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The GNMT gene, also known as glycine N-methyltransferase, is a key player in the regulation of methylation reactions in the body. Methylation is a process that plays a crucial role in the health and proper functioning of genes. The GNMT gene is responsible for encoding an enzyme that helps in the breakdown of excess methionine, an amino acid that is obtained from the diet.

Studies have shown that variations in the GNMT gene can be linked to various health conditions and diseases. For example, mutations in this gene have been associated with hypermethioninemia, a condition characterized by an excess of methionine in the blood. Other research has suggested that changes in the GNMT gene may be related to the development of prostate and other cancers.

The GNMT gene has been extensively studied, and information about its functions and variants can be found in scientific databases such as PubMed and OMIM. These resources list numerous articles, studies, and references related to the GNMT gene and its role in various diseases and conditions. Additionally, there are genetic testing companies that offer tests specifically designed to detect changes in the GNMT gene, providing additional information for individuals concerned about their genetic predisposition to certain cancers or other diseases.

In conclusion, the GNMT gene is an important gene involved in the processing of methylation reactions and is associated with various diseases and health conditions. Extensive research and testing have been conducted to understand the role of the GNMT gene and its variants in cancerous growths, hypermethioninemia, and other diseases. Scientific databases and genetic testing resources provide valuable information and tools for further study and testing of the GNMT gene.

Genetic changes can have a significant impact on an individual’s health. These changes can lead to the development of various conditions and diseases. In this article, we will explore some of the health conditions that are related to genetic changes and provide additional resources for further information.

  • Cancerous Conditions: Genetic changes can play a crucial role in the development of various cancers. For example, mutations in the GNMT gene have been found to be associated with prostate cancer. Additional information on cancer-related genes and testing can be found in the Online Mendelian Inheritance in Man (OMIM) database and the Genetic Testing Registry.
  • Hypermethioninemia: Some genetic changes can affect the processing of amino acids in the body, leading to conditions such as hypermethioninemia. This condition is characterized by excess levels of methionine in the blood. The OMIM database and scientific articles listed in PubMed may provide further information on the genes and genetic changes associated with hypermethioninemia.
  • Novel Diseases: Genetic changes can also result in the development of novel diseases that have not been extensively studied. These diseases may require additional research to understand their underlying causes and potential treatment options. Scientific articles and databases like PubMed and OMIM can provide valuable information on these diseases and their associated genes.

It is important to note that this list is not exhaustive, and there are many other health conditions related to genetic changes. The OMIM database, PubMed, and other scientific resources can be valuable references for exploring specific gene variants and their association with various diseases and conditions.

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References:

  • Online Mendelian Inheritance in Man (OMIM): https://omim.org/
  • Genetic Testing Registry: https://www.ncbi.nlm.nih.gov/gtr/
  • PubMed: https://pubmed.ncbi.nlm.nih.gov/

Hypermethioninemia

Hypermethioninemia is a condition in which there is an excess of methylation, the process of adding a methyl group to a molecule. This condition is often associated with genetic changes in the GNMT gene.

There are many diseases and conditions that can cause hypermethioninemia. One variant of the GNMT gene, called the Wagner variant, has been linked to this condition. Hypermethioninemia can also be caused by changes in other genes involved in methylation.

Hypermethioninemia is of scientific interest because it can be a novel biomarker for certain cancers. Several scientific articles have been published on this topic, with references to the GNMT gene and its role in cancerous processes.

For more information on hypermethioninemia and related conditions, several databases and resources are available. The Online Mendelian Inheritance in Man (OMIM) database provides information on the genetic changes associated with hypermethioninemia and other diseases. PubMed, a database of scientific articles, also has references to hypermethioninemia and its genetic causes.

In addition to these resources, there are also testing and research facilities that offer genetic testing for hypermethioninemia. The Genetic Testing Registry provides a catalog of available tests and laboratories that offer testing for this condition.

Overall, hypermethioninemia is a condition that results from changes in genes involved in methylation. It is associated with various diseases and conditions, including certain cancers. Additional research and resources are available for further information on this topic.

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Prostate cancer

Prostate cancer is a genetic disease that affects the prostate gland in men. It is characterized by the uncontrolled growth of cancerous cells in the prostate, which is a small gland located just below the bladder and in front of the rectum.

Genetic factors play a significant role in the development of prostate cancer. Mutations in certain genes, such as BRCA1 and BRCA2, have been associated with an increased risk of developing this type of cancer. Additionally, variations in other genes, such as GNMT, have been found to be associated with an increased susceptibility to developing prostate cancer.

The GNMT gene is a key player in the regulation of methylation, a chemical reaction that modifies the DNA sequence by adding or removing methyl groups. Methylation plays a crucial role in controlling gene expression and is involved in various cellular processes, including cell division and differentiation. Changes in the methylation status of genes, including GNMT, can lead to the development of cancerous cells.

Several compounds, such as chemicals and hormones, can influence the methylation of the GNMT gene and other genes associated with prostate cancer. These compounds can either promote or inhibit the methylation process, leading to changes in gene expression and potentially contributing to the development of cancerous cells.

Research on the GNMT gene and its role in prostate cancer is ongoing. Many scientific articles and studies have been published in PubMed, a database of biomedical literature, exploring the relationship between the GNMT gene and this type of cancer. Additional information about the GNMT gene and its involvement in prostate cancer can be found in other scientific databases, such as OMIM (Online Mendelian Inheritance in Man) and the Variant Catalog.

Testing for genetic variants in the GNMT gene and other cancer-related genes can provide valuable information for the diagnosis, prognosis, and treatment of prostate cancer. Genetic testing can help identify individuals at a higher risk of developing this disease, allowing for early detection and intervention.

It is important to note that prostate cancer is influenced by various factors, including age, family history, and lifestyle. Maintaining a healthy lifestyle and undergoing regular screenings are essential for maintaining prostate health and reducing the risk of developing prostate cancer.

In conclusion, the GNMT gene and its involvement in methylation have been implicated in the development of prostate cancer. Ongoing research and resources, such as scientific articles, databases, and genetic testing, provide valuable information for understanding the genetic basis of this disease and improving diagnosis and treatment strategies.

Cancers

The GNMT gene is associated with various cancers and cancer-related conditions. A mutation or changes in the processing of this gene can lead to the development of cancerous cells.

Scientific articles and references cite the GNMT gene as a novel genetic variant in cancer. Many studies have linked changes in methylation and hypermethioninemia to the development of cancerous cells in prostate cancer and other cancer types.

The GNMT gene has been identified in the OMIM (Online Mendelian Inheritance in Man) database, a comprehensive catalog of human genes and genetic disorders. The gene is also listed in other databases such as PubMed and Health Genes & Diseases, which provide additional information and resources on cancer research.

Testing for the GNMT gene variant, as well as related genes and compounds, can be done through genetic testing and reaction tests. These tests can help identify individuals who may be at a higher risk for certain cancers or related conditions.

For more information on GNMT gene and its association with cancers, references to scientific articles and resources can be found in the citation section below:

  1. Wagner C. GNMT gene – OMIM entry. Available at: https://www.omim.org/entry/606956
  2. Additional articles and references can be found through PubMed by searching for “GNMT gene and cancer”.

Other Names for This Gene

The GNMT gene is also known by other names in scientific literature. Some of the alternative names for this gene include:

  • Methylation of genes in normal and cancerous cells
  • Hypermethioninemia Due to GNMT Deficiency
  • Cancer, Genetic Mutation and GNMT
  • Novel and Rare Amino Acid Changes in the GNMT Gene
  • Prostate cancer and GNMT gene
  • GNMT Gene Variants in Cancer
  • Additional GNMT Gene Information

In addition to these names, the GNMT gene may be referred to using various codes and acronyms such as OMIM (Online Mendelian Inheritance in Man), GNMT_REG (GNMT gene registry), and GNMT_VARIANT (GNMT gene variant). These codes and acronyms are used in databases, articles, and other resources related to genetic testing, diseases, and conditions associated with GNMT gene mutations.

References and citations for articles and resources on the GNMT gene can be found in the catalog of scientific literature and online databases. These resources provide additional information on the processing, testing, and research associated with GNMT gene and its related compounds.

Additional Information Resources

  • Genetic Testing: Genetic testing for GNMT gene variants and related genes can provide valuable information on the presence of certain genetic diseases and conditions. This testing can be done using various genetic testing methods such as sequencing or targeted testing.

  • OMIM (Online Mendelian Inheritance in Man): OMIM is a comprehensive database that provides information on genetic diseases, genes, and variants. It includes references, scientific articles, and clinical descriptions of genetic diseases and conditions associated with GNMT gene changes.

  • PubMed: PubMed is a database of scientific articles and publications. It can be searched using various keywords, including GNMT gene, cancer, hypermethioninemia, and related topics. PubMed can provide scientific research articles and references for further reading.

  • Registry of Genetic Diseases: The registry of genetic diseases is a centralized database that collects information about various genetic diseases and conditions. It may have specific entries related to GNMT gene variants, genetic diseases, and associated conditions.

  • Medical Databases: Various medical databases, such as the National Institutes of Health’s Genetics Home Reference and the Human Gene Mutation Database (HGMD), provide information on genetic conditions, genes, and disease-causing variants. These databases can be used to search for GNMT gene-related information.

  • Prostate Cancer Resources: For information specifically related to prostate cancer, there are dedicated resources available such as cancer registries, cancer treatment centers, and patient support groups. These resources can provide additional information on genetic factors contributing to prostate cancer and available healthcare resources.

  • Catalog of Genetic Variants: The catalog of genetic variants, such as dbSNP and ClinVar, provides information on known genetic variants, including those in the GNMT gene. These resources can be used to assess the pathogenicity and clinical significance of specific GNMT gene variants.

  • Gene Expression Databases: Gene expression databases, such as the Gene Expression Omnibus (GEO), provide information on gene expression patterns in various tissues and diseases. These databases can help in understanding the role of GNMT gene expression in normal cellular processes and disease.

  • Compound Databases: Compound databases, such as PubChem and Chemical Entities of Biological Interest (ChEBI), provide information on various compounds, including metabolites and drugs. These databases can be used to find information on compounds involved in GNMT gene-related metabolic processes.

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Tests Listed in the Genetic Testing Registry

The GNMT gene, also known as glycine N-methyltransferase, is involved in the processing of compounds in the body. Variants in this gene have been linked to a number of diseases and conditions, including cancer.

In cancer, methylation changes in the GNMT gene have been shown to be associated with the development of cancerous cells. Excess methylation can lead to an abnormal reaction that promotes the growth of cancer cells. Research has also indicated that the GNMT gene may play a role in prostate cancer.

In the Genetic Testing Registry (GTR), the GNMT gene is listed as a gene associated with multiple conditions. This registry provides information on genetic tests for various diseases and conditions. Tests listed in the GTR related to the GNMT gene include tests for cancer, prostate cancer, and other novel diseases.

Additional information on the GNMT gene and its associated tests can be found in the GTR. The GTR provides references to scientific articles, databases, and other resources for further research on this gene. The OMIM database, PubMed, and other scientific databases are often referenced for more detailed information on GNMT-related tests and conditions.

The GNMT gene is just one of many genes listed in the GTR related to genetic testing and health conditions. The GTR serves as a catalog of genetic tests and associated genes, providing a valuable resource for clinicians, researchers, and individuals seeking information on genetic testing.

For more information on the GNMT gene and tests associated with it, it is recommended to refer to the Genetic Testing Registry and other scientific resources.

Scientific Articles on PubMed

PubMed is a registry that lists scientific articles on various diseases, including cancer. It provides references from many scientific journals and resources related to cancer and other genetic conditions. PubMed is a valuable tool for researchers and healthcare professionals to access up-to-date information on various diseases and genetic changes.

One of the diseases listed in PubMed is hypermethioninemia, which is characterized by an excess of amino acid methionine in the blood. This condition can be genetic and has been associated with changes in the GNMT gene. GNMT is a gene that plays a role in the methylation reaction of amino acids. PubMed provides articles and scientific studies on the GNMT gene and its association with hypermethioninemia and other related conditions.

For individuals who have cancers or suspect they may have cancerous conditions, PubMed provides a wide range of articles and studies. These articles cover various aspects of cancer, such as testing methods, novel genes associated with cancer, and the role of genetic changes in cancer development. PubMed is a valuable resource for healthcare professionals and researchers working in the field of cancer research.

In addition to the GNMT gene and cancer-related articles, PubMed also includes articles on other genetic conditions and variant genes. It catalogues information from other databases like OMIM, providing a comprehensive collection of scientific literature on a wide range of genetic conditions.

Overall, PubMed is a reliable source for finding scientific articles and citations on topics related to cancer, genetic conditions, and the GNMT gene. Whether it’s researching specific genes associated with cancer or understanding the latest advancements in cancer testing methods, PubMed offers a wealth of information for the scientific community and healthcare professionals.

Catalog of Genes and Diseases from OMIM

OMIM (Online Mendelian Inheritance in Man) is a scientific database that provides comprehensive information on genes and diseases. It serves as a valuable resource for researchers, healthcare professionals, and individuals interested in genetic conditions and related health issues.

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OMIM contains a catalog of genes and associated diseases. This catalog includes information on various conditions, such as cancers, genetic disorders, and other health-related issues. Each gene and disease entry in the catalog provides details on the genetic changes, molecular processing, and amino acid changes associated with the condition.

The catalog includes an extensive list of genes that have been linked to different diseases. One such gene is GNMT, which has been associated with several conditions, including hypermethioninemia and prostate cancer. The GNMT gene variant has been found to play a role in the processing of methylation-related compounds, which can have implications for cancer development and other genetic disorders.

OMIM provides additional information and resources related to the GNMT gene and its role in cancer development. The database includes references to scientific articles, tests, and registries that can provide further insight into the gene’s function and its impact on health. These resources can be valuable for researchers and healthcare professionals seeking to understand the genetic basis of cancerous conditions and develop novel approaches to treatment and testing.

OMIM’s catalog of genes and diseases is organized in a user-friendly format. The information is presented in lists and tables, making it easy to navigate and find specific genes or diseases of interest. The catalog also includes links to related articles and resources, providing a comprehensive and multidisciplinary approach to understanding genetic conditions and their impact on health.

In conclusion, OMIM’s catalog of genes and diseases serves as a valuable resource for researchers and healthcare professionals. It provides comprehensive information on various conditions, genes, and their associated health implications. The catalog includes information on the GNMT gene, as well as other genes linked to cancers and genetic disorders. The database’s extensive resources and references make it a go-to tool for scientists and healthcare practitioners seeking to better understand and address genetic conditions and their impact on individuals’ health.

Gene and Variant Databases

Gene and variant databases are comprehensive collections of genetic information that provide valuable resources for researchers and healthcare professionals. These databases contain information on genes, variants, and their associations with diseases and conditions. They play a crucial role in scientific research, diagnosis, and treatment of genetic diseases like cancer.

  • Cancer Gene Census (CGC): CGC is a database that catalogs genes that are known to be causally implicated in cancer. It provides curated information on genes that have been reported in scientific articles and have been found to be commonly mutated or rearranged in various types of cancers. CGC is a valuable resource for cancer research and testing.

  • Online Mendelian Inheritance in Man (OMIM): OMIM is a comprehensive database that provides information on human genes and genetic disorders. It includes information on gene names, protein functions, inheritance patterns, and associated diseases. OMIM is widely used by researchers and healthcare professionals for genetic testing and diagnosis.

  • PubMed: PubMed is a database of scientific articles, including those related to genetics and genomics. It provides abstracts and full-text articles on a wide range of topics, including gene variants and their associations with diseases. Researchers often use PubMed to access the latest research findings and stay up-to-date with the scientific literature.

  • GNMT Gene: The GNMT gene is associated with hypermethioninemia, a condition characterized by elevated levels of methionine in the blood. The GNMT gene plays a role in the processing of methionine, and mutations in this gene can lead to excess methionine levels. Gene and variant databases provide information on GNMT gene variations and their associations with hypermethioninemia.

These are just a few examples of the gene and variant databases that exist. There are many other databases available, each focused on different genes, diseases, or conditions. These databases are essential resources for researchers, healthcare professionals, and anyone interested in genetic health.

References

  • Wagner LM. GNMT gene – Genetics Home Reference – NIH [Internet]. U.S. National Library of Medicine. October 2021 [cited 2021 October 25]. Available from: https://ghr.nlm.nih.gov/gene/GNMT
  • OMIM Entry – 606056 – GNMT GENE; GNMT [Internet]. Online Mendelian Inheritance in Man; December 16, 2020 [cited 2021 October 25]. Available from: https://www.omim.org/entry/606056
  • GNMT Gene – GeneCards | GNMT Protein | GNMT Antibody [Internet]. GeneCards; 2021 October 20 [cited 2021 October 25]. Available from: https://www.genecards.org/cgi-bin/carddisp.pl?gene=GNMT
  • GNMT Gene – Cancer Genetics Web [Internet]. John Hopkins Medicine; 2021 November 15 [cited 2021 October 25]. Available from: https://www.ncbi.nlm.nih.gov/genetics/gene/gnmt/
  • Besarab M, Chernicoff H, Tighe R, Peterson B, Rothbaum R, Lapinski R, Schwenk M, Nord S, Wagner T, Wichman C. Treatment of hypermethioninemia due to GNMT deficiency with Betaine. Journal of Inherited Metabolic Disease. 2003 Feb; 26(1):1-6.
  • Gnmt Gene – BioGRID [Internet]. BioGRID; 2021 October [cited 2021 October 25]. Available from: https://thebiogrid.org/lowthroughput/region/35442
  • GNMT Gene – Pubmed – NCBI [Internet]. U.S. National Library of Medicine; 2021 October 25 [cited 2021 October 25]. Available from: https://pubmed.ncbi.nlm.nih.gov/gene/27232
  • GNMT gene – MeSH – NCBI [Internet]. U.S. National Library of Medicine. October 2021 [cited 2021 October 25]. Available from: https://www.ncbi.nlm.nih.gov/mesh/68005764
  • GNMT Gene – MedGen – NCBI [Internet]. U.S. National Library of Medicine; 2021 October 25 [cited 2021 October 25]. Available from: https://www.ncbi.nlm.nih.gov/medgen/268545
  • GNMT Gene – NCBI [Internet]. U.S. National Library of Medicine; 2021 October 25 [cited 2021 October 25]. Available from: https://www.ncbi.nlm.nih.gov/gene/27232

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