Propylthiouracil

Propylthiouracil may cause severe liver damage in adults and children. Some people who took propylthiouracil needed liver transplants and some people died because of the liver damage. Because of this risk, propylthiouracil should only be given to people who cannot receive other treatments such as surgery, radioactive iodine, or a different medication called methimazole (Tapazole). Propylthiouracil may also be given to women during the first months (about 12 weeks) of pregnancy because methimazole may cause birth defects if it is used during this part of a pregnancy.

If you are taking propylthiouracil, call your doctor immediately if you develop any of the following symptoms: fever, loss of appetite, nausea, vomiting, tiredness, itching, dark urine, pale or light colored stools, yellowing of the skin or eyes, or pain in the upper right part of the stomach.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with propylthiouracil and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm).

🔔 Why is this medication prescribed?

Propylthiouracil is used to treat hyperthyroidism (a condition that occurs when the thyroid gland produces too much thyroid hormone, speeding the body’s metabolism, and causing certain symptoms) in adults and children 6 years of age or older. Propylthiouracil is in a class of medications called antithyroid agents. It works by stopping the thyroid gland from making thyroid hormone.

🔔 How should this medicine be used?

Propylthiouracil comes as a tablet to take by mouth. It is usually taken three times a day, once every 8 hours. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take propylthiouracil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor may decrease your dose of propylthiouracil once your condition is controlled.

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Continue to take propylthiouracil even if you feel well. Do not stop taking propylthiouracil without talking to your doctor.

See also  Ruxolitinib

🔔 Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

🔔 What special precautions should I follow?

Before taking propylthiouracil,

  • tell your doctor and pharmacist if you are allergic to propylthiouracil, any other medications, or any of the ingredients in propylthiouracil tablets. Ask your doctor or pharmacist or check the Medication Guide for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants (‘blood thinners’) such as warfarin (Coumadin), beta blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard), and propranolol (Inderal); digoxin (Digitek, Lanoxin), and theophylline (Theo-24, Theochron, Theolair). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with propylthiouracil, so be sure to tell your doctor about all the other medications you are taking, even if they do not appear on this list.
  • tell your doctor if you have or have ever had leukopenia (decreased white blood cells) , thrombocytopenia (decreased platelets), or aplastic anemia (condition in which the body does not make enough new blood cells), or other conditions that cause low numbers of red blood cells, white blood cells, or platelets; or liver disease.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking propylthiouracil, call your doctor.Your doctor may tell you to take propylthiouracil during the first months of your pregnancy only and then may switch you to methimazole for the rest of your pregnancy. Propylthiouracil may cause severe liver problems in pregnant women and may harm the fetus.
  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking propylthiouracil.

🔔 What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.