Filgrastim Injection

Filgrastim injection is available as several different products that are considered to be biologic medications (medications made from living organisms). These biosimilar products are highly similar to filgrastim injection and work the same way as filgrastim injection in the body. Therefore, the term filgrastim injection products will be used to represent these medications in this discussion.

🔔 Why is this medication prescribed?

Filgrastim injection products (Granix, Neupogen, Nivestym, Releuko, Zarxio) are used to decrease the chance of infection in people who have non myeloid cancer (cancer that does not involve the bone marrow) and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to fight infection). Filgrastim injection products (Neupogen, Nivestym, Releuko, Zarxio) are also used to help increase the number of white blood cells, and decrease the length of time with fever in people with acute myeloid leukemia (AML; a type of cancer of the white blood cells) who are receiving treatment with chemotherapy medications. Filgrastim injection products (Neupogen, Nivestym, Releuko, Zarxio) are also used in people who are undergoing bone marrow transplants and in people who have severe chronic neutropenia (condition in which there are a low number of neutrophils in the blood). Filgrastim injection products (Neupogen, Nivestym, Zarxio) are also used to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the body. Filgrastim injection (Neupogen) is also used to increase the chance of survival in people who have been exposed to harmful amounts of radiation, which can cause severe and life-threatening damage to your bone marrow. Filgrastim is in a class of medications called colony-stimulating factors. It works by helping the body make more neutrophils.

🔔 How should this medicine be used?

Filgrastim injection products come as a solution (liquid) in vials and prefilled syringes to be injected subcutaneously (under the skin) or to be slowly or continuously injected intravenously (into a vein). It is usually given once a day, but filgrastim injection products (Neupogen, Nivestym, Releuko, Zarxio) may be given twice a day when it is used to treat severe chronic neutropenia. The length of your treatment depends on the condition that you have and how well your body responds to the medication.

If you are using filgrastim injection products to decrease the risk of infection, decrease the time with fever, or increase the number of white blood cells during chemotherapy, you will receive your first dose of the medication at least 24 hours after you receive a dose of chemotherapy, and will continue to receive the medication every day for up to 2 weeks or until your blood cell counts return to normal. If you are using filgrastim injection products to decrease the risk of infection during a bone marrow transplant, you will receive the medication at least 24 hours after you receive chemotherapy and at least 24 hours after the bone marrow is infused. If you are using filgrastim injection products to prepare your blood for leukapheresis, you will receive your first dose at least 4 days before the first leukapheresis and will continue to receive the medication until the last leukapheresis. If you are using filgrastim injection products to treat severe chronic neutropenia, you may need to use the medication for a long period of time. If you are using filgrastim injection because you have been exposed to harmful amounts of radiation, your doctor will monitor you carefully and the length of your treatment will depend on how well your body responds to the medication. Do not stop using filgrastim injection products without talking to your doctor.

Filgrastim injection products may be given to you by a nurse or other healthcare provider, or you may be told to inject the medication under the skin at home. If you or a caregiver will be injecting filgrastim injection products at home, a healthcare provider will show you or your caregiver how to inject the medication. Be sure that you understand these directions. Ask your healthcare provider if you have any questions. Use filgrastim injection products exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Do not shake vials or syringes containing filgrastim solution. Always look at filgrastim injection products before injecting. Do not use if the expiration date has passed, or if the filgrastim solution has particles or looks foamy, cloudy, or discolored.

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Use each syringe or vial only once. Even if there is still some solution left in the syringe or vial, do not use it again. Dispose of used needles, syringes, and vials in a puncture-resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture-resistant container.

Your doctor may start you on a low dose of filgrastim injection products and gradually increase your dose. Your doctor may also decrease your dose, depending on how your body reacts to the medication.

If you are using filgrastim injection products to treat severe chronic neutropenia, you should know that this medication will control your condition but will not cure it. Continue to use filgrastim injection products even if you feel well. Do not stop using filgrastim injection products without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

🔔 Other uses for this medicine

Filgrastim injection products are also sometimes used to treat certain types of myelodysplastic syndrome (a group of conditions in which the bone marrow produces blood cells that are misshapen and does not produce enough healthy blood cells) and aplastic anemia (a condition in which the bone marrow does not make enough blood cells). Filgrastim injection products are also sometimes used to decrease the chance of infection in people who have human immunodeficiency virus (HIV) or people who are taking certain medications that decrease the number of neutrophils. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

🔔 What special precautions should I follow?

Before using filgrastim injection products,

• tell your doctor and pharmacist if you are allergic to filgrastim, pegfilgrastim (Neulasta), any other medications or any of the ingredients in filgrastim injection products. Also tell your doctor if you or the person who will be injecting filgrastim injection products (Granix, Neupogen, Zarxio) is allergic to latex.
• tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
• tell your doctor if you are being treated with radiation therapy and if you have or have ever had chronic myeloid leukemia (a slowly progressing disease in which too many white blood cells are made in the bone marrow), or myelodysplasia (problems with bone marrow cells that may develop into leukemia).
• tell your doctor if you have sickle cell disease (a blood disease that may cause painful crises, a low number of red blood cells, infection, and damage to the internal organs). If you have sickle cell disease, you may be more likely to have a crisis during your treatment with filgrastim injection products. Drink plenty of fluids during your treatment with filgrastim injection products and call your doctor right away if you have a sickle cell crisis during your treatment.
• tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using filgrastim injection products call your doctor.
• if you are having surgery, including dental surgery, tell the doctor or dentist that you are using filgrastim injection products.
• you should know that filgrastim injection products decrease the risk of infection, but do not prevent all infections that may develop during or after chemotherapy. Call your doctor if you develop signs of infection such as fever or chills, or redness, swelling, or pain around a cut or sore.
• if you get filgrastim solution on your skin, wash the area with soap and water. If filgrastim solution gets in your eye, flush your eye thoroughly with water.