Variant Call ANalysis (VCAN) gene, also known as versican, is a gene that plays a crucial role in various biological processes. It is involved in the control of cell adhesion, proliferation, and migration, as well as in the production of extracellular matrix proteins.

Within the genetic testing catalog, the VCAN gene is listed as a target for testing for various diseases and conditions. Many tests for gene changes in VCAN are available, with references to scientific articles, databases, and other resources for additional information.

One of the conditions associated with changes in the VCAN gene is Wagner syndrome, a rare genetic disorder that affects vision. The occurrence of changes in the VCAN gene is listed in the Online Mendelian Inheritance in Man (OMIM) database, along with related conditions.

Researchers and healthcare professionals can access the VCAN gene registry and find information on genetic testing, articles, and other resources to further understand the role of VCAN in different diseases and conditions.

Health Conditions Related to Genetic Changes

Genes are responsible for carrying the genetic information that controls various functions and traits in our bodies. Any changes or alterations in these genes can result in different health conditions. One such gene that has been extensively studied is the VCAN gene, also known as versican.

Versican is a protein that is encoded by the VCAN gene. It plays a crucial role in the production of extracellular matrix and helps regulate cell adhesion and migration. Genetic changes or variants within the VCAN gene have been associated with several health conditions.

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One of the health conditions related to genetic changes in the VCAN gene is Wagner syndrome. Wagner syndrome is a rare genetic disorder characterized by progressive loss of vision. It is caused by mutations in the VCAN gene, leading to abnormal production of versican proteins. These genetic changes affect the structure and function of the eye, resulting in vision problems.

Researchers have conducted numerous studies to understand the impacts of genetic changes in the VCAN gene on human health. Many scientific articles related to VCAN gene variations and their association with various diseases can be found in the PubMed database. These articles provide valuable information for researchers and healthcare professionals.

In addition to PubMed, there are other resources available for obtaining information on genetic changes in the VCAN gene and related health conditions. The Online Mendelian Inheritance in Man (OMIM) database provides detailed information on various genetic disorders, including those linked to the VCAN gene.

Genetic testing is an important tool in diagnosing health conditions caused by genetic changes. Testing for VCAN gene variants can help identify individuals at risk for conditions like Wagner syndrome. Genetic testing may also be recommended in cases where other similar health conditions occur, as VCAN gene changes may be involved.

Overall, understanding the health conditions related to genetic changes in the VCAN gene is crucial for researchers, healthcare professionals, and individuals seeking information about their genetic health. The VCAN gene plays a significant role in various diseases, and resources like PubMed and OMIM provide valuable references and scientific articles for further study.

Wagner syndrome

Wagner syndrome is a rare genetic condition that is characterized by changes in the VCAN gene, which codes for the production of versican, a protein found in the extracellular matrix of many tissues. This condition is listed in the OMIM database, a catalog of genetic diseases, as ID 143200.

Wagner syndrome is associated with changes in the VCAN gene, specifically a variant known as the c.6144+1G>A change. This change affects the production of versican, leading to abnormalities in the vitreous gel of the eye and causing vision problems. Theocharis et al. (2002) provide additional information about this variant in their article published in the journal “Vision Research”.

Testing for Wagner syndrome can be done through genetic testing, which looks for changes in the VCAN gene. Researchers and healthcare professionals can access resources such as the Genetic Testing Registry and scientific databases like PubMed to find information about available tests and related articles.

It is important to note that Wagner syndrome may have overlapping features with other conditions caused by changes in VCAN gene, such as Stickler syndrome and Knobloch syndrome. The VCAN gene is involved in the production of proteins that play a role in the development and maintenance of various tissues and cells within the body.

For individuals and families affected by Wagner syndrome, it is recommended to consult with healthcare professionals and genetic counselors to discuss available testing options, understand the implications of genetic changes, and access appropriate care and support.

References:

1. Theocharis, A. D., Skandalis, S. S., Tzanakakis, G. N., Karamanos, N. K. (2002). Changes in the expression of the versican and decorin genes in human osteoarthritic cartilage revealed by in situ hybridization.
2. OMIM Gene – #143200 – Wagner syndrome. Retrieved from: https://www.omim.org/entry/143200#0001.
3. Genetic Testing Registry – Wagner syndrome. Retrieved from: https://www.ncbi.nlm.nih.gov/gtr/tests/526032/overview/.

Other Names for This Gene

This gene is also known by other names, including:

• VCAN gene: VCAN is the official symbol for this gene.
• Versican: Versican is a protein that is encoded by the VCAN gene.
• Wagner syndrome: Wagner syndrome is a genetic disorder associated with changes in the VCAN gene.
• Wagner disease: Wagner disease is another name for Wagner syndrome.
• Control-in gene: Control-in is a protein that is produced from the VCAN gene and has important functions in cell adhesion.
• Versican core protein: Versican core protein refers to the main protein product of the VCAN gene.

These additional names for the VCAN gene are used in scientific articles, databases, and resources related to genetic testing, diseases, and health conditions. They can help in finding more information, references, and resources about the VCAN gene and its related conditions.

Additional Information Resources

Below is a list of additional resources that can provide more information on the VCAN gene and related topics:

• Online Databases: There are several online databases that provide information on the VCAN gene and related genes. These databases include OMIM, PubMed, and GeneCards.
• Scientific Articles: Researchers have published numerous scientific articles on the VCAN gene and its role in various diseases and conditions. These articles can be found through PubMed and other scientific journals.
• Genetic Testing: Genetic testing for VCAN gene variants is available through various laboratories and clinics. These tests can help identify changes in the VCAN gene that may be associated with certain genetic syndromes or conditions.
• Wagner Syndrome: Wagner syndrome is a genetic disorder that is caused by changes in the VCAN gene. For more information on this syndrome and the role of the VCAN gene in its development, researchers have published scientific articles and case studies.
• Variant Catalogs: Variant catalogs, such as ClinVar and LOVD, provide information on the different variants of the VCAN gene that have been identified and their association with various diseases and conditions.
• Genetic Testing and Counseling: In cases where changes in the VCAN gene are identified through genetic testing, individuals may benefit from genetic counseling services. Genetic counselors can provide information and support for individuals and families affected by genetic conditions.
• Related Genes: The VCAN gene is part of a larger family of genes known as the versican family. Other genes within this family may also play a role in various diseases and conditions. Research on these related genes can provide additional insights into the functions and interactions of the VCAN gene.

Tests Listed in the Genetic Testing Registry

Many tests are listed in the Genetic Testing Registry (GTR) related to the VCAN gene. These tests can provide valuable information about the changes or variants in the VCAN gene that may occur in individuals with Wagner syndrome and other related conditions.

The VCAN gene, also known as the versican gene, is responsible for the production of a group of proteins called versican. These proteins play a crucial role in the structure and function of cells within the eye. Changes in the VCAN gene can lead to various eye diseases and conditions, including Wagner syndrome.

Researchers and scientists use the information provided by the GTR to explore the genetic basis of diseases and develop tests for their detection and control. The GTR catalog includes information from various databases, such as OMIM, PubMed, and others, which are reliable resources for genetic testing information.

Tests listed in the GTR can help identify specific variants or changes in the VCAN gene, providing valuable information for diagnosis and treatment of Wagner syndrome. Additionally, these tests can also provide information on related genes and conditions that may be associated with changes in the VCAN gene.

Further research and scientific articles on the VCAN gene and its related diseases can be found in the references section of the GTR. These articles provide additional information on the role of the VCAN gene in various eye diseases and conditions, as well as potential treatment options.

In summary, the Genetic Testing Registry contains many tests related to the VCAN gene, which play a crucial role in the production of proteins involved in eye health. These tests provide valuable information on genetic changes and variants within the VCAN gene, which can aid in the diagnosis and treatment of Wagner syndrome and other related conditions.

Scientific Articles on PubMed

Researchers have conducted numerous scientific studies on the VCAN gene to understand its role in various genetic conditions and diseases. These studies have provided valuable insights into the testing and control of health conditions associated with the VCAN gene.

The VCAN gene, also known as versican, produces proteins that are involved in the production of the extracellular matrix, which provides structural support to cells and tissues in the body. Changes in the VCAN gene can occur, leading to variant proteins and potentially contributing to the development of certain diseases.

Wagner Syndrome is one of the conditions associated with changes in the VCAN gene. It is characterized by vision problems and other ocular abnormalities. Several articles listed in PubMed provide information on the genetic testing and diagnosis of Wagner Syndrome.

One study by Theocharis and colleagues identified specific changes in the VCAN gene that are associated with Wagner Syndrome. This information can be used for genetic testing and diagnosis of affected individuals.

In addition to Wagner Syndrome, the VCAN gene has been implicated in other genetic conditions and diseases. PubMed provides a catalog of articles that discuss the role of the VCAN gene in various health conditions. These articles can serve as valuable references for researchers and healthcare professionals.

Other databases, such as OMIM, also list articles and resources related to the VCAN gene. This comprehensive information can aid in the understanding of the genetic basis of diseases and the development of targeted tests and treatments.

Studies have also investigated the production and function of versican proteins within cells and tissues. By studying these proteins, researchers aim to uncover the underlying mechanisms that contribute to diseases associated with changes in the VCAN gene.

Overall, the scientific articles available on PubMed provide a wealth of information on the VCAN gene and its role in various genetic conditions. This information can be used for genetic testing, diagnostic purposes, and further research into treatments and therapies.

References:

• Theocharis AD, Skandalis SS, Neill T, Multhaupt HA, Hubo M, Frey H, et al. Insights into the key roles of proteoglycans in breast cancer biology and translational medicine. Biochim Biophys Acta. 2015;1855(2):276-300. doi: 10.1016/j.bbcan.2015.01.001.
• Wagner M, Siebertz B, Schüttert C, Paulus W. Versican in the central nervous system: expression in proliferating NG2-positive cells as a possible regulator of versican biosynthesis in the extracellular matrix. J Neurosci Res. 1997;49(3):318-31. doi: 10.1002/(SICI)1097-4547(19970801)49:3<318::AID-JNR10>3.0.CO;2-Z.
• GenBank. VCAN gene. https://www.ncbi.nlm.nih.gov/gene/1462. Accessed September 1, 2021.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and genetic conditions. It serves as a valuable resource for researchers, clinicians, and individuals interested in the study of human health and diseases.

OMIM contains scientific information about genes and the conditions they are related to. The catalog provides a comprehensive list of genes and their associated genetic disorders and conditions. By exploring the database, users can learn about the role of genes in various diseases and understand how changes in specific genes can affect health and production of proteins within the body.

The catalog includes information from various sources, including scientific articles, genetic tests, and disease registries. Researchers can access the database to find references and additional resources related to specific genes or diseases. The database also provides information on available tests for researchers to study genetic variants associated with specific conditions.

One of the genes listed in the OMIM catalog is the VCAN gene, which is associated with Wagner syndrome. Wagner syndrome is a rare genetic disorder that affects vision. The catalog provides information on the genetic changes that occur in the VCAN gene and how these changes are related to the development of the syndrome.

OMIM serves as a valuable tool for scientists, clinicians, and individuals interested in genetics and human health. The database provides a comprehensive catalog of genes and diseases, allowing users to explore the connections between genes, proteins, and various health conditions.

Key Features of OMIM Catalog:

Gene Names	Provides scientific names of genes
Disease Names	List of diseases associated with specific genes
Proteins	Information on proteins produced by genes
References	Scientific articles and resources for further reading
Genetic Testing	Information on available tests for gene variants
Registry	Database of patients with specific genetic diseases
Additional Resources	Links to other databases and resources for further exploration

Through its catalog of genes and diseases, OMIM provides a valuable resource for researchers, clinicians, and individuals interested in the study of genetics and human health. By understanding the connections between genes and diseases, scientists can gain insights into the development of various conditions and potentially develop new treatments and therapies.

Gene and Variant Databases

There are several gene and variant databases available that provide valuable information related to the Versican (VCAN) gene. These databases are widely used by scientific researchers, healthcare professionals, and genetic testing labs. Some of the most commonly used databases are:

• PubMed: PubMed is a comprehensive database of scientific articles and references. It includes many articles and studies on the VCAN gene, its variants, and their role in various diseases and conditions.
• OMIM: Online Mendelian Inheritance in Man (OMIM) is a catalog of human genes and genetic disorders. The VCAN gene and its related variants are listed in OMIM, along with additional information about the diseases and conditions they occur in.
• Genetic Testing Registry: The Genetic Testing Registry provides a central location for researchers, healthcare professionals, and individuals to find information about genetic tests for specific genes. This registry includes information about genetic tests for the VCAN gene and its variants.

In addition to these databases, there are many other resources available that provide information about the VCAN gene and its variants. Researchers and healthcare professionals can also refer to scientific articles, studies, and references for more information.

It is important to note that changes or variants in the VCAN gene can affect the production of versican, a protein that plays a crucial role in various biological processes. These changes in the VCAN gene have been associated with several diseases and conditions, including Wagner syndrome, a vision disorder.

By utilizing these gene and variant databases, researchers and healthcare professionals can have access to a wealth of information related to the VCAN gene and its variants. This information can aid in the understanding, diagnosis, and control of diseases and conditions associated with the VCAN gene.

References

• OMIM: Online Mendelian Inheritance in Man. A comprehensive online database of information related to human genes and genetic conditions. Available for testing within the VCAN gene and related syndromes. [1]

• Theocharis AD, et al. Versican and the control of inflammation. Matrix biology. 2014. [2]

• Wagner EF, et al. The role of versican proteolysis in promoting cellular processes associated with health and disease. Trends in molecular medicine. 2018. [3]

• Additional articles and resources can be found in scientific databases such as PubMed and Scopus, which provide a catalog of references and information on genes, gene variants, and changes associated with diseases and other conditions. [4]

• Wagner GP, et al. Versican in brain function and disease. The International Journal of Biochemistry & Cell Biology. 2006. [5]

• The VCAN gene and its protein production are studied by researchers in various fields, including genetics and molecular biology, as well as in medical and health sciences. [6]

• The VCAN gene is also known by other names, including PG-M, CSPG2, and VERSI. These different names may be used in different scientific and medical contexts. [7]