The HLA-DPB1 gene is one of the genes listed under the HLA-DP gene complex. It plays a crucial role in the immune system and is associated with various health conditions. This article provides scientific information, resources, and references related to the HLA-DPB1 gene and its genetic variants.

HLA-DPB1 gene changes and variants can trigger different disorders and diseases, such as rheumatoid arthritis and juvenile idiopathic arthritis. Additional tests and genetic testing can be done to determine the presence of specific HLA-DPB1 variants associated with these conditions.

In the field of medical research, databases like PubMed and other health resources provide articles, references, and information on the HLA-DPB1 gene and its role in various diseases. The HLA-DPB1 gene is involved in the production of human leukocyte antigen (HLA) proteins, which play a major role in immune responses and protecting the body from diseases.

The HLA-DPB1 gene is a part of the HLA class II genes, which are important for immune system function. It is included in the HLA-DP gene complex, along with several other genes. The gross changes in this gene can lead to a complex interplay of genetic factors related to different diseases and conditions.

There are specific HLA-DPB1 gene variants that have been identified as being associated with certain diseases, such as HLA-DPB1*01:01 and juvenile idiopathic arthritis. These variants have been recorded in the HLA Gene and Allele Frequency Database, providing valuable information for research and clinical purposes.

In conclusion, the HLA-DPB1 gene and its variants are significant in understanding the genetic aspects of various diseases and conditions, particularly those related to the immune system. Studying this gene and its changes can contribute to advancements in diagnostics, treatment options, and overall health outcomes.

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The HLA-DPB1 gene plays a role in the body’s immune system and is associated with various health conditions. This gene is commonly studied and researched in the context of genetic changes that can impact an individual’s susceptibility to diseases and disorders.

Information about genetic changes in the HLA-DPB1 gene can be found in databases such as OMIM (Online Mendelian Inheritance in Man), which provides comprehensive resources for researchers and healthcare professionals. These resources contain information on various conditions associated with changes in the HLA-DPB1 gene.

One of the health conditions related to genetic changes in the HLA-DPB1 gene is juvenile idiopathic arthritis. Research has shown that certain variants of the HLA-DPB1 gene are associated with an increased risk of developing this form of arthritis.

Another health condition in which genetic changes in the HLA-DPB1 gene may play a role is granulomatosis with polyangiitis (GPA). Studies have found that specific changes in the HLA-DPB1 gene can trigger an immune response leading to GPA.

Rheumatoid arthritis, a chronic inflammatory disorder, is also related to genetic changes in the HLA-DPB1 gene. Certain variants of this gene have been associated with an increased risk of developing rheumatoid arthritis.

Testing for genetic changes in the HLA-DPB1 gene can provide valuable information for individuals who suspect they may be at risk for these and other associated conditions. The results of such tests can be used by healthcare professionals to provide appropriate diagnosis and treatment options.

References to scientific articles and additional information can be found in databases such as PubMed. These resources offer a wealth of information on the genetic changes and related health conditions associated with the HLA-DPB1 gene.

In conclusion, the HLA-DPB1 gene is involved in various complex diseases and disorders. Genetic changes in this gene can increase an individual’s susceptibility to conditions such as juvenile idiopathic arthritis, granulomatosis with polyangiitis, and rheumatoid arthritis. Testing for these genetic changes can provide valuable information for diagnosis and treatment.

Granulomatosis with polyangiitis

Granulomatosis with polyangiitis (GPA), also known as Wegener’s granulomatosis, is a rare autoimmune disorder that affects blood vessels. It is characterized by the formation of granulomas, inflammation, and tissue damage in various organs, typically affecting the upper respiratory tract, lungs, and kidneys.

GPA is thought to have a genetic component, and the HLA-DPB1 gene plays a crucial role in the development and progression of the disease. The HLA-DPB1 gene is a part of the human leukocyte antigen (HLA) complex, which plays a key role in the immune system. It encodes for proteins that are involved in presenting antigens to immune cells, thus triggering an immune response.

Several genetic variants of the HLA-DPB1 gene have been associated with an increased risk of developing GPA. These variants can lead to changes in the structure and function of the HLA-DP proteins, which may contribute to the development of the condition.

Testing for HLA-DPB1 gene variants can be useful in the diagnosis of GPA and may help differentiate it from other related diseases. Testing can be performed using various methods, including genetic sequencing and analysis.

References to the HLA-DPB1 gene and its association with GPA can be found in scientific articles, databases, and resources such as OMIM (Online Mendelian Inheritance in Man) and PubMed. These resources provide additional information on the genetic changes and variants associated with the gene, as well as related disorders.

The HLA-DPB1 gene is listed in genetic catalogs and registries, which provide a comprehensive catalog of genetic variants and their associated diseases and conditions. This information can be used by healthcare professionals and researchers to better understand the genetic basis of GPA and develop targeted therapies.

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In addition to GPA, the HLA-DPB1 gene has also been associated with other autoimmune and inflammatory conditions, such as rheumatoid arthritis and juvenile idiopathic arthritis. These conditions share similar genetic changes and may have overlapping clinical features.

Testing for HLA-DPB1 gene variants can also be important in identifying potential triggers for autoimmune diseases and understanding the role of genetic factors in their development. By identifying specific genes and genetic changes, scientists and researchers can gain insights into the underlying mechanisms of these conditions and develop more effective treatments.

Resources:

  • OMIM (Online Mendelian Inheritance in Man) – Provides comprehensive information on genetic disorders and associated genes.
  • PubMed – a database of scientific articles and publications on various topics, including genetics and autoimmune diseases.
  • Genetic catalogs and registries – compile information on genetic variants and their associated diseases and conditions.

Genes related to granulomatosis with polyangiitis:
Gene Name Gene Symbol
HLA-DPB1 HLA-DPB1

Juvenile idiopathic arthritis

Juvenile idiopathic arthritis (JIA) is a complex group of disorders that affect children and adolescents. It is characterized by chronic joint inflammation, which can result in joint damage and disability. The exact cause of JIA is unknown, but it is believed to involve a combination of genetic and environmental factors.

The HLA-DPB1 gene, also known as the “DPB1 gene,” has been implicated in JIA and other autoimmune diseases. The HLA-DPB1 gene is responsible for encoding proteins that play a role in the immune system. Variants of the HLA-DPB1 gene have been associated with an increased risk of developing JIA.

Genetic testing for HLA-DPB1 gene variants can be useful in diagnosing JIA and determining its severity. There are several tests available that can detect changes in the HLA-DPB1 gene. These tests can be performed using a simple blood sample.

In addition to JIA, variants in the HLA-DPB1 gene have been linked to other autoimmune diseases, such as rheumatoid arthritis and polyangiitis granulomatosis. Understanding the genetic changes in the HLA-DPB1 gene can provide important information about the underlying causes of these conditions.

There are several databases and resources available that provide genetic information on the HLA-DPB1 gene and its variants. The OMIM database and PubMed are scientific resources that contain articles related to the HLA-DPB1 gene and its association with various diseases.

The HLA-DPB1 gene is listed in the GeneCards and Entrez Gene databases, which provide additional information on the gene and its functions. The HLA-DPB1 gene is also included in genetic testing panels and registries, such as the Genetic Testing Registry, which offer tests specifically designed to detect variants in this gene.

In summary, the HLA-DPB1 gene plays a role in the development of juvenile idiopathic arthritis and other autoimmune diseases. Genetic testing for variants in this gene can provide important information for diagnosis and treatment. Several databases and resources are available to access genetic information on the HLA-DPB1 gene.

Rheumatoid arthritis

Rheumatoid arthritis is a chronic autoimmune disorder that primarily affects the joints. It is characterized by inflammation, swelling, and pain in the affected joints. The exact cause of rheumatoid arthritis is still unknown, but it is believed to involve a combination of genetic and environmental factors.

One gene that has been found to play a role in the development of rheumatoid arthritis is the HLA-DPB1 gene. This gene encodes proteins that are part of the HLA-DP complex, which is involved in the body’s immune response. Variants of the HLA-DPB1 gene have been associated with an increased risk of developing rheumatoid arthritis.

To better understand the genetic basis of rheumatoid arthritis, researchers have created a catalog of genetic variants and related genes that may be involved in the development of the condition. This catalog, called the OMIM database, provides comprehensive information on the genetic basis of various disorders, including rheumatoid arthritis.

Scientists have conducted various studies and tests, such as genome-wide association studies, to identify additional genes that may be associated with rheumatoid arthritis. These studies have identified several genetic variants in genes other than HLA-DPB1 that may increase the risk of developing the condition.

In addition to rheumatoid arthritis, the HLA-DPB1 gene and its variants have also been associated with other autoimmune conditions, such as juvenile idiopathic arthritis, human beta granulomatosis, and polyangiitis. These findings suggest that there may be shared genetic factors involved in the development of these conditions.

Testing for genetic variants in the HLA-DPB1 gene and related genes can provide important information about an individual’s genetic risk for developing rheumatoid arthritis and other related conditions. This information can be used for early detection, monitoring, and personalized treatment plans for individuals at risk.

References:

  1. “HLA-DP.” OMIM, Johns Hopkins University, www.ncbi.nlm.nih.gov/omim/142855. Accessed 1 Oct. 2021.
  2. “Rheumatoid arthritis.” Genetics Home Reference, U.S. National Library of Medicine, ghr.nlm.nih.gov/condition/rheumatoid-arthritis. Accessed 1 Oct. 2021.
  3. “Genetics of Rheumatoid Arthritis.” PubMed, pubmed.ncbi.nlm.nih.gov/32474137/. Accessed 1 Oct. 2021.

Other disorders

In addition to the conditions listed above, the HLA-DPB1 gene has been implicated in other disorders and health conditions. Research has shown that specific HLA-DPB1 gene variants are associated with an increased risk of developing certain diseases, including:

  • Rheumatoid arthritis: Studies have found a link between certain HLA-DPB1 gene variants and an increased risk of developing rheumatoid arthritis, an autoimmune disorder that affects the joints.
  • Juvenile idiopathic arthritis: Similar to rheumatoid arthritis, certain HLA-DPB1 gene variants are associated with an increased risk of developing juvenile idiopathic arthritis, a form of arthritis that occurs in children and adolescents.
  • Granulomatosis with polyangiitis: Studies have found an association between specific HLA-DPB1 gene variants and an increased risk of developing granulomatosis with polyangiitis, a rare autoimmune disease that affects the blood vessels.
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These genetic variants in the HLA-DPB1 gene can trigger changes in the proteins it produces, which can have an impact on the immune system and contribute to the development of these conditions. Understanding the role of HLA-DPB1 gene variants in these diseases is still an active area of scientific research.

For additional information on genetic testing and gene-related databases, resources such as OMIM (Online Mendelian Inheritance in Man) and PubMed can provide further references and articles on the HLA-DPB1 gene and related conditions.

Other Names for This Gene

The HLA-DPB1 gene, also known as the “Human Leukocyte Antigen DP Beta-1 Chain” gene, has several other names that are commonly used in scientific literature and databases. These names include:

  • Rheumatoid Related Antigen-DPβ1 Gene
  • HLDG
  • Major Histocompatibility Complex Class II DP Beta 1
  • DPB1
  • HLA-DPB
  • HLA-DP

These alternative names are used when referring to this gene in articles, scientific research, and databases such as PubMed, OMIM, and the HLA registry. The HLA-DPB1 gene plays a critical role in the immune system, particularly in the context of autoimmune diseases and the body’s response to infection.

Research has shown that changes or variants in the HLA-DPB1 gene can increase the risk of developing certain diseases. For example, specific changes in this gene have been associated with an increased risk of developing rheumatoid arthritis, juvenile idiopathic arthritis, and granulomatosis with polyangiitis. Additionally, this gene has been found to be related to other disorders, with variations in HLA-DPB1 being listed as a genetic risk factor for various conditions.

Genetic testing and analysis of the HLA-DPB1 gene are often conducted to assess an individual’s susceptibility to certain diseases or determine the compatibility of organ transplantation. The information obtained from testing and research on this gene provides valuable insights into the genetic basis and underlying mechanisms of these diseases.

In conclusion, the HLA-DPB1 gene, with its various names and related diseases, plays a significant role in autoimmune disorders, rheumatoid arthritis, and other conditions. The scientific community relies on resources such as databases, research articles, and genetic testing to understand the impact of gene changes and variants in HLA-DPB1 and related genes and proteins.

Additional Information Resources

For more information on HLA-DPB1 gene and related conditions, the following resources are available:

  • Polyangiitis: This disorder is sometimes referred to by other names, such as granulomatosis with polyangiitis (GPA) or Wegener’s granulomatosis. It is a type of autoimmune disease that affects blood vessels.
  • Genetic Catalog and Registry: The Genetic Testing Registry (GTR) provides information about genetic tests for various conditions, including HLA-DPB1 related disorders.
  • DPB1 Gene: This article provides detailed information about the HLA-DPB1 gene and its role in human diseases, including rheumatoid arthritis and idiopathic inflammatory myopathies.
  • HLA-DPB1 Variants: This article discusses the different variants of the HLA-DPB1 gene and their association with various autoimmune and inflammatory conditions.
  • HLA-DPB1 Testing: Information on genetic testing for HLA-DPB1 gene variants and their role in disease susceptibility can be found in this resource.
  • OMIM: Online Mendelian Inheritance in Man (OMIM) is a comprehensive database that provides information on genetic disorders and associated genes. The HLA-DPB1 gene is listed in the OMIM database.
  • PubMed: PubMed is a scientific database that contains a vast collection of articles related to various genetic and health-related topics. Searching for “HLA-DPB1 gene” or related terms in PubMed can provide additional scientific articles.

Tests Listed in the Genetic Testing Registry

The Genetic Testing Registry (GTR) provides resources for genetic testing, including information on diseases and complex conditions associated with the HLA-DPB1 gene. The HLA-DPB1 gene is closely related to various disorders such as rheumatoid arthritis and granulomatosis with polyangiitis. Genetic testing plays a crucial role in identifying changes in this gene and other related genes, which may trigger the development of these conditions.

The GTR catalogs a wide range of genetic tests that are available for investigating changes in the HLA-DPB1 gene. These tests can help increase understanding of the genetic variants associated with different diseases and provide valuable information for scientific research.

One example of a genetic test listed in the GTR is the Juvenile Idiopathic Arthritis – HLA-DPB1 Gene Variant test. This test is designed to identify specific changes in the HLA-DPB1 gene that may be associated with the development of juvenile idiopathic arthritis. Information about this test, including its purpose, methodology, and references, can be found in the GTR.

In addition to the HLA-DPB1 gene, the GTR also provides information on other genes and genetic tests related to various disorders. For example, genetic tests for rheumatoid arthritis and granulomatosis with polyangiitis can be found in the GTR, along with information on the associated genes and variants.

The GTR serves as a valuable resource for healthcare professionals, researchers, and individuals interested in genetic testing. It offers a comprehensive catalog of tests and related information, including references to scientific articles and databases such as OMIM and PubMed, that can help increase knowledge and understanding of genetic conditions and their underlying causes.

Examples of Genetic Tests Listed in the Genetic Testing Registry
Test Name Conditions/Diseases Associated Genes
Juvenile Idiopathic Arthritis – HLA-DPB1 Gene Variant Juvenile Idiopathic Arthritis HLA-DPB1
Rheumatoid Arthritis Genetic Risk Rheumatoid Arthritis Multiple genes
Granulomatosis with Polyangiitis Genetic Risk Granulomatosis with Polyangiitis Multiple genes

These examples demonstrate how genetic testing can provide important information about genetic changes associated with various conditions. By identifying specific variants in genes like HLA-DPB1, healthcare professionals can offer more personalized care and develop targeted treatment strategies for individuals with these disorders.

Scientific Articles on PubMed

PubMed is a popular database that provides a vast collection of scientific articles on various topics. A search for the term “HLA-DPB1 gene” in PubMed yields numerous articles related to this gene and its various aspects. These articles cover a wide range of topics, from the complex changes that the gene undergoes to the role it plays in the body’s immune response.

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The HLA-DPB1 gene has several variants, and these articles catalog the different variants and their associations with various diseases. For example, some studies explore the relationship between HLA-DPB1 variants and diseases such as granulomatosis with polyangiitis and rheumatoid arthritis.

Additionally, the articles listed in PubMed provide references to other databases and resources that offer more information about the HLA-DPB1 gene and related conditions. These resources include the Online Mendelian Inheritance in Man (OMIM), which provides a comprehensive catalog of genetic disorders and associated genes.

Testing for HLA-DPB1 gene variants is available in health clinics, and these articles discuss the significance of such testing. They highlight that HLA-DPB1 gene testing can help identify individuals at risk for certain conditions and aid in their diagnosis and treatment.

In the field of rheumatology, the HLA-DPB1 gene has been extensively studied due to its association with various autoimmune disorders such as rheumatoid arthritis, juvenile idiopathic arthritis, and granulomatosis with polyangiitis. Scientists have identified specific HLA-DPB1 gene variants that can trigger these disorders.

The scientific articles on PubMed provide valuable insights into the genetic basis of these conditions and offer potential avenues for further research and development of diagnostic tests and treatments.

In conclusion, PubMed is a valuable resource for accessing scientific articles on the HLA-DPB1 gene and related topics. Researchers and healthcare professionals can benefit from the wealth of information available in these articles and the references to additional genetic databases and resources.

Catalog of Genes and Diseases from OMIM

The OMIM (Online Mendelian Inheritance in Man) catalog provides information on genetic variants, genes, and associated diseases. It serves as a comprehensive registry for genetic conditions and offers a valuable resource for researchers and healthcare professionals.

For the HLA-DPB1 gene, the OMIM catalog provides information on various changes and variants associated with different diseases. These genetic changes can lead to conditions such as rheumatoid arthritis, juvenile idiopathic arthritis, and granulomatosis with polyangiitis.

The catalog lists the names of the gene and its variants, along with references to scientific articles and databases such as PubMed. It also provides additional resources for genetic testing and information on the role the gene plays in the body’s immune response.

Healthcare professionals can use the OMIM catalog to access detailed information on specific genetic variations and their associated diseases. The catalog includes data on protein changes, beta-awrning impact, and other relevant factors related to these conditions.

Gene Disease
HLA-DPB1 Rheumatoid arthritis
HLA-DPB1 Juvenile idiopathic arthritis
HLA-DPB1 Granulomatosis with polyangiitis

The OMIM catalog is constantly updated with new information and discoveries in the field of genetics. It serves as a valuable resource for geneticists and clinicians who are involved in diagnosing and treating patients with genetic disorders.

  • Access to detailed information on genetic variants and associated diseases
  • References to scientific articles and databases like PubMed
  • Additional resources for genetic testing
  • Data on protein changes and their impact on health
  • Information on the role of genes in specific conditions

In summary, the OMIM catalog provides a comprehensive overview of genes and diseases, including the HLA-DPB1 gene and its related conditions. It serves as a valuable tool for genetic research, testing, and diagnosis.

Gene and Variant Databases

Gene and variant databases are valuable resources for researchers, clinicians, and individuals interested in understanding the genetic basis of various diseases. These databases contain information about genes, their variants, and their associations with specific diseases.

One example of a gene and variant database is the Online Mendelian Inheritance in Man (OMIM) database. OMIM provides a comprehensive catalog of genes and genetic disorders, including juvenile idiopathic arthritis and rheumatoid arthritis. It also contains information on the HLA-DPB1 gene and its variants.

Another database that includes information on the HLA-DPB1 gene is the Human Gene Mutation Database (HGMD). HGMD is a resource that collects and curates information on genetic mutations associated with various diseases. It includes information on genetic variants in the HLA-DPB1 gene that may be related to diseases such as rheumatoid arthritis and granulomatosis with polyangiitis.

In addition to these databases, there are other resources that provide information on the HLA-DPB1 gene and its variants. For example, the National Center for Biotechnology Information’s PubMed database contains scientific articles and references related to the HLA-DPB1 gene and its role in various diseases.

Genetic testing laboratories also maintain databases of genetic variants, including those in the HLA-DPB1 gene. These databases are used to interpret the results of genetic tests and provide additional information about the significance of specific variants.

Overall, gene and variant databases serve as valuable tools to increase our understanding of the genetic basis of diseases such as juvenile idiopathic arthritis and rheumatoid arthritis. They provide comprehensive information on genes, their variants, and their associations with various diseases, helping researchers and clinicians identify genetic changes that may trigger disease and aiding in the development of targeted treatments.

References

  • Bodmer, J.G., Marsh, S.G.E., Albert, E.D. et al. “Nomenclature for factors of the HLA system, 2010”.(2010) Tissue Antigens 75, 291-455.
  • PubMed ID 1438306 “Polymorphic genes of the DP region: recombination within the HLA-DP subregion, evolution of second domain of the DP polypeptide, and extent of polymorphism”.(1992) Immunogenetics 35, 351-356.
  • PubMed ID 8505526 “HLA dot plots: visualising the HLA haplotype structure of populations using HLA-B, -C, -DRB1 and -DQB1 allele frequencies”. (1993) Tissue Antigens 41, 47-59.
  • PubMed ID 28344920 “MHC class II haplotypes of susceptibility in Romanian patients with juvenile idiopathic arthritis (JIA)”. (2017) BMC Rheumatology 1:8.
  • PubMed ID 12378023 “Polymorphisms in HLA-DP and HLA-DQ are not independently associated with pemphigus vulgaris”. (2002) J Invest Dermatol 119, 570-575.