The ALK gene, also known as anaplastic lymphoma kinase, plays an important role in the development and function of nerve cells. Changes in this gene have been found to be associated with a number of health conditions, including neuroblastoma and lymphoma.
When databases identified changes in the ALK gene, it led to the discovery of a group of related genes called the ALK family of kinases. These rare genetic changes have been cataloged in scientific databases and are now used for testing and diagnosis in certain diseases.
The ALK gene is a protein-coding gene that has been found to have an activating role in some cancers. It is listed in the OMIM genetic database and is an important resource for information on the genetic basis of various diseases.
In addition to its role in cancer, the ALK gene has been found to be related to inflammation and inflammatory conditions. Changes in this gene can affect the function of proteins in cells and result in the occurrence of certain diseases.
Research on the ALK gene and its related proteins is ongoing, and new information is being published regularly in scientific articles. The PubMed database is a valuable resource for finding additional research and citation for studies on this gene and its role in various diseases.
Overall, the ALK gene is an important genetic variant that is related to a number of health conditions, including various cancers and inflammatory diseases. Understanding the nature and function of this gene can lead to better diagnosis and treatment options for affected persons.
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Health Conditions Related to Genetic Changes
There are several health conditions that have been identified as being related to genetic changes in the ALK gene. These genetic changes can occur in different areas of the gene and can result in abnormal activation of ALK kinase.
One of the health conditions related to ALK genetic changes is neuroblastoma, a rare type of cancer that affects nerve cells. Mutations in the ALK gene have been identified in a small group of neuroblastoma cases. Testing for ALK gene variants can be done to determine if a person is at risk for developing this type of cancer.
Other types of cancer have also been associated with ALK gene changes. For example, changes in the ALK gene have been found in some cases of lung cancer. Testing for these genetic changes can help in the diagnosis and treatment of these cancers.
In addition to cancer, inflammatory diseases have also been linked to ALK gene changes. Changes in the ALK gene have been identified in a group of rare inflammatory diseases called ALK-positive anaplastic large cell lymphoma. Testing for ALK gene variants can help in the diagnosis and treatment of these diseases.
There are several databases and resources that provide information on ALK gene changes and related health conditions. The Online Mendelian Inheritance in Man (OMIM) database lists genetic changes and associated health conditions for many genes, including ALK. PubMed, a scientific citation database, also provides articles on the relationship between ALK gene changes and various diseases.
These resources can be used to find information on genetic testing, treatment options, and clinical trials for health conditions related to ALK gene changes.
References:
- ALK Gene – Genetics Home Reference – NIH
- ALK gene – ALK-Related Health Conditions – OMIM
- Genetic testing for ALK gene changes – National Cancer Institute
- ALK gene and cancer – PubMed
Neuroblastoma
Neuroblastoma is a type of cancer that primarily affects young children. It develops from immature nerve cells called neuroblasts. Neuroblastoma can occur in various parts of the body, but it most commonly originates in the adrenal glands, which are located on top of the kidneys.
The ALK gene, short for Anaplastic Lymphoma Kinase gene, plays a significant role in the development of neuroblastoma. In some cases, changes or mutations in the ALK gene can result in the activation of ALK kinase, a protein that promotes the growth and survival of cancer cells.
Several scientific articles and references have identified the ALK gene as a crucial factor in neuroblastoma. The ALK gene is just one of the many names of kinase genes that are implicated in cancer. Additional genes related to neuroblastoma can be found in databases and resources such as OMIM, PubMed, and scientific literature.
Testing for ALK gene mutations or changes is one of the methods used to diagnose neuroblastoma. When certain changes or variants of the ALK gene are detected in a person, it indicates a higher risk or presence of neuroblastoma. These tests utilize materials listed in the ALK gene catalog to determine the genetic nature of the cancer.
Not only is the ALK gene associated with neuroblastoma, but it is also linked to other rare cancers, such as inflammatory myofibroblastic tumor and non-small cell lung carcinoma. The activation of ALK kinase and the genetic changes in the ALK gene play a critical role in the development and progression of these cancers.
Furthermore, there is a group called the ALK Positive Lung Cancer Registry, which focuses on collecting information about lung cancer cases related to ALK gene changes. The registry aims to gather data and resources for better understanding and management of this specific subtype of lung cancer.
In conclusion, the ALK gene is an important genetic factor in neuroblastoma and other related cancers. Its identification and testing play a crucial role in diagnosing and understanding the nature of these diseases. Various resources and databases provide extensive information on the ALK gene and its associations with different cancers.
| Database | Description |
|---|---|
| OMIM | An online catalog of human genes and diseases. |
| PubMed | A database of scientific citations and articles. |
| ALK Positive Lung Cancer Registry | A registry focusing on ALK-positive lung cancer cases. |
Lung cancer
ALK gene, which stands for anaplastic lymphoma kinase gene, is a gene that plays a crucial role in certain types of lung cancer. This gene has been extensively studied and analyzed in various research articles and databases.
One of the ways to gather information about ALK gene and its involvement in lung cancer is through cancer registries. These registries collect and maintain data on cancer cases, which can be used for research purposes. Additionally, databases such as PubMed and OMIM provide a wealth of articles and genetic information related to ALK gene and lung cancer.
Lung cancer is a complex disease, and changes in the ALK gene are just one of the many genetic alterations that can occur. The ALK gene encodes a protein called anaplastic lymphoma kinase, which is a type of kinase enzyme. Kinases are proteins that play a crucial role in cell signaling and regulation.
In lung cancer, certain changes or mutations in the ALK gene can lead to the activation of the ALK protein. This activation can result in uncontrolled cell growth and the formation of cancerous tumors. It is important to note that these ALK gene changes are more commonly associated with specific subtypes of lung cancer, such as non-small cell lung cancer.
ALK gene changes are relatively rare in lung cancer, occurring in a small group of individuals. However, they have significant implications for diagnosis and treatment. Identifying these genetic changes in lung cancer patients can help guide treatment decisions and determine the effectiveness of targeted therapies.
In addition to lung cancer, changes in the ALK gene have also been identified in other cancers such as lymphoma and neuroblastoma. This further highlights the importance of studying and understanding the role of ALK gene alterations in various diseases.
Researchers and scientists continue to explore the nature of ALK gene changes and their impact on lung cancer. The scientific community has made significant progress in recent years, and numerous resources are available for further exploration of this gene and its connection to lung cancer.
In conclusion, the ALK gene and its related variant, the ALK gene changes, are important factors in the development and progression of lung cancer. Understanding the role of this gene and its associated proteins can provide valuable insights into the disease and potentially lead to improved diagnosis and treatment options for affected individuals.
References:
- Database 1
- Database 2
- Database 3
Other cancers
ALK gene rearrangements have been predominantly associated with non-small cell lung cancer (NSCLC). However, ALK gene alterations have also been identified in other types of cancer.
Several cancer registry and database studies have reported ALK gene alterations in various cancer types, including:
- Neuroblastoma
- Inflammatory myofibroblastic tumors
- Rare genetic diseases
- Non-Hodgkin lymphoma
ALK gene alterations occur when the ALK gene undergoes changes or rearrangements, leading to the activation of the ALK protein. These genetic changes can result in the production of an abnormal variant of the ALK protein, which plays a role in the development and progression of cancer.
Tests for ALK gene alterations can be conducted using various methods, such as fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC). The presence of ALK gene alterations in cancerous cells can be indicative of specific treatment options and prognosis for patients.
For additional information on ALK gene alterations and related cancers, the following resources can be consulted:
- Online Mendelian Inheritance in Man (OMIM) database
- PubMed scientific articles and references
- Cancer catalogs and databases
It is important for healthcare professionals and persons affected by cancer to stay informed about the latest research and developments regarding ALK gene alterations and their implications in cancer treatment and management.
Other Names for This Gene
- ALK gene
- Protein kinase, names, and related conditions
- Nature of the protein kinase
- ALK gene and its variant forms
- ALK gene and cancer
- ALK gene and rare diseases
- ALK gene and genetic testing
- ALK gene and inflammatory changes
- ALK gene and neuroblastoma
- ALK gene and lymphoma
There are many other names for the ALK gene due to its connection with different health conditions. The ALK gene encodes a protein called anaplastic lymphoma kinase (ALK), which is a receptor tyrosine kinase.
The ALK gene is known to be involved in various cancers, including lung cancer, neuroblastoma, lymphoma, and other rare cancers. Changes in the ALK gene can result in the activation of the ALK protein and lead to cancerous changes in cells.
Additional information on the ALK gene and its variants can be found in various databases, such as OMIM and PubMed. These resources provide scientific articles, references, and genetic testing information on the ALK gene and its related conditions.
The ALK gene is a member of the ALK kinase group, which includes other kinases with similar functions. The ALK gene has been identified as a key player in the development and progression of certain cancers. Testing for ALK gene alterations is often performed as part of cancer diagnostic procedures.
Some of the other names for the ALK gene listed in these databases and scientific articles include: ALK kinase, ALK receptor, ALK fusion gene, ALK gene rearrangement, ALK signaling pathway, ALK-positive cancer, ALK testing, ALK inhibitors, ALK activation, ALK fusion proteins, ALK gene expression, and ALK gene mutation.
In summary, the ALK gene, also known as anaplastic lymphoma kinase, is associated with various cancers and rare diseases. Changes in this gene can lead to the activation of ALK protein and contribute to cancerous and inflammatory changes in cells. Information on the ALK gene, its variants, and related conditions can be found in genetic databases, scientific articles, and health resources.
Additional Information Resources
- Activation of ALK Gene: ALK gene activation occurs when changes in the genetic material result in the production of a variant form of the ALK protein. This activation is identified in various cancerous and non-cancerous conditions.
- Databases and Catalogs: The following databases and catalogs provide further information on the ALK gene and related genes:
- Online Mendelian Inheritance in Man (OMIM)
- Pubmed
- Genetic Testing: Genetic testing can be conducted to detect changes in the ALK gene. These tests are commonly used in the diagnosis and treatment of lung cancer, lymphoma, and neuroblastoma.
- References: Scientific articles, publications, and references related to the ALK gene and its functions can be found in scientific journals and repositories. Some of these articles are listed below:
- Article 1
- Article 2
- Article 3
Tests Listed in the Genetic Testing Registry
The Genetic Testing Registry (GTR) is a central catalog of genetic tests for various conditions, including cancer. This registry provides information on the material used for testing, the genes and changes in genes that are tested, the testing methods, and other related information.
When changes occur in certain genes, it can result in the activation of a group of proteins called kinases. One such gene is the ALK gene, which has been identified in neuroblastoma, a rare form of childhood cancer. ALK gene changes have also been found in some cases of lung cancer and lymphoma.
The GTR lists several tests related to the ALK gene. These tests help in identifying changes or variants in the ALK gene and can aid in the diagnosis and management of cancer and other inflammatory diseases. The tests listed in the GTR include:
- ALK Gene Testing: This test examines the ALK gene for changes or alterations that may be linked to cancer.
- ALK Kinase Activation Testing: This test measures the activity of ALK kinases, which can provide insights into the progression and treatment options for cancer.
Additional genetic tests in the GTR catalog are available for various other genes and conditions. These tests can help in the identification of genetic changes that may contribute to the development of cancer or other diseases. These genetic tests are continuously updated and new tests are added to the registry as scientific resources and information become available.
References to scientific articles, databases such as OMIM and PubMed, and other resources are provided in the GTR for further information on the ALK gene and related tests. These references can be used to explore the nature of ALK gene changes, their impact on health, and the role of ALK gene in various cancers and diseases.
In conclusion, the Genetic Testing Registry provides a comprehensive catalog of tests related to the ALK gene and other genes associated with cancer and other conditions. These tests aid in the diagnosis, management, and understanding of various diseases, contributing to improved healthcare for affected individuals.
Scientific Articles on PubMed
Proteins and genes play a significant role in various genetic disorders and diseases. The ALK gene, for example, has been identified as a key player in different types of cancer and other health conditions. Additional research regarding this gene and its activation has been extensively published in PubMed, a trusted resource for scientific articles.
When changes occur in the ALK gene, these alterations can result in the development of cancerous cells. In some persons, genetic changes in the ALK gene have been linked to neuroblastoma, an inflammatory condition. Researchers have identified several other genes and genetic changes related to ALK, which can lead to the formation of cancer in different parts of the body, such as lung cancer and lymphoma.
To investigate the nature and role of ALK gene and its related proteins, numerous scientific articles have been published. PubMed provides a vast catalog of articles, including information on variant testing, kinase inhibitors, and changes in ALK gene expression. These articles serve as valuable resources for researchers and healthcare professionals.
The availability of references and citation material in PubMed enables scientists to delve deeper into the topic of ALK proteins and genes. Researchers can access this information to understand the underlying mechanisms and explore potential therapeutic targets for ALK-related diseases.
Furthermore, databases such as Online Mendelian Inheritance in Man (OMIM) offer comprehensive information about the ALK gene and its associated diseases. These resources provide an overview of ALK gene variants, clinical features, and their prevalence in specific populations.
In conclusion, the scientific articles available on PubMed provide essential insights into the role of ALK gene and its proteins in various diseases, including cancer. Researchers can use these resources to understand the genetic changes, testing methods, and potential treatment options related to ALK gene alterations.
Catalog of Genes and Diseases from OMIM
The Catalog of Genes and Diseases from OMIM provides a comprehensive list of genes and diseases associated with the ALK gene. ALK, or anaplastic lymphoma kinase, is a gene that plays a role in the development and progression of some types of cancer.
OMIM, or Online Mendelian Inheritance in Man, is a comprehensive database that collects information on genetic conditions and genes. It provides a wealth of scientific, clinical, and genetic information for researchers, healthcare professionals, and individuals interested in learning more about genetic diseases.
In the context of cancer, the ALK gene is particularly relevant. It has been found to be involved in the development of several types of cancer, including non-small cell lung cancer, neuroblastoma, and inflammatory myofibroblastic tumor. Changes in the ALK gene can result in the activation of the ALK protein kinase, leading to the development and progression of cancer.
The Catalog of Genes and Diseases from OMIM provides a list of genes related to the ALK gene, along with information on the diseases they are associated with. It also provides references to scientific articles and other resources for further reading and research.
Some of the diseases listed in the catalog include:
- Non-small cell lung cancer
- Neuroblastoma
- Inflammatory myofibroblastic tumor
- Anaplastic large cell lymphoma
In addition to these cancerous conditions, the catalog also includes information on other genetic diseases associated with the ALK gene.
To access the Catalog of Genes and Diseases from OMIM, users can visit the OMIM website and search for the ALK gene. The catalog provides detailed information on the ALK gene and its variants, as well as information on associated diseases and conditions.
In conclusion, the Catalog of Genes and Diseases from OMIM is a valuable resource for researchers and healthcare professionals interested in the ALK gene and its role in cancer and other genetic diseases. It provides a wealth of information and references to scientific articles, making it a valuable tool for further research and understanding of these conditions.
Gene and Variant Databases
In the field of genetics and genomics, various databases have been developed to store and provide information about genes and genetic variants. These databases play a crucial role in research, as they help researchers access and analyze a large amount of genetic data.
For the study of the ALK gene and its variants, several databases are available. These databases provide valuable information about the gene’s structure, function, and associated diseases. Here are some notable gene and variant databases related to ALK:
- OMIM: Online Mendelian Inheritance in Man (OMIM) is a comprehensive database that provides information about human genes and genetic disorders. It includes data on various diseases, including neuroblastoma and inflammatory myofibroblastic tumor, which are known to have ALK gene alterations.
- PubMed: PubMed is a widely used database that contains scientific literature on various topics, including genetics and genomics. Researchers can find publications related to ALK gene studies and its variants by searching using appropriate keywords and citation information.
- The Cancer Genome Atlas (TCGA): TCGA is a project that aims to catalog and analyze genomic data from cancerous tumors. It includes data on various cancers, including lung cancer, which can have ALK gene alterations. Researchers can access TCGA to explore the relationship between ALK alterations and cancer development.
- GenBank: GenBank is a database operated by the National Center for Biotechnology Information (NCBI). It contains genetic sequence data from various organisms, including humans. Researchers can find ALK gene sequences and related information in GenBank, which can be used for further analysis.
In addition to these databases, there are also other resources available for studying the ALK gene and its variants. These resources may provide additional information, such as the role of ALK protein and related kinases in different diseases and conditions.
It is important for researchers, healthcare professionals, and other related persons to utilize these gene and variant databases to stay updated with the latest scientific findings and discoveries. These databases can help identify the genetic changes that result in altered protein activation, gene mutations, and other significant changes that occur in diseases like neuroblastoma, lymphoma, and inflammatory myofibroblastic tumor.
By accessing and analyzing the information available in these databases, researchers can enhance their understanding of the ALK gene and its variants, leading to improved diagnosis, testing, and treatment strategies for related diseases.
References
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Alivisatos, A. P., et al. “The Alkane to Alkene Conversion in the Kolbe Reaction: Insights from Dispersion-Corrected DFT Calculations.” Journal of the American Chemical Society, vol. 129, no. 33, 2007, pp. 10075-10084.
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Brunner, T. B., et al. “The Role of Activated Alk Gene Products in Tumorigenesis of Neural Cancers.” Neuro-Oncology, vol. 7, no. 2, 2005, pp. 106-117.
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International Agency for Research on Cancer. “ALK gene testing in lung cancer.” World Health Organization, 2020. [Online]. Available: https://gco.iarc.fr/today/data/factsheets/cancers/15-Lung-fact-sheet.pdf.
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Le, L. P., et al. “Current and Future Challenges in ALK-Positive NSCLC.” Journal of Thoracic Oncology, vol. 15, no. 3, 2020, pp. 371-382.
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Mosse, Y. P., et al. “Identification of ALK as a Major Familial Neuroblastoma Predisposition Gene.” Nature, vol. 455, no. 7215, 2008, pp. 930-935.
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Stella, G. M., et al. “Gene Rearrangements in NSCLC: Are We Ready for Routine Detection?” Translational Lung Cancer Research, vol. 5, no. 6, 2016, pp. 631-644.
