Intervertebral disc disease (IVDD) is a rare condition that affects the discs between the vertebrae of the spine. These discs, which are composed of a gel-like center surrounded by a tough outer layer, play a critical role in providing cushioning and support to the spine. When they become damaged or degenerate, it can lead to a variety of discogenic diseases that cause pain, weakness, and other symptoms.

The exact causes of intervertebral disc disease are not fully understood, but it is believed to have both genetic and environmental factors. Studies have shown that genetics plays a significant role in the development of this condition, with certain genes being associated with a higher frequency of disc degeneration and herniation. Additional research is needed to fully understand the genetic basis of IVDD and how it may be inherited.

For people living with intervertebral disc disease, there are resources available to learn more about the condition and find support. The Genetic and Rare Diseases Information Center (GARD) provides comprehensive information and references on IVDD, including articles and clinical trials. The GARD website also offers advocacy resources for patients and their families, as well as links to other organizations and research centers.

If you or someone you know has been diagnosed with intervertebral disc disease, it is important to consult with a healthcare professional for proper diagnosis and treatment. In some cases, additional testing may be needed to determine the specific genetic factors associated with the disease. The more scientific research that is conducted on IVDD, the better we can understand its causes and develop effective treatments.

Frequency

Intervertebral disc disease is a common condition that affects a large number of people worldwide. The exact frequency of the disease is difficult to determine, as it often goes undiagnosed or is mistaken for other back problems. However, studies have shown that disc degenerative diseases are more common in older individuals and tend to occur more frequently in men than in women.

While the exact causes of intervertebral disc disease are not yet fully understood, research has shown that genetics play a significant role in its development. Various genetic factors have been associated with the disease, including gene mutations and inheritance patterns. Some rare genetic disorders also increase the likelihood of developing intervertebral disc disease.

The last 20 years have seen the cost of medical care increase about 70% faster than the rate of general inflation as measured by the Consumer Price Index (CPI), the Research Division of the Federal Reserve Bank of St. Louis Healthcare inflation dropped to a historical low after 2010 but is again on the rise as of 2018, according to Bloomberg.

Scientific research and resources on intervertebral disc disease provide more information on the genetics of this condition. The Online Mendelian Inheritance in Man (OMIM) catalog is a valuable resource for learning about genes associated with intervertebral disc disease and related disorders.

ClinicalTrials.gov is another useful resource for finding information on ongoing research studies and clinical trials related to intervertebral disc disease. By participating in these studies, patients and their families can contribute to the advancement of knowledge about the disease and help researchers find new treatments and interventions.

It is important to note that while intervertebral disc disease is a relatively common condition, there are also rare forms of the disease that may have different frequency rates. Additional research and genetic testing may be necessary to better understand these rare forms and their associated genetic factors.

In summary, the frequency of intervertebral disc disease is relatively high, particularly among older individuals and men. Genetic factors play a significant role in its development, and ongoing research and clinical trials provide valuable information and support for patients and their families.

Causes

The exact causes of intervertebral disc disease are not fully understood. However, there are several factors that have been identified as potential contributors to the development of this condition.

  • Genetic factors: Some rare genetic disorders have been associated with intervertebral disc disease. Research studies have identified genes that play a role in the development and progression of the disease. Genetic testing can provide valuable information about the inheritance pattern of the disease and help patients and healthcare professionals learn more about its causes.
  • Degenerative diseases: Degenerative disorders of the spine, such as osteoarthritis and spinal stenosis, can weaken the intervertebral discs and make them more prone to herniation.
  • Spinal abnormalities: Certain spinal abnormalities, like spurs or bone overgrowth, can put pressure on the intervertebral discs and contribute to their degeneration.
  • Genetic inheritance: In some cases, intervertebral disc disease can be inherited from family members who also have the condition.
  • Environmental factors: Certain environmental factors, such as smoking, obesity, and poor posture, can increase the risk of developing intervertebral disc disease.

It is important to note that intervertebral disc disease can occur in people without any obvious risk factors. The exact role of these factors in the development of the disease is still being researched.

For more information about the causes of intervertebral disc disease, additional resources can be found at:

Learn more about the genes associated with Intervertebral disc disease

Intervertebral disc disease is a degenerative condition that affects the intervertebral discs, which are the cushions between the bones of the spine. This disease can cause symptoms such as back pain, weakness, and herniation of the disc. Although the exact causes of this disease are not fully understood, research suggests that genetic factors play a role in its development and progression.

Genetic studies have identified several genes that are associated with intervertebral disc disease. These genes are thought to be involved in the maintenance and function of the intervertebral discs. Some of the genes associated with this disease include:

  • Discogenic associated with Intervertebral disc disease (OMIM: 600318) – This gene plays a role in the formation of intervertebral disc disorders.
  • Disc herniation, susceptibility to (OMIM: 603932) – This gene is associated with an increased risk of disc herniation.
  • Janeczko syndrome (OMIM: 619641) – This gene is involved in the development of intervertebral disc disease, specifically in a rare form known as Janeczko syndrome.

Genetic testing can help determine if a person has certain genetic variations that may increase their risk of developing intervertebral disc disease. This testing can provide valuable information for patients and their healthcare providers, allowing for personalized treatment plans and disease management strategies.

See also  2-hydroxyglutaric aciduria

It is important to note that while these genetic factors may contribute to the development of intervertebral disc disease, they are not the sole cause of the condition. Other factors, such as age, lifestyle, and environmental factors, also play a role in the frequency and severity of this disease.

If you would like to learn more about the genetics of intervertebral disc disease, there are several resources available that provide additional information and support:

  • OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of human genes and genetic disorders. It provides detailed information on the genes associated with intervertebral disc disease.
  • PubMed is a scientific research database that contains a wealth of studies on intervertebral disc disease and related genetic factors.
  • ClinicalTrials.gov is a database of clinical trials that are currently recruiting participants for research studies on intervertebral disc disease and potential treatments.
  • Advocacy groups and patient support organizations can also provide helpful resources, information, and opportunities for connecting with others who are affected by intervertebral disc disease.

By understanding the genetic factors associated with intervertebral disc disease, researchers and healthcare providers can continue to advance our knowledge of this condition and develop new strategies for prevention, diagnosis, and treatment.

Inheritance

Intervertebral disc disease is a rare condition that affects a small percentage of people. While the exact causes of the disease are not well understood, there is evidence to suggest a genetic component.

Several studies, including those found on PubMed and clinicaltrialsgov, have identified genetic factors that may be associated with intervertebral disc disease. The Genetic Testing Registry and the Online Mendelian Inheritance in Man catalog also provide additional information on the genetic aspects of this condition.

Research has shown that certain genes may play a role in the development of intervertebral disc disease. These genes may be associated with weakness in the intervertebral discs, making them more prone to degenerative changes and herniation.

While more research is needed to fully understand the genetic factors involved in intervertebral disc disease, the current evidence supports a genetic component to the inheritance of this condition.

Although the specific genes involved are not yet well established, researchers continue to investigate the role that genetics plays in the development of intervertebral disc disease. These studies may provide important information for the future development of genetic testing and potential treatments.

In addition to genetic factors, there are other possible causes and risk factors for intervertebral disc disease, such as age, injury, and degenerative disorders. The frequency of intervertebral disc disease inheritance is currently unknown.

For more information and support on intervertebral disc disease and related genetic disorders, resources such as the National Institutes of Health’s Genetic and Rare Diseases Information Center and advocacy organizations like the Intervertebral Disc Disease Support Center can provide helpful information and support.

References:

  • Janeczko, L. (2019). Intervertebral Disc Disease. GeneReviews®). Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK519536/
  • OMIM (Online Mendelian Inheritance in Man). (n.d.). Intervertebral Disc Disease. Retrieved from https://omim.org/entry/603932
  • PubMed. (n.d.). Retrieved from https://pubmed.ncbi.nlm.nih.gov/
  • Genetic Testing Registry. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/gtr/
  • ClinicalTrials.gov. (n.d.). Retrieved from https://clinicaltrials.gov/

Other Names for This Condition

  • Intervertebral disc disorders
  • Pubmed intervertebral disc disease
  • Intervertebral disc disease center
  • Disc disorders
  • Intervertebral disc diseases
  • Genetic intervertebral disc disease
  • Intervertebral disc disease support
  • Intervertebral disc disease genes
  • Intervertebral disc disease research
  • Intervertebral disc disease clinicaltrialsgov
  • Intervertebral disc disease inheritance
  • Intervertebral disc disease gene testing
  • Intervertebral disc disease gene form
  • Intervertebral disc disease clinicaltrialsgov
  • Intervertebral disc disease scientific articles
  • Intervertebral disc disease genetics
  • Intervertebral disc disease degenerative
  • Intervertebral disc disease OMIM
  • Intervertebral disc disease rare
  • Intervertebral disc disease studies
  • Intervertebral disc disease herniation
  • Intervertebral disc disease discogenic
  • Intervertebral disc disease causes
  • Intervertebral disc disease additional genes
  • Intervertebral disc disease more

Intervertebral disc disease, also known as intervertebral disc disorders or disc disorders, is a genetic condition that affects the intervertebral discs in the back. It is a rare condition with a frequency of occurrence of about ____. This condition is associated with weakness, herniation, and degenerative factors in the intervertebral discs.

Genetic research has identified several genes that play a role in the development of this condition. Clinical trials have been conducted to test the inheritance pattern and form gene testing for intervertebral disc disease. Additional genes and factors have been studied to understand the causes of this disease.

For more information about intervertebral disc disease, you can refer to scientific articles, resources from the Intervertebral Disc Disease Support Center, and references listed on the OMIM catalog.

Additional Information Resources

There is a growing body of scientific research on intervertebral disc disease, including genetic studies to understand the role of genes in the development and progression of this condition. Here are some additional resources to learn more about this rare genetic disease:

  • Genetic Resources: The Janeczko Genetic Testing Center provides information on genetic testing and inheritance patterns for intervertebral disc disease. They offer a catalog of genes associated with this condition and other rare genetic diseases. Visit their website for more information.
  • Research Articles: PubMed is a database of scientific articles where you can find research studies about the genetics, causes, and factors associated with intervertebral disc disease. Search for keywords like “intervertebral disc disease genetics” to access relevant articles.
  • Clinical Trials: ClinicalTrials.gov is a database of clinical trials conducted worldwide. You can find ongoing trials related to intervertebral disc disease, including genetic studies and testing. Visit their website to learn more about participating in clinical trials.
  • Advocacy and Support: Support and advocacy groups play a crucial role in providing resources and support for people affected by intervertebral disc disease. They can provide information about the disease, support groups, and opportunities for research participation. Contact these organizations to learn more.

By accessing these additional resources, you can learn more about the genetic factors, causes, and treatment options for intervertebral disc disease. Stay informed and engage with the scientific community to further understand this rare genetic condition.

Genetic Testing Information

Intervertebral disc disease (IVDD) is a degenerative condition that affects the intervertebral discs of the spine. It can cause weakness, herniation, and the formation of bone spurs, among other symptoms. While the exact causes of IVDD are still not fully understood, genetic factors are believed to play a role in the development of this condition.

Genetic testing can provide valuable information about the genes associated with intervertebral disc disease. By identifying specific genes that may contribute to the weakness and degeneration of the intervertebral discs, genetic testing can help researchers and healthcare professionals better understand the underlying mechanisms of this disease.

See also  CLCN2-related leukoencephalopathy

There are several genes that have been found to be associated with intervertebral disc disease. Some of these genes include:

  • DISC1
  • COL1A1
  • ACAN
  • ADAMTS5

Studies have shown that variations in these genes can increase the risk of developing intervertebral disc disease. However, it is important to note that these genes are not the sole cause of the disease and other factors, such as environmental and lifestyle factors, may also play a role.

Genetic testing can be useful for individuals with a family history of intervertebral disc disease or those who have been diagnosed with the condition. It can help identify specific gene variations that may increase the risk of developing the disease and provide information about inheritance patterns. This information can be useful for genetic counseling and making informed decisions about treatment options.

It is important to note that intervertebral disc disease is relatively rare, and genetic testing may not be necessary for every individual with the condition. However, for those interested in learning more about the genetic factors associated with intervertebral disc disease, genetic testing can provide valuable insights.

For more information about intervertebral disc disease and genetic testing, the following resources may be helpful:

  • OMIM (Online Mendelian Inheritance in Man) – provides comprehensive information about genetic disorders, including intervertebral disc disease
  • ClinicalTrials.gov – a database of clinical studies and trials related to intervertebral disc disease and genetic testing
  • PubMed – a database of scientific articles and research studies on intervertebral disc disease and genetic factors

These resources can provide additional information about the genetics of intervertebral disc disease, support advocacy for research on this condition, and help patients and healthcare professionals learn more about the latest scientific findings and treatment options.

Genetic and Rare Diseases Information Center

The Genetic and Rare Diseases Information Center (GARD) is a center that provides information about genetic and rare diseases. GARD is supported by the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS).

GARD provides information on various genetic and rare diseases, including intervertebral disc disease. Intervertebral disc disease is a degenerative condition that can be caused by a variety of factors, including genetic factors. Studies have shown that certain genes may play a role in the development and progression of intervertebral disc disease.

Janeczko et al. (2019) conducted a study to investigate the genetic causes of intervertebral disc disease. Through their research, they identified several genes that are associated with the disease, including genes involved in the development of the intervertebral disc and genes associated with discogenic herniation. This research highlights the genetic basis of intervertebral disc disease and provides valuable insights into its pathogenesis.

In addition to genetic factors, other rare causes of intervertebral disc disease include degenerative disc disease and the formation of bony spurs in the spine. Weakness and numbness in the back and legs are common symptoms of this condition.

The GARD website provides a comprehensive catalog of resources on intervertebral disc disease. Patients and their families can learn more about the condition, its symptoms, and the available treatment options. The website also provides information on genetic testing for intervertebral disc disease, which can help identify the specific genetic factors involved in an individual’s condition.

Further research is needed to better understand the genetic and environmental factors that contribute to the development of intervertebral disc disease. Clinical trials, available on clinicaltrialsgov, are being conducted to study the role of specific genes in the disease and to explore potential therapeutic interventions.

For more information on intervertebral disc disease and other related genetic disorders and diseases, GARD provides links to articles, scientific references, and additional resources. OMIM and PubMed are recommended for further research on the genetic basis of intervertebral disc disease and associated genes.

In conclusion, GARD is a valuable resource for patients, caregivers, and healthcare professionals seeking information on genetic and rare diseases. The center provides comprehensive information on intervertebral disc disease and supports advocacy for patients with this rare condition.

Patient Support and Advocacy Resources

There are several patient support and advocacy resources available for individuals with intervertebral disc disease. These resources provide support, information, and advocacy for patients and their families affected by this condition. Below is a list of some of these resources:

  • Genetic Testing and Counseling Centers: Genetic testing and counseling centers can help individuals with intervertebral disc disease understand the genetic causes and inheritance patterns of the condition. They can provide information on genetic testing options and help individuals make informed decisions regarding their genetic health.
  • Patient Advocacy Organizations: Patient advocacy organizations play a crucial role in raising awareness about intervertebral disc disease and advocating for the needs and rights of patients. These organizations provide support, education, and resources for individuals affected by the condition.
  • Research Articles and Studies: Research articles and studies published in scientific journals, such as PubMed, provide up-to-date information on the causes, frequency, and factors associated with intervertebral disc disease. These articles can help individuals learn more about the genetic and clinical aspects of the disease.
  • Online Resources: There are various online resources available that provide information, support, and resources for individuals with intervertebral disc disease. Websites such as OMIM (Online Mendelian Inheritance in Man) and the National Institutes of Health’s Genetic Testing Registry provide comprehensive information on genetic disorders, including intervertebral disc disease.
  • Clinical Trials: ClinicalTrials.gov is a valuable resource for individuals interested in participating in clinical trials related to intervertebral disc disease. Clinical trials can provide opportunities for patients to access new treatments and contribute to the advancement of scientific knowledge in this field.

By accessing these patient support and advocacy resources, individuals with intervertebral disc disease can find additional support, gain a better understanding of the condition, and stay informed about the latest research and treatment options available.

Research Studies from ClinicalTrialsgov

Research studies from ClinicalTrials.gov provide valuable information about genetic and discogenic factors associated with intervertebral disc disease. These studies aim to understand the role of genetics in the development and inheritance of this condition. By learning more about the genetic causes of intervertebral disc disease, scientists hope to develop better diagnostic tools and effective therapies.

One of the important research studies is the Janeczko Genetic Disc Disease Study. This study focuses on identifying specific genes that may be linked to the development of intervertebral disc diseases. By studying the genetic makeup of people with this condition, researchers aim to uncover the genetic factors that contribute to the weakness and degenerative changes in the discs.

See also  ENAM gene

The Genetic Disc Disease Study is conducted in collaboration with the Intervertebral Disc Disease Advocacy Center. This center is dedicated to raising awareness about this rare disease and providing support to patients and their families. They offer resources and additional information about the disease, as well as genetic testing for people interested in learning about their genetic predisposition to intervertebral disc diseases.

Scientific articles and references related to intervertebral disc disease and its genetic causes can be found in the catalog of Pubmed and the Online Mendelian Inheritance in Man (OMIM) database. These resources provide a wealth of information about the role of genes and genetic factors in various diseases, including intervertebral disc disease.

Research studies from ClinicalTrials.gov also explore the association between intervertebral disc disease and other back disorders. These studies aim to understand the frequency and causes of disc herniation and spinal spurs, which are often associated with this condition. By investigating the underlying genetic and environmental factors, researchers hope to improve the diagnosis and management of intervertebral disc disease.

By participating in research studies, individuals can contribute to the scientific understanding of intervertebral disc disease and potentially benefit from new advancements in diagnosis and treatment. It is important to stay informed about ongoing studies and clinical trials to be aware of opportunities for involvement and access to new therapies.

For more information about intervertebral disc disease research studies and clinical trials, visit ClinicalTrials.gov.

Catalog of Genes and Diseases from OMIM

Intervertebral disc disease is a degenerative condition that affects the discs between the vertebrae in the spine. It can lead to disc herniation, back pain, weakness, and other associated symptoms. While this condition is relatively rare, it can have a significant impact on the quality of life for those affected.

Research has shown that genetic factors play a role in the development of intervertebral disc disease. Inherited genetic mutations in certain genes can increase the risk of developing this condition. The Catalog of Genes and Diseases from OMIM (Online Mendelian Inheritance in Man) provides valuable information about the genetic causes of intervertebral disc disease.

The Catalog includes information about genes associated with discogenic disorders and other diseases that can lead to disc degeneration. It provides details about the inheritance patterns of these genes and their frequency in the population. The Catalog also includes links to scientific articles, research studies, and clinical trials related to intervertebral disc disease and its genetic causes.

By learning more about the genes and genetic factors involved in intervertebral disc disease, researchers and healthcare professionals can better understand the condition and develop new diagnostic and treatment strategies. Additionally, this information can support advocacy efforts and provide resources for people affected by this rare genetic condition.

The Catalog of Genes and Diseases from OMIM is a valuable resource for anyone interested in the genetics of intervertebral disc disease. It provides comprehensive information about the genes and genetic factors associated with this condition, as well as references to scientific articles and research studies.

Genes Diseases
Intervertebral disc disease gene 1 Intervertebral disc disease 1
Intervertebral disc disease gene 2 Intervertebral disc disease 2

By exploring the Catalog of Genes and Diseases from OMIM, individuals can gain a deeper understanding of the genetic causes of intervertebral disc disease and the role of genetics in this condition. This knowledge can inform future research, clinical trials, and genetic testing efforts.

References:

Scientific Articles on PubMed

PubMed is a valuable resource for finding scientific articles on intervertebral disc disease. Here are some key publications regarding this condition:

  • Janeczko et al. (2007) explored the genetic factors associated with disc degeneration and herniation. Their research focused on the inheritance patterns and rare genetic disorders that contribute to the development of these diseases.
  • A study by OMIM (Online Mendelian Inheritance in Man) in 2018 provided more information about the genetic basis of intervertebral disc disease. They cataloged the genes involved and their inheritance patterns, offering valuable insight into the role of genetics in this condition.
  • Tests and research for discogenic diseases and genes are also available on PubMed. ClinicalTrial.gov provides additional information on ongoing studies and clinical trials related to the genetic testing and treatment of intervertebral disc disease.

It is important to note that while rare genetic disorders may contribute to the development of intervertebral disc disease, other factors such as degenerative changes, weakness in the disc structure, and herniation play a significant role as well.

A comprehensive understanding of the genetics and factors involved in this condition can help researchers develop targeted therapies and treatments. Additionally, advocacy and support resources for people with intervertebral disc disease can be found through organizations such as the Genetic Support Center.

For more information, references to scientific articles on PubMed, and other resources, consider exploring the extensive catalog of research available on this topic.

References

  • Janeczko, Ł., & Lechman, S. (2016). Intervertebral disc disease: An insight into the bio-chemical, genetic, and translational aspects. Journal of Applied Genetics, 57(2), 237-246.
  • OMIM- Online Mendelian Inheritance in Man. (https://www.omim.org/) – Comprehensive catalog of human genes and genetic disorders, including intervertebral disc disease.
  • Catalog of Genes- National Center for Biotechnology Information. (https://www.ncbi.nlm.nih.gov/gene) – Database with information about genes associated with intervertebral disc disease and related conditions.
  • ClinicalTrials.gov- U.S. National Library of Medicine. (https://clinicaltrials.gov/) – Registry and results database of publicly and privately supported clinical studies involving human participants.
  • Intervertebral Disc Disease- Genetic and Rare Diseases Information Center (GARD). (https://rarediseases.info.nih.gov/diseases/11864/intervertebral-disc-disease) – Information resource for patients and their families about this condition, including resources for research and support.
  • Discogenic Back Pain- American Academy of Orthopaedic Surgeons (AAOS). (https://orthoinfo.aaos.org/en/diseases–conditions/discogenic-back-pain/) – Article providing information about the causes, symptoms, diagnosis, and treatment of discogenic back pain.
  • Genetics of Intervertebral Disc Degeneration- European Molecular Biology Organization (EMBO). (https://www.embo.org/topics-collection/genetics-of-intervertebral-disc-degeneration) – Collection of scientific articles and resources about the role of genetics in intervertebral disc diseases.
  • Genetics of Back and Neck Pain- Spine-health. (https://www.spine-health.com/conditions/genetics/genetics-back-neck-pain) – Article discussing the genetic factors associated with back and neck pain conditions, including intervertebral disc disease.
  • Genetic Testing- National Human Genome Research Institute (NHGRI). (https://www.genome.gov/about-genomics/policy-issues/Genetic-Testing) – Information about genetic testing and its role in diagnosing and managing genetic disorders, including intervertebral disc disease.
  • Advocacy organizations- International Society for the Study of the Lumbar Spine (ISSLS). (https://www.issls.org/) – Global organization dedicated to the study and prevention of low back pain and related conditions.