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The CDT1 gene, also known as CDT1 origin recognition complex subunit 1, plays a crucial role in cell replication and DNA copying. This gene is responsible for encoding a protein that is involved in the initiation of DNA replication during the cell cycle. Any changes or variants in this gene can lead to a shortening or reduction in the replication capacity of cells, causing various genetic conditions and diseases.

Testing for genetic variants of the CDT1 gene can be conducted to determine if an individual carries any changes or mutations that may impact their health. The results of these tests can provide valuable information for the diagnosis and management of related genetic conditions and diseases.

Scientific databases such as PubMed, OMIM, and the Genetic Testing Registry provide additional resources and references for further study and testing on the CDT1 gene. These databases list articles, studies, and other related information that can contribute to a better understanding of the role of this gene in human health and diseases.

One example of a genetic condition associated with the CDT1 gene is Meier-Gorlin syndrome. This syndrome is characterized by abnormal growth and development, and individuals with this condition may have variations or mutations in the CDT1 gene. Research and testing on this specific gene variant can help identify potential therapeutic targets and interventions for individuals affected by this syndrome.

Genetic changes in the CDT1 gene can lead to various health conditions. CDT1 is a protein-coding gene involved in the regulation of DNA replication in cell division. Changes in this gene can result in a reduction or loss of function of the CDT1 protein, which can have significant effects on the cell cycle.

The Meier-Gorlin syndrome (MGS) is one of the health conditions related to genetic changes in the CDT1 gene. This syndrome is characterized by a small stature, small ears, and small or absent kneecaps. It is caused by mutations in several genes, including CDT1.

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Other genetic changes in the CDT1 gene have been identified in scientific studies and are listed in various databases and resources. These changes include different types of genetic variants, such as missense, frameshift, and nonsense mutations.

Testing for genetic changes in the CDT1 gene can be done through different genetic testing methods. These tests can help identify specific changes in the gene and provide information on the associated health conditions. Proper genetic counseling is advised before and after testing.

References to scientific articles and additional resources on health conditions related to genetic changes in the CDT1 gene can be found in databases such as PubMed and OMIM. These resources contain valuable information on the genes, diseases, and protein changes associated with the CDT1 gene.

References:
Resource Information
PubMed A database of scientific articles
OMIM Online Mendelian Inheritance in Man

These resources provide access to a wealth of information for researchers, healthcare professionals, and individuals interested in understanding the genetic changes and associated health conditions related to the CDT1 gene.

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Meier-Gorlin syndrome

Meier-Gorlin syndrome is a genetic condition that affects the development and growth of many parts of the body. It is characterized by short stature, small ears, and absent or underdeveloped kneecaps. The syndrome is caused by changes in the CDT1 gene, which plays a role in DNA replication and cell division.

Genetic testing is available for Meier-Gorlin syndrome. This test can identify changes in the CDT1 gene and help confirm a diagnosis. It can also help determine the specific variant of the gene that is responsible for the syndrome. The test is typically performed using a blood sample.

For additional information on Meier-Gorlin syndrome, related genes, and genetic testing, several resources are available. The Online Mendelian Inheritance in Man (OMIM) database provides a comprehensive catalog of information on genetic conditions, including Meier-Gorlin syndrome. It includes names, references, and scientific articles related to the syndrome.

Other databases, such as PubMed, also contain information on Meier-Gorlin syndrome. PubMed is a database of scientific articles and references, many of which are related to genetic conditions and diseases. It can be a valuable resource for finding up-to-date research on Meier-Gorlin syndrome and the associated genetic changes.

Genetic counseling is often recommended for individuals with Meier-Gorlin syndrome. This can provide valuable information about the condition, genetic testing options, and any potential risks or concerns. A genetic counselor can help individuals and families understand the implications of genetic changes and their impact on health.

In summary, Meier-Gorlin syndrome is a genetic condition caused by changes in the CDT1 gene. Genetic testing can help confirm a diagnosis and identify the specific variant of the gene that is responsible. Resources such as OMIM and PubMed provide additional information on the syndrome and related genetic changes. Genetic counseling is recommended for individuals with Meier-Gorlin syndrome to better understand the condition and its implications.

Other Names for This Gene

  • CDT1 gene
  • Cdc10-dependent transcript 1
  • Origin recognition complex subunit 1
  • ORC1
  • Cell division cycle 10-related protein
  • HsORC1
  • Human orc1 homolog
  • CHAF1A-associated factor 1A
  • KIAA0161
  • Meier-Gorlin syndrome, autosomal recessive 1
  • MGORS1 gene

Additional Information Resources

In addition to the CDT1 gene, there are other genes that are associated with Meier-Gorlin syndrome. These genes can be found in scientific databases and registries dedicated to genetic information. Some of the resources for finding more information on genes related to Meier-Gorlin syndrome include:

  • OMIM – Online Mendelian Inheritance in Man (OMIM) is a comprehensive catalog of human genes and genetic diseases. It provides information on the genetic basis of diseases, including Meier-Gorlin syndrome.
  • Genetic Testing Registry – The Genetic Testing Registry (GTR) is a database of genetic tests for various diseases and conditions. It lists the tests available for Meier-Gorlin syndrome and provides information on the laboratories that offer these tests.
  • PubMed – PubMed is a database of scientific articles in the field of biomedicine. It contains a vast amount of information on genetic research, including studies on Meier-Gorlin syndrome and related genetic changes.

In addition to these resources, there are other databases and registries that may contain relevant information on Meier-Gorlin syndrome, genetic changes, and related diseases. It is recommended to consult these resources for further details and references.

Tests Listed in the Genetic Testing Registry

This section provides information on the tests listed in the Genetic Testing Registry related to the CDT1 gene. The genetic testing registry is a catalog of genetic tests and their associated information, including the names of the tests, the genes involved, and the conditions or syndromes for which the tests are intended.

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The Genetic Testing Registry (GTR) is a resource provided by the National Institutes of Health (NIH) and is freely available to the scientific and medical community. It includes information on genetic tests offered by various laboratories and clinics, as well as information on the genes and conditions related to these tests.

Tests listed in the GTR for the CDT1 gene include:

  • Meier-Gorlin syndrome testing: This test is designed to detect changes or variants in the CDT1 gene that are associated with Meier-Gorlin syndrome, a genetic condition characterized by short stature and reduction in cell growth.

For additional information on genetic testing for the CDT1 gene and related conditions, the GTR provides references to scientific articles, medical databases, and resources such as PubMed and OMIM. These resources can provide more detailed information on the specific tests available, the genes involved, and the associated diseases or syndromes.

It is important to note that the information provided in the GTR is constantly evolving, as new tests, genes, and conditions are discovered. Therefore, it is recommended to regularly consult the GTR for the most up-to-date information on genetic testing for the CDT1 gene and related conditions.

Scientific Articles on PubMed

PubMed is a valuable resource for finding scientific articles related to the CDT1 gene and its variants. By searching for “CDT1 gene” in PubMed, researchers and healthcare professionals can access a wealth of information on this gene and its role in various genetic conditions.

There are several key articles listed on PubMed that provide important insights into CDT1 gene variants and their impact on human health. These articles highlight the importance of genetic testing and the identification of specific changes in the CDT1 gene that are associated with Meier-Gorlin syndrome, a condition characterized by abnormally short stature and other developmental abnormalities.

In addition to the scientific articles themselves, PubMed also provides additional resources for researchers and healthcare professionals. The Online Mendelian Inheritance in Man (OMIM) database, for example, is a valuable tool for accessing detailed information on genetic conditions and the genes associated with them. Researchers can also find references to other related articles in PubMed, allowing them to explore a broader range of information on the CDT1 gene and its role in human health.

By consulting PubMed and related databases, scientists and clinicians can gather important information on the CDT1 gene and its implications for various genetic diseases. This information can inform genetic testing strategies, guide treatment decisions, and ultimately improve the health outcomes of individuals affected by conditions related to the CDT1 gene.

Overall, PubMed is a comprehensive and reliable resource for accessing scientific articles, genetic information, and references related to the CDT1 gene and its role in human health.

Catalog of Genes and Diseases from OMIM

OMIM, which stands for Online Mendelian Inheritance in Man, is a comprehensive database that provides information on genes and diseases. It serves as a valuable resource for researchers, clinicians, and individuals interested in understanding the genetic basis of various disorders.

The catalog contains a vast collection of scientific articles and references from PubMed, a widely used database of scientific publications. It also includes genetic information from the OMIM registry, which stores data on genetic variants and their associated diseases.

In addition, the catalog provides a list of related genes and their corresponding diseases. This information can be particularly useful for researchers studying diseases at the cellular level. It enables them to identify genes that may be responsible for certain conditions and conduct further testing.

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The catalog covers a wide range of conditions, both common and rare. It includes syndromes, genetic disorders, and other health conditions. The short names of diseases listed in the catalog are accompanied by their corresponding OMIM numbers, which serve as unique identifiers for each condition.

Moreover, the catalog highlights notable genetic changes and variants associated with specific diseases. This information is crucial for understanding the molecular basis of diseases and developing targeted treatments.

To facilitate easy access and retrieval of information, the catalog is organized into categories. The information is presented in a tabular format, with columns for gene names, disease names, OMIM numbers, and protein changes.

In summary, the catalog of genes and diseases from OMIM is a valuable resource for researchers and clinicians in the field of genetics. It provides a comprehensive collection of scientific articles, references, and genetic information, aiding in the understanding and diagnosis of various diseases.

Gene and Variant Databases

In order to understand the conditions and diseases related to the CDT1 gene, it is important to access gene and variant databases. These databases provide essential information about genetic changes and their associated health impacts. Below are some of the commonly used gene and variant databases:

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive catalog of genes and genetic conditions. It provides detailed information on the genes, diseases, and related articles from scientific literature. This database is a valuable resource for researchers and healthcare professionals.

  • GeneTests: GeneTests is a registry of genes and genetic tests for various conditions. It includes information on genes, genetic conditions, laboratories offering genetic testing, and additional resources for patients and healthcare providers.

  • PubMed: PubMed is a database of scientific articles and journals. It can be used to search for research papers related to the CDT1 gene and its associated diseases. PubMed provides a wealth of information for scientific and medical professionals.

Furthermore, genetic databases such as OMIM and GeneTests list the names of genes, associated diseases, and variant changes. These databases are essential tools for understanding the genetic basis of diseases and identifying potential genetic variants associated with conditions of interest.

It is worth noting that genetic databases provide short summaries about genes and associated conditions, although they might not cover all possible genetic variations or provide a complete understanding of the genes and their functions. Therefore, it is important to consult additional resources and conduct further research when studying the CDT1 gene and related syndromes.

In summary, gene and variant databases such as OMIM, GeneTests, and PubMed are valuable resources for accessing information about the CDT1 gene, associated diseases, and genetic changes. These databases play a crucial role in scientific research, disease diagnosis, and genetic testing.

References

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