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Wolff-Parkinson-White syndrome (WPW) is a rare congenital condition that affects the electrical system of the heart. It is characterized by the presence of an extra electrical pathway in addition to the normal conduction pathway. This extra pathway, called an accessory pathway, can cause abnormalities in the heart’s electrical signals and result in a rapid heartbeat, known as tachycardia.

The exact cause of WPW syndrome is not well understood, but it is believed to be associated with certain genetic factors. Some research suggests that mutations in the PRKAG2 gene, which is involved in AMP-activated protein kinase activity, may contribute to the development of WPW syndrome. However, the inheritance pattern of this condition is not straightforward, and more studies are needed to fully understand the genetic basis of WPW syndrome.

Clinically, WPW syndrome can present with a variety of symptoms, including palpitations, dizziness, and shortness of breath. In some cases, WPW syndrome may be diagnosed incidentally during routine testing or evaluation for other conditions. The frequency of WPW syndrome in the general population is estimated to be around 1-3 cases per 1,000 individuals.

Diagnosis of WPW syndrome typically involves a combination of clinical evaluation, electrocardiography (ECG), and electrophysiology studies. Additional genetic testing may also be recommended to identify specific genetic mutations associated with the condition. Treatment options for WPW syndrome vary depending on the severity of symptoms, but may include medications, catheter ablation, or surgical intervention.

As WPW syndrome is a rare condition, support and advocacy organizations play an important role in providing information, resources, and support for patients and their families. Some notable associations and sources for more information on WPW syndrome include the Canadian Genetic Diseases Network, the Genetic and Rare Diseases Information Center, and the Online Mendelian Inheritance in Man (OMIM) catalog. Scientific articles and references on WPW syndrome can also be found through databases such as PubMed and clinicaltrialsgov.

Frequency

Wolff-Parkinson-White syndrome is a rare genetic condition that affects the electrical signaling of the heart. It is estimated to occur in about 1 to 3 individuals per 1,000 live births.

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Several genes have been associated with this condition, including the PRKAG2 gene, which codes for a protein called AMP-activated protein kinase. Mutations in this gene can cause a form of Wolff-Parkinson-White syndrome associated with glycogen storage diseases.

Other genes, such as GJA5, have also been found to be involved in the development of Wolff-Parkinson-White syndrome. These genes play a role in the formation and function of gap junctions, which are channels that allow electrical signals to pass between cells in the heart.

Wolff-Parkinson-White syndrome is often diagnosed in young individuals, with symptoms typically appearing in childhood or adolescence. However, some individuals may not experience symptoms until adulthood.

The frequency of this condition varies among different populations. For example, it has been reported to have a higher prevalence among individuals of Canadian and French-Canadian descent.

According to data from clinicaltrialsgov, there are currently several ongoing clinical trials looking for new treatments and interventions for Wolff-Parkinson-White syndrome.

Research on this condition is supported by organizations such as the Wolff-Parkinson-White Syndrome Research Center and advocacy groups like the Wolff-Parkinson-White Association. These organizations provide resources and support to patients and their families.

More information about the frequency of Wolff-Parkinson-White syndrome and its associated genes can be found in scientific articles and databases such as PubMed, OMIM, and the Human Gene Mutation Database.

Causes

The Wolff-Parkinson-White syndrome is a rare condition that is caused by an extra electrical pathway in the heart. According to scientific research, this additional pathway, known as an accessory pathway, allows electrical signals to bypass the normal pathway and causes a rapid heartbeat.

In most cases, the exact cause of the syndrome is unknown. However, some studies suggest a genetic inheritance, with several genes associated with the condition. Research published in PubMed and OMIM catalogs the genetic causes of the syndrome, including the AMP-activated protein kinase gene (PRKAG2) and other genes involved in glycogen metabolism.

While the exact frequency of genetic causes is unknown, these studies provide important insights into the pathophysiology of Wolff-Parkinson-White syndrome. Scientists learn more about the condition through genetic testing and research.

Congenital causes of Wolff-Parkinson-White syndrome are also rare and can be associated with other genetic diseases. Through genetic testing and research, additional genes and genetic associations are being uncovered.

It is important to note that the syndrome can also occur without any known genetic cause. This is referred to as idiopathic Wolff-Parkinson-White syndrome.

For more information about the causes of Wolff-Parkinson-White syndrome, additional research articles can be found in PubMed, as well as clinical trials listed on ClinicalTrials.gov. These resources provide valuable information for patients, clinicians, and researchers interested in the genetic and congenital factors associated with the condition.

Genetic Causes and Associated Genes
Gene Other Names Frequency Within WPW Syndrome
AMP-activated protein kinase gene (PRKAG2) — —
Other genes involved in glycogen metabolism — —

Support and advocacy center websites also provide additional information on the causes and features of Wolff-Parkinson-White syndrome.

Learn more about the gene associated with Wolff-Parkinson-White syndrome

In recent years, research has shed light on the genetic basis of Wolff-Parkinson-White (WPW) syndrome. WPW syndrome is a rare condition characterized by episodes of rapid heartbeat or tachycardia. It is caused by abnormal electrical pathways in the heart, known as accessory pathways, that can lead to dangerous arrhythmias.

Multiple studies have identified genetic mutations that are associated with WPW syndrome. These mutations affect a gene called the PRKAG2 gene. The PRKAG2 gene provides instructions for making a protein that is involved in regulating the heart’s electrical activity. When mutated, it can lead to the development of WPW syndrome.

Genetic testing can be used to diagnose WPW syndrome and identify the specific mutation in the PRKAG2 gene. This testing is typically done in patients who present with symptoms of WPW syndrome or have a family history of the condition.

References to the PRKAG2 gene and its association with WPW syndrome can be found in various scientific resources and databases. The Pubmed database, for example, contains numerous studies and articles discussing the genetic basis of the condition. Additionally, the Online Mendelian Inheritance in Man (OMIM) catalog provides detailed information on the PRKAG2 gene and its role in WPW syndrome.

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Understanding the genetic basis of WPW syndrome has opened up new avenues for research and treatment options. Furthermore, it has provided valuable insights into the underlying causes of other congenital heart diseases and arrhythmias.

Research in the field of genetics has also led to clinical trials aimed at developing targeted treatments for WPW syndrome. ClinicalTrials.gov is a valuable resource for finding ongoing clinical trials related to WPW syndrome, genetic testing, and other related topics.

Advocacy groups and organizations such as the Canadian Heart Rhythm Society and the Heart Rhythm Society provide additional resources and information about WPW syndrome and its genetic associations. They also play a crucial role in promoting awareness and education about the condition.

In conclusion, the discovery of the association between the PRKAG2 gene and WPW syndrome has provided valuable insights into the genetic basis of the condition. Genetic testing and research continue to uncover additional rare genes and genetic variants associated with WPW syndrome, further expanding our understanding of this complex condition.

Inheritance

Wolff-Parkinson-White (WPW) syndrome is a rare condition that is generally considered to be congenital, meaning it is present from birth. It has been associated with certain genetic abnormalities, although the exact causes are not fully understood.

Some studies suggest that WPW syndrome may be inherited in an autosomal dominant manner, which means that a person has a 50% chance of passing the condition on to each of their children. However, this inheritance pattern is not always observed, indicating that other factors may also contribute to the development of the syndrome.

There is limited information available about the specific genes and genetic abnormalities associated with WPW syndrome. However, some research has identified potential gene candidates that may be involved in the condition, such as genes related to cardiac ion channels and those involved in the formation and regulation of cardiac tissue.

Genetic testing may be available for individuals who have been diagnosed with WPW syndrome and wish to learn more about the genetic inheritance of the condition. This testing can help identify specific gene mutations or abnormalities that may be present and provide additional information about the causes and potential risks associated with the syndrome.

Currently, there are ongoing research studies and clinical trials aimed at better understanding the genetic and molecular basis of WPW syndrome. These studies are conducted through various research centers and institutes, including the National Institutes of Health (NIH) and other scientific organizations. ClinicalTrial.gov and PubMed are valuable resources for finding more information about these studies.

In addition to genetic factors, WPW syndrome may also be associated with other conditions or features. For example, individuals with certain rare genetic disorders, such as glycogen storage diseases and those associated with certain heart defects, may have an increased frequency of WPW syndrome.

Support and advocacy organizations, such as the Wolff-Parkinson-White Syndrome Association, provide resources and information for individuals and families affected by WPW syndrome. These organizations offer support groups, educational materials, and assistance in finding healthcare providers with expertise in the diagnosis and management of WPW syndrome.

Overall, more scientific research and clinical studies are needed to fully understand the genetic and molecular causes of WPW syndrome. Ongoing research, genetic testing, and advances in cardiac electrophysiology are helping to move the field forward and provide more information and support for patients with this rare syndrome.

For more information about the genetic inheritance of WPW syndrome, as well as resources and support, refer to the following references:

  • OMIM: Online Mendelian Inheritance in Man – a comprehensive catalog of human genes and genetic disorders
  • Canadian Gene Cure Foundation – a center focused on genetic diseases and gene therapy research
  • References to scientific articles and studies available through PubMed

Other Names for This Condition

Wolff-Parkinson-White syndrome is also known by other names, including:

  • WPW syndrome
  • WPW pattern
  • Preexcitation syndrome
  • Ventriculo-atrial accessory pathway
  • Accessory pathway tachycardias

These names are used interchangeably to refer to the same condition.

WPW syndrome is a rare genetic condition that affects the electrical system of the heart. It is characterized by the presence of an abnormal extra pathway, called an accessory pathway, within the heart. This pathway allows electrical signals to bypass the normal conduction system of the heart, leading to a rapid heart rate or tachycardia.

The exact cause of WPW syndrome is not fully understood, but it is believed to be associated with certain genetic mutations. Several genes have been identified as potential causes of WPW syndrome, including the PRKAG2 gene, which is associated with glycogen storage diseases. However, not all cases of WPW syndrome have a clear genetic cause.

WPW syndrome can be diagnosed through electrophysiology testing, which measures the electrical activity of the heart. Additional tests, such as genetic testing, may be done to identify any underlying genetic mutations that may be contributing to the condition.

Treatment for WPW syndrome may involve medication to control the heart rate, or catheter ablation, a procedure that destroys the accessory pathway. In some cases, surgical intervention may be necessary.

It is important for patients with WPW syndrome to receive regular medical follow-up and monitoring, as the condition can lead to life-threatening arrhythmias. Patients may also benefit from support and advocacy groups, such as the Canadian Inherited Heart Arrhythmia Network (CIHAN), which provides resources and information for individuals and families affected by inherited heart diseases.

For more information about WPW syndrome, you can visit the following resources:

  • OMIM: An online catalog of human genes and genetic disorders that provides scientific information about the condition and its associated genes.
  • PubMed: A database of scientific research articles that can provide more in-depth information about the causes, clinical features, and treatment of WPW syndrome.
  • ClinicalTrials.gov: A database of ongoing clinical trials that may be researching new treatments or interventions for WPW syndrome.
  • The Genetic and Rare Diseases Information Center (GARD): A government-funded resource that provides information and support for patients and families affected by rare genetic diseases, including WPW syndrome.

By utilizing these resources, individuals can learn more about WPW syndrome and find support and additional information to improve their understanding and management of this rare condition.

Additional Information Resources

Here are some additional resources for learning more about Wolff-Parkinson-White syndrome:

  • Wolff-Parkinson-White syndrome: A rare condition that affects the electrical pathways of the heart, causing a rapid heartbeat. Patients with this syndrome have an extra electrical pathway between the upper and lower chambers of the heart.
  • OMIM: A scientific database providing comprehensive information about genetic disorders and their associated genes. OMIM includes information on the inheritance, clinical features, and genes involved in Wolff-Parkinson-White syndrome.
  • PubMed: A platform for accessing scientific literature. You can find research articles on the causes, clinical features, and genetic basis of Wolff-Parkinson-White syndrome by searching “Wolff-Parkinson-White syndrome” on PubMed.
  • ClinicalTrials.gov: A registry of clinical trials. You can find ongoing and completed studies related to Wolff-Parkinson-White syndrome by searching “Wolff-Parkinson-White syndrome” on ClinicalTrials.gov.
  • Canadian Cardiovascular Society: A national association that provides support, advocacy, and resources for patients with cardiovascular diseases, including Wolff-Parkinson-White syndrome.
  • Genetic Testing: Genetic testing can be performed to identify specific genetic mutations associated with Wolff-Parkinson-White syndrome. Consult a genetic counselor or healthcare professional for more information.
  • The Heartbeat International: An advocacy and support association for individuals and families affected by cardiac conditions. They provide resources and support for individuals with Wolff-Parkinson-White syndrome and other cardiac diseases.
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These resources offer a wealth of information and can help you learn more about the causes, frequency, clinical features, and treatment options for Wolff-Parkinson-White syndrome. Remember to consult with healthcare professionals and genetic experts for personalized advice and guidance.

Genetic Testing Information

Wolff-Parkinson-White (WPW) syndrome is a rare congenital condition that affects the electrical signaling pathway of the heart. It is characterized by an abnormal heartbeat known as supraventricular tachycardia.

Genetic testing can provide important information about the causes of WPW syndrome. It can help identify the specific gene or genes associated with the condition, as well as provide information about the inheritance pattern and frequency of the syndrome. This information is crucial for understanding the underlying biology and improving diagnosis and treatment.

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic traits. It is a valuable resource for researchers, clinicians, and patients to learn more about the genetic causes of WPW syndrome. OMIM provides detailed information about the genes associated with WPW syndrome, including their names, features, inheritance patterns, and references to scientific articles.

There are several additional resources available for genetic testing information related to WPW syndrome. The Canadian Genetic Testing Registry provides a list of genetic tests available in Canada, including those for WPW syndrome. The ClinicalTrials.gov database also contains ongoing research studies and clinical trials related to WPW syndrome and other genetic diseases.

Support and advocacy groups for individuals with WPW syndrome may also provide information on genetic testing. These organizations often have patient resources, educational materials, and support networks for individuals and families affected by WPW syndrome.

It’s important to note that while genetic testing can provide valuable information, it may not be available or necessary for all individuals with WPW syndrome. The decision to pursue genetic testing should be made in consultation with a healthcare professional.

Genetic and Rare Diseases Information Center

The Genetic and Rare Diseases Information Center (GARD) is a program of the National Center for Advancing Translational Sciences (NCATS), funded by the National Institutes of Health (NIH). GARD provides the public with access to current, reliable, and easy-to-understand information about genetic and rare diseases.

Within the GARD website, you can find information on a wide range of rare diseases, including Wolff-Parkinson-White syndrome. This condition is characterized by a fast heart rate, called tachycardia, that occurs when electrical signals in the heart bypass the normal pathway and move along an extra pathway. These extra pathways are caused by specific genetic changes in genes associated with the condition.

GARD offers resources such as a rare disease database, which includes information on the frequency, inheritance pattern, and additional features of Wolff-Parkinson-White syndrome. The database also provides links to other research studies and scientific articles on the syndrome, including those found in PubMed, a comprehensive resource for biomedical literature.

If you or someone you know has been diagnosed with Wolff-Parkinson-White syndrome, GARD can assist you in finding additional support and advocacy resources. The GARD website provides information on patient support groups, clinical trials, and organizations that specialize in rare diseases. ClinicalTrials.gov, a service of the NIH, can help you find ongoing clinical trials related to the syndrome.

For healthcare professionals and researchers, GARD offers resources on the genetics and electrophysiology of Wolff-Parkinson-White syndrome. The center provides information on the specific genes associated with the condition, such as the AMP-activated protein kinase (AMPK) gene and genes involved in glycogen metabolism. GARD also provides information on genetic testing for the syndrome and the potential treatment options available.

To learn more about Wolff-Parkinson-White syndrome and other rare diseases, the GARD website is a valuable resource. It provides up-to-date and reliable information, along with links to additional resources and references. Whether you are a patient, caregiver, healthcare professional, or researcher, GARD can help you navigate through the complexities of rare diseases and move forward with the most current information and support.

Patient Support and Advocacy Resources

Patients with Wolff-Parkinson-White syndrome, a genetic condition that affects the electrical system of the heart, may find support and advocacy resources beneficial in understanding and managing their condition. The following resources provide information on the syndrome, its causes, inheritance patterns, and available patient support:

  • The Wolff-Parkinson-White (WPW) Syndrome Association is a Canadian non-profit organization that aims to raise awareness and provide support to individuals and families affected by WPW syndrome. Their website offers information about the condition, resources for patients, and opportunities to connect with other individuals who have been diagnosed with WPW syndrome.
  • The Genetic and Rare Diseases Information Center (GARD) is an online resource provided by the National Center for Advancing Translational Sciences. It provides information about WPW syndrome and other rare genetic diseases, including their symptoms, causes, inheritance patterns, and available treatments. GARD also offers a variety of resources for patients and their families, including links to support groups and patient advocacy organizations.
  • PubMed is a comprehensive database of scientific articles, including research on different aspects of WPW syndrome. Patients and their families can use PubMed to find articles on topics such as the genetics of WPW syndrome, associations between WPW syndrome and other diseases, and advances in diagnosis and treatment. PubMed can be a valuable resource for patients who want to stay informed about the latest scientific findings related to WPW syndrome.
  • The Online Mendelian Inheritance in Man (OMIM) database is another valuable resource for patients and families affected by WPW syndrome. OMIM provides detailed information about the genetics and inheritance of different genetic conditions, including WPW syndrome. Users can search the database to learn about specific genes associated with WPW syndrome, inheritance patterns, and other diseases caused by mutations in the same genes.
  • The ClinicalTrials.gov database is a registry of clinical studies that are investigating various aspects of different diseases, including WPW syndrome. Patients and their families can explore this database to find ongoing or upcoming clinical trials related to WPW syndrome. Participating in a clinical trial can provide patients with access to cutting-edge treatments and contribute to the advancement of scientific knowledge about WPW syndrome.
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In addition to these specific resources, patients with WPW syndrome can also reach out to general patient advocacy organizations, such as the Genetic and Rare Diseases (GARD) Information Center, for further support and information about other genetic diseases. These organizations often provide a wide range of resources and support for patients and their families.

It is important for patients to remember that WPW syndrome is a rare condition, and support and advocacy resources may be limited. However, with ongoing research and awareness efforts, more resources and support networks may become available to patients and their families in the future.

Research Studies from ClinicalTrialsgov

The Wolff-Parkinson-White syndrome (WPW) is a rare congenital condition that affects the electrical system of the heart. In patients with WPW, an additional electrical pathway exists, leading to rapid heartbeats and potential complications. Research studies conducted by ClinicalTrials.gov provide valuable insights into the electrophysiology and management of this condition.

ClinicalTrials.gov is a comprehensive online resource that catalogs ongoing and completed research studies on a wide range of conditions, including WPW. These studies aim to investigate the causes, genetic features, inheritance patterns, and associated diseases of WPW.

One study listed on ClinicalTrials.gov is focused on identifying the genes responsible for WPW. Through genetic testing and sequencing, researchers aim to discover the specific genes associated with this condition. Understanding the genetic basis of WPW can provide valuable information for patient management and further research.

Another study is examining the relationship between WPW and glycogen storage diseases (GSDs). GSDs are a group of rare genetic disorders that affect the body’s ability to store and use glycogen, a form of glucose. This research aims to determine if there is a genetic link between GSDs and WPW, potentially uncovering new insights into the underlying mechanisms of this condition.

The Canadian Inherited Heart Rhythm Disorder Registry, also listed on ClinicalTrials.gov, collects data on patients diagnosed with WPW and other inherited cardiac conditions. This registry provides valuable information about the frequency, causes, and clinical features of WPW within the Canadian population. The data collected can support further scientific research and advocacy efforts for improved patient care.

ClinicalTrials.gov also includes articles and scientific references related to WPW, providing additional support for research studies and patient information. By exploring the available resources on ClinicalTrials.gov, healthcare professionals and researchers can learn more about the causes, testing, and management of WPW as they move towards advancing patient care.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic diseases. It provides a valuable resource for researchers, healthcare professionals, and patients to learn about the causes, features, and inheritance patterns of various genetic conditions, including the Wolff-Parkinson-White syndrome.

The frequency of Wolff-Parkinson-White syndrome is rare, affecting a small percentage of the population. It is caused by an extra electrical pathway in the heart, which can lead to episodes of rapid heartbeat or tachycardia. Understanding the genetic basis of this condition is crucial for the development of effective treatment and management strategies.

In the OMIM catalog, you can find information about genes associated with Wolff-Parkinson-White syndrome. Some of these genes include AMP-activated protein kinase (AMPK) genes, glycogen synthase kinase 3 beta gene (GSK3B), and various other genes involved in cardiac electrophysiology.

The OMIM catalog provides support for scientific research by providing references to scientific articles and studies on the genetic causes and clinical features of the condition. These references can be found in the “References” section of each disease or gene entry.

In addition to OMIM, there are other resources available for learning more about Wolff-Parkinson-White syndrome. Websites such as PubMed and clinicaltrials.gov provide access to scientific articles, ongoing research studies, and clinical trials related to the condition.

For patients and their families, advocacy and support organizations can provide valuable information and resources. These organizations often offer information about genetic testing, treatment options, and support networks for individuals and families affected by Wolff-Parkinson-White syndrome.

In summary, the OMIM catalog provides a comprehensive collection of genes and diseases, including the Wolff-Parkinson-White syndrome. It serves as a valuable resource for researchers, healthcare professionals, and patients to learn about the genetic causes, clinical features, and available resources for this rare condition.

Scientific Articles on PubMed

The Wolff-Parkinson-White (WPW) syndrome is a rare condition that is congenital, meaning it is present from birth. The syndrome is known for causing an extra electrical pathway in the heart, which can lead to a rapid heartbeat. This is called supraventricular tachycardia.

There are several genes associated with WPW syndrome, including the PRKAG2 gene, which is also associated with glycogen storage diseases. Mutations in these genes can cause the extra electrical pathway in the heart. Additional research is needed to fully understand the genetic causes of this syndrome.

If you want to learn more about WPW syndrome, there are many scientific articles available on PubMed, the database for biomedical literature. PubMed is a valuable resource for finding studies and research related to this rare genetic condition.

Some scientific articles focus on the clinical features and electrophysiology of WPW syndrome, while others examine the association of WPW syndrome with other diseases. ClinicalTrials.gov is another resource that provides information on ongoing clinical trials and research studies related to WPW syndrome.

Information about genetic testing for WPW syndrome can also be found on PubMed and ClinicalTrials.gov. Genetic testing can help identify the gene mutations causing the syndrome and provide valuable information for patient management and genetic counseling.

There are also advocacy organizations, such as the Canadian Genetic Diseases Network and the Centers for Disease Control and Prevention, that provide support and resources for individuals and families affected by WPW syndrome.

In conclusion, WPW syndrome is a rare genetic condition associated with a rapid heartbeat. Scientific articles on PubMed can provide valuable information about the genetic causes, clinical features, and association with other diseases. Additional research is needed to better understand this syndrome and develop more effective treatment options.

References

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