Which Eyedrops Help Eye Allergies

Examples of over-the-counter decongestant eyedrops are:

Allergy eye drops: Which ones will bring you relief?

If you suffer from allergies, you’ve probably tried allergy eye drops or are thinking about giving them a try to relieve your ocular allergy symptoms.

This article will help you understand more about allergy eye drops and whether they might be helpful to give you relief from your itchy, watery, swollen or red eyes.

What causes eye allergies?

An allergic reaction occurs when a person’s immune system reacts to an allergen (irritant) in the environment, either indoors or outdoors. An allergen is any substance that causes allergy symptoms in sensitive individuals.

When confronted by an allergen, the immune system perceives it as an invader and goes into overdrive to produce histamines) to fight it. This is known as an allergic reaction.

There are two basic categories of allergic reactions. One is to seasonal allergens related to changes in nature — such as mold spores and pollens from trees, grass and weeds. People with seasonal allergies usually notice that their symptoms worsen when they go outside on days when pollen counts are high.

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The other type of allergic reaction is to year-round allergens that are typically found indoors, like dust mites, pet dander, mold and mildew. Symptoms for people with year-round allergies usually become more noticeable when they do things that set the allergens in motion, like brushing a pet or cleaning house.

The good news is that there are several effective allergy eye drops that can help reduce allergic symptoms.

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How allergy eye drops can help

There are many allergy eye drops available — including non-prescription, over-the-counter (OTC) eye drops and medicated drops that require a prescription from your eye doctor.

The best allergy eye drops for you depends on several factors, including the cause of your allergy and the severity of your symptoms.

Some allergy eye drops are formulated for short-term use for acute symptoms, while others are designed for long-term use to prevent symptoms from occurring or reduce your sensitivity to allergens.

The best allergy eye drops are those that work two different ways, says Tammy Than, OD, FAAO, and spokesperson for the American Academy of Optometry.

“These drugs work as an antihistamine — which helps with the itching, swelling and redness — and are also mast cell stabilizers which help prevent further release of chemicals that cause the allergies,” she says. “So these drops help with current symptoms and prevent future symptoms.”

Types of allergy eye drops

Antihistamine eye drops

Antihistamine eye drops are usually the first suggested treatment when symptoms become too strong to handle without medication.

Antihistamine eye drops block histamines in the body and quickly reduce symptoms like itchy, watery eyes. But the relief they provide may last only a few hours; so multiple doses throughout the day may be required.

Prescription antihistamine eye drops include Optivar, Emadine and Livostin.

Anti-inflammatory allergy eye drops

Anti-inflammatory allergy eye drops include nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids. NSAID eye drops affect nerve endings, reducing itchiness within an hour after use.

Anti-inflammatory allergy eye drops may cause burning or stinging when first administered.

Acular and Acuvail are prescription allergy eye drops used for treating itchy eyes.

Corticosteroid eye drops

Corticosteroid eye drops eye drops are prescribed for treating long-term or severe eye allergic reactions.

Corticosteroid eye drops are usually recommended for short-term use because possible side effects include cataracts, glaucoma and high eye pressure (ocular hypertension).

Alrex and Lotemax are two prescription steroid eye drops used to treat allergic conjunctivitis.

Mast cell stabilizers

Mast cell stabilizers are another type of allergy eye drops. Mast cell stabilizers work by preventing the release of histamine and other chemicals produced by the body during an allergic reaction.

Mast cell stabilizers may be used for months without side effects, and they may allow contact lens users to continue wearing their contact lenses comfortably throughout allergy season.

Brands of OTC mast cell stabilizer allergy eye drops include Claritin Eye and Refresh Eye Itch Relief. Mast cell stabilizer allergy eye drops available by prescription only include Crolom, Alomide, Alocril and Alamast.

Multiple-action allergy eye drops

Multiple-action allergy eye drops, also known as dual-action eye drops, combine more than one type of medication. The antihistamine/decongestant combo treats itchy, watery and red eyes and are marketed as Vasocon-A, Opcon-A and Naphcon-A.

Another version of multiple-action allergy eye drops combines an antihistamine and mast cell stabilizer. OTC products in this category contain ketotifen and include Zaditor and Alaway. These multiple-action allergy eye drops can be used twice a day.

Once-a-day prescription multi-action drops include Lastacaft, Pataday and Pazeo. They are safe to use long term during allergy season or for year-round allergies.

Decongestant allergy eye drops

Finally, decongestant allergy eye drops reduce the red, bloodshot appearance of the eyes affected by allergic conjunctivitis. These products work by reducing the size of dilated blood vessels under the conjunctiva.

Decongestant allergy eye drops should be used for only a short period of time due to the risk of “rebound hyperemia” that makes the redness return after the drops are used frequently and then are discontinued.

OTC decongestant allergy eye drops include Clear Eyes, Refresh and Visine.

Follow the directions on the label

Whichever allergy eye drops you choose, always follow the instructions for recommended use on the label to minimize the risk of irritation and other side effects.

Limit your use of OTC and prescription allergy eye drops to what the label specifies (usually 2-3 times per day). If the drops cause increased redness or irritation, consult an eye doctor immediately.

Doctor recommended allergy eye drops

With so many allergy eye drops available, it can be nearly impossible to choose the best brand and formulation for your needs.

For the greatest relief from eye allergy symptoms, see an eye doctor near you for a careful evaluation and a professional recommendation of the best allergy eye drops for you.

Page published on Wednesday, August 14, 2019

Which Eyedrops Help Eye Allergies?

Allergy eyedrops are liquid medicines used to treat symptoms of eye allergies. Eye allergy symptoms include:

• A burning feeling in your eye
• Feeling like something is in the eye
• Itchy eyes
• Red (bloodshot) eyes
• Swollen eyelid
• Tearing

An eye allergy can be triggered by the same things that cause hay fever, such as:

Certain medications or contact lenses can also be triggers.

Types of Allergy Eyedrops

Your doctor may first suggest you take these steps:

• Use artificial tears.
• Place a cold cloth on the eyes.
• Avoid your allergy triggers.

Which type of allergy eyedrop you use depends on:

• The cause of your allergy
• Your symptoms
• How much the symptoms affect your daily activities

There are many types of allergy eyedrops. Not all treat all allergy symptoms. For example, one that relieves red eyes may not stop the itching.

Some are sold over the counter. For others you need a prescription from a doctor. Some relieve symptoms quickly. Others provide long-term relief.

The types of allergy eyedrops include:

• Antihistamine
• Anti-inflammatory
• Decongestant
• Mast cell stabilizers
• Multiple action

Antihistamine Allergy Eyedrops

Doctors usually recommend these as the first treatment for eye allergies if you can’t get enough relief without drugs.

If you have itchy, watery eyes, antihistamine eyedrops may make you feel better. These medicines block histamine in the body. Histamine is a chemical that your immune system makes when you come in contact with an allergy trigger. It causes many of your allergy symptoms.

Antihistamine eyedrops can quickly ease your symptoms. But relief may only last for a few hours. It can also cause your eyes to be more dry. You may need to use the drops several times a day.

Antihistamine eyedrops include:

• Azelastine hydrochloride (Optivar)
• Emedastine difumarate (Emadine)
• Levocabastine (Livostin)
• Alcaftadine (Lastacaft)

Anti-inflammatory Allergy Eyedrops

These eyedrops fall into two groups:

• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Corticosteroids

NSAID eyedrops affect certain nerve endings. They change the way your body makes you feel itchy.

Ketorolac (Acular, Acuvail) is the only NSAID approved for the treatment of itchy eyes. Itching usually starts to go away about 1 hour after using the eyedrops. These eyedrops often cause stinging or burning when first placed in the eyes.

Corticosteroid eyedrops are used to treat severe, long-term eye allergy symptoms. Prescription steroid eyedrops include loteprednol (Alrex, Lotemax).

Doctors generally don’t recommend corticosteroid drops for long-term use, unless your case is really severe, due to possible side effects such as increased eye pressure and cataracts.

When you use corticosteroid eyedrops, you should have regular checkups with an eye specialist to check on your eye health. These eyedrops can make you more likely to get:

• Cataracts
• Eye infection
• Glaucoma
• Increased pressure in the eye

Decongestant Allergy Eyedrops

These eyedrops can quickly brighten the whites of your eyes and reduce eye redness for a short time. They narrow blood vessels in the eye area. This relieves the red, bloodshot appearance of the eyes but carries longterm risk of “rebound redness,” which is making your eyes permanently bloodshot. As a result, they are not recommended for longterm use.

You can get these eyedrops without a prescription. But doctors don’t recommend them to treat eye allergies.

Examples of over-the-counter decongestant eyedrops are:

• Naphazoline HCL (Clear Eyes)
• Phenylephrine HCL (Refresh)
• Oxymetazoline HCL (Visine)
• Tetrahydrozoline HCL

There are some risks. If you use them for too long, it can make your eye problem worse, with “rebound redness.” Redness and eye swelling can continue even when you stop using the drops.

If you have glaucoma you should never use decongestant eyedrops.

Mast Cell Stabilizer Allergy Eyedrops

These are among the newest types of eyedrops. They help prevent the release of histamine and other chemicals made by your body during an allergic reaction.

Mast cell stabilizers are made to prevent your symptoms.

You may be able to use these drops for many months without any side effects. If you wear contacts, mast cell stabilizers may let you wear them longer.

Over-the-counter mast cell stabilizer drops include:

• Ketotifen fumarate (Claritin Eye, Refresh Eye Itch Relief)

Prescription mast cell stabilizer eyedrops include:

• Cromolyn (Crolom)
• Lodoxamide (Alomide)
• Nedocromil sodium (Alocril)
• Pemirolast potassium (Alamast)

Multiple-Action Allergy Eyedrops

Some eyedrops contain more than one type of medicine. These are called dual-action or multiple-action eyedrops.

Antihistamine/decongestant combination eyedrops reduce eye itching, watery eyes, and redness. Examples include:

• Antazoline phosphate/naphazoline HCL (Vasocon-A)
• Pheniramine maleate/naphazoline HCL (Opcon-A and Naphcon-A)

Antihistamine/mast cell stabilizer combination eyedrops treat and prevent:

These newer eyedrops are especially helpful for people with a condition called allergic conjunctivitis. Examples include:

• Epinastine (Elestat)
• Ketotifen (Alaway, Zaditor)
• Olopatadine hydrochloride (Pataday, Patanol)
• Cetirizine (Zerviate)

Side Effects and Risks

As with any medicine, you should always follow the recommended instructions on the label. You shouldn’t use over-the-counter eyedrops for more than 2 to 3 days. If you use them for longer than that, it can make matters worse.

If you have an eye infection or glaucoma, you shouldn’t use eyedrops. Talk to your doctor about other options.

Some eyedrops may sting or burn when you place them in your eyes. It can help to store them in your fridge.

You can’t use many eyedrops while you wear contact lenses. Your doctor may tell you to remove your lenses before you use the drops and wait at least 10 minutes before you put them back in. Or you may not be able to wear contact lenses at all during treatment with eyedrops.

You’ll need to use most allergy eyedrops several times a day.

Show Sources

Healthy Women: “Ocular Allergies.”

American College of Allergy, Asthma, and Immunology: “Eye Allergy Treatment.”

University of Michigan Kellogg Eye Center: “Allergies of the Eye.”

Kliegman, R.M., Behrman, R.E., Jenson, H.B., Stanton, B.F., editors, Nelson Textbook of Pediatrics,19th edition, Saunders Elsevier, 2011.

Bielory, L. Immunology and Allergy Clinics of North America, February 2008.