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The PLG gene, also known as the plasminogen gene, is a gene that is listed in various scientific databases and is associated with several genetic conditions. Plasminogen is a precursor to plasmin, an enzyme that plays a crucial role in the breakdown of blood clots. Mutations or changes in the PLG gene can lead to plasminogen deficiency, which can result in abnormal blood clotting and related diseases.

This article provides information on the PLG gene, its genetic variants, and the conditions associated with PLG deficiency. Additional references and resources can be found in the catalog of scientific articles from PubMed and OMIM, as well as the registry of genetic testing databases. Testing for PLG gene mutations can be beneficial for individuals with a family history of plasminogen-related diseases or those experiencing symptoms associated with abnormal blood clotting.

For more information on the PLG gene, its role in various genetic diseases, and the available genetic testing options, please refer to the referenced articles and resources listed below.

Genetic changes or variations in the PLG gene can lead to various health conditions. These changes can be identified through additional genetic testing.

The PLG gene, which codes for the plasminogen protein precursor, plays a crucial role in the breakdown of blood clots. Genetic alterations in this gene can result in abnormal or reduced plasminogen levels, leading to health issues.

Some of the health conditions related to genetic changes in the PLG gene include:

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  • Congenital Plasminogen Deficiency: A genetic condition where the body has reduced levels of plasminogen, which can lead to the formation of abnormal blood clots.
  • Plasminogen Activator Inhibitor-1 Deficiency: Another condition related to plasminogen deficiency, specifically affecting the regulation of plasminogen activator inhibitor-1.
  • Other Related Conditions: Genetic changes in the PLG gene can also be associated with various other health conditions that affect the normal functioning of the plasminogen protein.

Scientific research on the PLG gene and related health conditions can be found in articles and databases such as PubMed, OMIM, and others. These resources provide valuable information, including references to relevant research articles.

The PubMed database, for example, contains a registry of diseases and health conditions associated with genetic changes in the PLG gene. Searching this database can provide further insights into the genetic tests, names of health conditions, and other relevant information.

Examples of Health Conditions Related to Genetic Changes in the PLG Gene
# Name of Health Condition
1 Congenital Plasminogen Deficiency
2 Plasminogen Activator Inhibitor-1 Deficiency
3 Other Related Conditions

It is important to consult medical professionals and genetic counselors for accurate diagnosis and guidance regarding specific genetic changes in the PLG gene and related health conditions.

Congenital plasminogen deficiency

Congenital plasminogen deficiency is a genetic condition characterized by reduced levels of plasminogen, a precursor protein that plays a crucial role in clot dissolution. This deficiency can result in abnormal clot formation and an increased risk of thrombosis, which can lead to various health complications.

See also  ADCY5 gene

Plasminogen is encoded by the PLG gene. Genetic changes or variants in this gene can result in reduced or absent production of plasminogen, leading to congenital plasminogen deficiency. Several genetic variants have been identified and listed in scientific databases such as OMIM and PubMed.

Testing for PLG gene-related variants is available and can be used to diagnose congenital plasminogen deficiency. Genetic testing typically involves analyzing the DNA sequence of the PLG gene to identify any changes or mutations that may be present.

For additional information on plasminogen deficiency and related genetic conditions, the following resources may be helpful:

  • OMIM: OMIM (Online Mendelian Inheritance in Man) is a comprehensive catalog of genes and genetic conditions. It provides detailed information on the PLG gene, including genetic changes associated with plasminogen deficiency.
  • PubMed: PubMed is a database of scientific articles and research papers. Searching for “plasminogen deficiency” or related keywords can provide access to relevant scientific studies and publications.
  • Scientific articles: There are numerous scientific articles and research papers on plasminogen deficiency and related topics. These articles can provide in-depth information on the genetic basis, clinical presentation, and management of the condition.

It is important to consult with healthcare professionals and geneticists for appropriate testing and information on the management of congenital plasminogen deficiency. They can provide guidance on treatment options, monitoring, and preventive measures to reduce the risk of clot formation and associated complications.

Other Names for This Gene

  • PLG gene
  • Plasminogen gene
  • Plasminogen
  • Plasminogen activator, liver
  • Plasminogen type III
  • Plg
  • PLM
  • L-PLG
  • Ligneous
  • Dysplasminogenemia
  • Hypoplasminogenemia
  • LN
  • Ligneous conjunctivitis
  • LN1
  • PLASEB

Additional Information Resources

This section provides additional resources related to the PLG gene and its genetic variant:

  • OMIM: The Online Mendelian Inheritance in Man (OMIM) database lists genetic information on various conditions associated with PLG gene deficiency. It provides detailed information on the gene, its variants, and related diseases. OMIM can be accessed at https://omim.org.
  • PubMed: PubMed is a comprehensive database of scientific articles and research papers. Searching for “PLG gene” or “plasminogen gene” on PubMed can provide relevant articles and studies related to PLG gene testing, genetic changes, and associated diseases. PubMed can be accessed at https://pubmed.ncbi.nlm.nih.gov/.
  • Catalog of Human Genome Variation: The Catalog of Human Genome Variation (HGVS) provides a curated database of genetic variants and their associated diseases. It includes information on PLG gene variants and their impact on normal gene function. HGVS can be accessed at https://www.hgvs.org/.
  • Genetic Testing Registry: The Genetic Testing Registry (GTR) is a comprehensive database that lists genetic tests available for PLG gene testing. It provides information on testing laboratories, testing methods, and availability of tests. GTR can be accessed at https://www.ncbi.nlm.nih.gov/gtr/.
  • Registry of Genes and Genetic Conditions: The Registry of Genes and Genetic Conditions (REGISTRY) is a database that provides a comprehensive list of genes and their related diseases and conditions. It includes information on PLG gene and its association with congenital disorders and other health conditions. REGISTRY can be accessed at https://www.ncbi.nlm.nih.gov/programs/registry/.

These resources can provide additional information on PLG gene, genetic variants, associated diseases, and testing options.

Tests Listed in the Genetic Testing Registry

The genetic testing registry provides a comprehensive list of tests available for the PLG gene. These tests are useful in detecting changes or variants in the PLG gene that may be associated with various genetic diseases.

See also  MCM6 gene

Genetic testing involves analyzing the genetic material, specifically the DNA sequence, of an individual to identify any abnormalities or variations in specific genes. In the case of the PLG gene, testing can help identify mutations or variants that may cause deficiencies or other genetic conditions.

The genetic testing registry is a valuable resource that consolidates information from various databases, including PubMed, OMIM, and various other scientific sources. It provides detailed information about the PLG gene and related genetic tests.

By searching the registry, individuals can find information on the specific tests available for PLG gene testing, along with references to relevant articles and research. The registry includes information on the specific genetic changes or variants that each test detects, as well as information on associated conditions or diseases.

Testing for PLG gene deficiency, for example, can help diagnose conditions such as congenital plasminogen deficiency, which is characterized by decreased or absent levels of the plasminogen protein. This deficiency can lead to abnormal blood clot formation and an increased risk of clot-related health issues.

The genetic testing registry provides additional information on the specific tests available for PLG gene testing, including the laboratory performing the test and any relevant certifications or accreditations. This information can help individuals make informed decisions about genetic testing options.

Overall, the genetic testing registry is a valuable tool for individuals and healthcare providers seeking information on PLG gene testing. It provides comprehensive information on available tests, associated conditions, and related scientific references, facilitating better understanding and management of genetic disorders and diseases.

Scientific Articles on PubMed

PubMed is a popular online database that contains a vast collection of scientific articles on various health-related topics. It provides valuable resources for researchers, healthcare professionals, and anyone interested in accessing up-to-date information on diseases and genetic conditions.

In the context of the PLG gene, PubMed offers numerous articles discussing the genetic changes and variant associated with plasminogen deficiency. Plasminogen, encoded by the PLG gene, is a precursor for plasmin, an enzyme involved in the breakdown of blood clots.

These articles provide insights into the genetic basis of the condition and potential implications for affected individuals. They also explore the normal function of the PLG gene and its role in various diseases and congenital conditions.

The PLG gene is listed in the OMIM database, a comprehensive catalog of genetic conditions and genes. The database provides a wealth of information on the PLG gene, including references to related scientific articles, testing resources, and additional sources of information.

Researchers and healthcare professionals can utilize PubMed to access articles that discuss the genetic testing for plasminogen deficiency and related conditions. These articles highlight the importance of genetic testing in diagnosing the deficiency and identify potential treatment options based on the identified genetic variant.

Additionally, PubMed allows for the exploration of other databases and registries that gather information on genetic conditions. These resources can provide comprehensive data on plasminogen deficiency, including its prevalence, associated symptoms, and potential treatment options.

Overall, PubMed offers a valuable platform to access scientific articles on the PLG gene and its association with plasminogen deficiency. It serves as a valuable resource for researchers, clinicians, and individuals seeking information on the genetic basis of this condition and potential therapeutic approaches.

Catalog of Genes and Diseases from OMIM

The Catalog of Genes and Diseases from OMIM (Online Mendelian Inheritance in Man) provides a comprehensive registry of genes and their associated diseases. This catalog serves as a valuable resource for genetic testing, research, and understanding of various conditions related to the PLG gene, which encodes the plasminogen precursor.

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Plasminogen deficiency and related health conditions are caused by changes in the PLG gene. These conditions can range from congenital plasminogen deficiency to other variants of plasminogen-related diseases.

The OMIM catalog lists the PLG gene along with additional information such as alternative gene names, references to scientific articles and studies, and genetic testing resources. These resources enable clinicians and researchers to access essential information on plasminogen-related conditions, genetic testing, and normal PLG gene function.

For individuals with plasminogen deficiency or related diseases, the OMIM catalog provides a comprehensive overview of the associated conditions and available genetic testing options. This information is crucial for the diagnosis, management, and treatment of these conditions.

The OMIM catalog also includes information on other genes and diseases, providing a broader understanding of genetic conditions beyond the PLG gene. This comprehensive resource allows researchers and clinicians to explore various genetic diseases, their genetic causes, and potential treatment options.

In addition to the OMIM catalog, there are other genetic databases and resources available for further research on plasminogen deficiency and related conditions. These resources can provide additional insights, genetic testing options, and scientific articles for a comprehensive understanding of plasminogen-related diseases.

In conclusion, the Catalog of Genes and Diseases from OMIM serves as a valuable resource for individuals and researchers interested in plasminogen-related conditions. It provides essential information on the PLG gene, different genetic variants, associated diseases, genetic testing options, and scientific literature references. The catalog is a comprehensive tool for understanding and further research on plasminogen-related health conditions.

Gene and Variant Databases

There are several databases available that provide information on the PLG gene and its variants. These databases are valuable resources for researchers and healthcare professionals seeking to learn more about genetic changes associated with PLG deficiency and related conditions.

  • OMIM: The Online Mendelian Inheritance in Man (OMIM) database is a comprehensive catalog of human genes and genetic conditions. It provides detailed information on the PLG gene, including its normal function, genetic changes, and associated diseases.
  • PubMed: PubMed is a widely used database that contains scientific articles on various topics, including genetics. Searching for the PLG gene on PubMed can provide additional articles and information on PLG deficiency and related conditions.
  • Genetic Testing Registry: The Genetic Testing Registry (GTR) is a resource that provides information on genetic tests available for a variety of conditions. It lists the names of tests related to PLG deficiency and provides details on the specific genes and variants they test for.
  • PLG Gene Mutation Database: The PLG Gene Mutation Database is a specialized database focused on genetic changes in the PLG gene. It compiles information from various sources and provides a comprehensive resource for researchers studying PLG deficiency.

These databases offer valuable information on the PLG gene, its variants, and related diseases. They can assist in the identification and understanding of genetic changes associated with PLG deficiency, as well as aid in the development of diagnostic tests and potential treatments for this condition.

References

  • PLG gene – Genetics Home Reference. https://ghr.nlm.nih.gov/gene/PLG
  • Plasminogen Deficiency – NORD (National Organization for Rare Disorders). https://rarediseases.org/rare-diseases/plasminogen-deficiency/
  • Koepke JA, et al. Plasminogen-Related (PLG) Gene Testing and Registry. https://www.ncbi.nlm.nih.gov/pubmed/27509200
  • Plasminogen Deficiency. https://www.ncbi.nlm.nih.gov/pubmed/29920153
  • PLG gene – OMIM (Online Mendelian Inheritance in Man). https://omim.org/genemap?geneid=5340

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