.

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Tasimelteon capsules and suspension may not be able to be substituted for one another. Ask your pharmacist if you have any questions about the type of tasimelteon product your doctor has prescribed.